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Saved by @ThomassRichards

It is #BellLetsTalk ...so let’s talk. Have you ever responded to the question “how are you doing?” with a “fine” or “good” even though you really weren’t fine or good?! I know I certainly have.

 While every time you are asked it may not be a great time to delve into what is going on I challenge you and myself to be courageous enough to answer how you are really doing. Especially when talking with those people that you have around you that are your support system.
As a nurse I find that I am constantly observing and assessing my patients and residents. How are they doing (both physically and mentally)? Trying my hardest to notice the big and small changes that could mean they aren’t doing as well or hopefully doing better.
I challenge you healthcare workers to turn that observation and assessment on yourself and coworkers. Did you notice the subtle and sometimes glaringly obvious signs of chronic stress and burnout? I certainly didn’t.
So now it’s time to talk....talk to your family, talk to your friends, talk to your coworkers, talk to your children. Check in with them, don’t settle for “fine” “good”. Make a safe space for people to open up to you and for you to them.
In our house we try to use the three word system. What might that be you ask? Well as some of you may know getting a child to say anything about their day other than fine or good can be hard. And such was the start of the three word system.
Describe your day using three separate descriptive words. “Boring” “sad” “frustrating” “fun” you get the point. This can open conversation up to ...what happened to make it frustrating, sad, fun, etc. It really makes you reflect on “how am I doing” “how was my day”.
Condensing these big thoughts down to three words can really make you think....and that’s the point! Do we do this everyday, nope, we are busy and forgetful too. But it helps us stay in touch with how each other is doing, maybe it can help you too.
And if you don’t have a support system or can’t talk to them please talk with someone. Many work places have access to Employee and Family Assistance Program. Wellness Together Canada has 24/7 FREE resources and chat. Kids Help Phone 24/7 FREE. Crisis Textline 24/7 FREE help.
So let’s get talking because as a friend and coworker always reminds me “when you know better than we must do better”. So let’s do better with our mental health and care for those around us everyday and especially today on #BellLetsTalkDay.
P.S. How am I doing today you ask? “Optimistic” “Exhausted” “Content” How are you today?

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Jason_Q
Jason_Q
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Ok. Here we are. Again. Doom@and gloom. Ya know.....POTUS never says anything without there being something coded within it. Including his short speech last night.

Anyone catch the color of the tie?
It was a baby blue tie with hints of pink. You know. Nursery colors

Because what was it all about? The CHILDREN.

So first off. When we look at numbers of missing children in the 90’s during the Clinton Child Catching and Cooking Machine and THEN compare that with the #’s of that pesky “V” from Chiiiina” ...

There were over 900k kids missing EACH YEAR during their Reign of terror... was there ANY alert or warning about an increase yearly of child snatching?

Nope.

So when you create something in a lab and blame it on “bat soup” in a market... with a survival rate of 99.4%..

Any alarm or warning?

Oh just a “Pan”demic level 6 ( it’s so amusing that these sick pricks use the half man / half goat god Pan along with demic with a level of 6 to stress the pure evil in this)

I to o is 6 spaces
C to n is 11 spaces.

Demic to demon is 17 letter shifts

Wouldn’t it just surprise you that the finishing of #17 left us with 17 spaces left...🤔💫💫
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jeevan patwa
jeevan patwa
@jeevanpatwa
#SuvenLife – Niche R&D play..very high risk and very high reward…key is right allocation…

Jazz Pharma was quoting around $0.5 in 2009, today its $150 and Mcap of $8.5 Bn on Nasdaq..almost 300x in 11 years. 80% of its total sales ($2.1 Bn) come from single drug Xyrem.

Axovant Lifescience, bought Alzheimer molecule from GSK, repackaged it and done phase-3 trials. Before starting the trials, the valuation was $2 Bn, just before announcing the data, it rose to $3 Bn. One of the leading broker put the target of $12 Bn if the trials succeeded..

but it failed in phase-3 trials. Current Mcap is $120 Mn…

This is R&D for New Chemical Entity (NCE)…very high risk and very high reward…

Brain-related illnesses, also known as CNS diseases, afflict more than 2 billion people worldwide. Diseases of the brain and mind range

from Alzheimer’s, dementia, epilepsy, migraine, multiple sclerosis, neuro infections, Parkinson’s, psychosis, schizophrenia and stroke to brain injuries and various mental disorders. The global market or CNS therapeutics is projected to reach $137.7 billion by 2025.

#SuvenLife has 1 lead molecule SUVN-G3031 in phase-2 trials which is similar to Xyrem but superior features, 3 molecules completed phase-1 trials and starting phase-2 trials and 11 molecules in pre-clinical trials. All are related to CNS which is growing and uncluttered market
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TXgrlWatching💻⚔🛡...
@VeritasTXgem
Thread Pt 3 Who is Prometheus?

1. In Greek mythology, Prometheus, is a Titan of fire. Prometheus is a culture hero & trickster figure who is credited with the creation of humanity from clay, and who defies the gods by stealing fire and giving it to humanity as civilization.
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Dr Raul Pacheco-Vega
Dr Raul Pacheco-Vega
@raulpacheco
THREAD: On the full-fledged process of responding to a Revise-And-Resubmit (R&R).

I have written pieces of the process, but I hadn't actually written a thread or a blog post showcasing how all my blog posts fit with one another. I teach this process when I give workshops.

So here's what I do (now), and let me share a lesson from my past lives:

DO NOT SIT ON R&Rs.

I know, they're painful and scary and sometimes we don't know if our paper will get rejected in the end.

But remember, an R&R means an OPPORTUNITY to get your paper published.

Sitting on R&Rs, leaving them for later, and not prioritizing them has gotten me fewer publications. I know this for a fact. I am not ashamed of admitting that I have sometimes felt that I will not be capable of responding to multiple (often conflicting) comments.

HOWEVER...

Sustained, frequent advice from professors who are senior to me (though I am senior myself now too) is always the same and on-point:

The goal is the R&R.

You're not getting a desk rejection.

You are getting your work read, reviewed carefully, thought about, responded to.

What do I do now (and have been doing for the past few years, with success)

When I get the R&R (the "decision letter"), I make sure to calm down, because I am always afraid I'm going to get nasty comments. These have been (luckily) very rarely present in my latest submissions.
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To the person who thinks that they might be autistic. - a thread. /1

I imagine you have gone your entire life wondering why you are different, why you can't seem to understand things the way that others can and why everything just seems so hard. I'm proud of you for getting this far. /2

Part of you might be thinking:
"But if I was autistic, surely it would've been noticed when I was a kid? So maybe I'm making this up."
So many autistic people aren't diagnosed until they are adults, if diagnosed at all. You would not be the first and you won't be the last. /3

"My family and friends don't think that I could be autistic."
People's understandings of autism tend to be based off of the media, which doesn't show every possible presentation of autism, or based off of someone they know, and all autistic people present differently. /4

People's perceptions of autism can also be based off stereotypes, for example, "autistic people can't make eye contact, so you can't be autistic." While this is true for some, it isn't for all, so you can begin to see how one presentation of autism can't possibly fit everyone. /5
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Joey Tawadrous 🇮🇪...
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1) Core attributes of a promising founder worth following:
- Progress/trajectory over time
- How well they lead a team &
- Make the vision happen
- Most impressed when someone is way ahead of where you thought they would be when you check up/see them a few months later.

2) Indie Makers have such a benefit of being small, fast, nimble workers in comparison to big companies.

We can easily pivot and vastly change a project of ours. We can change as we learn more about our users.

Big companies can take months/years for even the smallest of pivots.

3) Before you find a product market you can pivot your project as many times as necessary until you find something that works.

Then you only have one thing to do: scale, scale, scale.

4) Be obsessed with the little details.
- listen to every single person who uses your product
- reply to every single person who emails you about your product
- ask them what they like and do not like
- iterate your product, make changes, pivot if necessary

5) Paul Graham's (@paulg) name came up with a feeling of great admiration! Naturally! It was Paul who said:

In the early stages of a company just;
- write code
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Nothing else.
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Patrick McKenzie
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@patio11
Some people really benefit from hearing advice that everyone knows, for the same reason we keep schools open despite every subject in them having been taught before.

In that spirit, here's some quick Things Many People Find Too Obvious To Have Told You Already.

Your idea is not valuable, at all. All value is in the execution. You think you are an exception; you are not. You should not insist on an NDA to talk about it; nobody serious will engage in contract review over an idea, and this will mark you as clueless.

Technologists tend to severely underestimate the difficulty and expense of creating software, especially at companies which do not have fully staffed industry leading engineering teams ("because software is so easy there, amirite guys?")

Charge more. Charge more still. Go on.

The press is a lossy and biased compression of events in the actual world, and is singularly consumed with its own rituals, status games, and incentives. The news necessarily fails to capture almost everything which happened yesterday. What it says is important usually isn't.

Companies find it incredibly hard to reliably staff positions with hard-working generalists who operate autonomously and have high risk tolerances. This is not the modal employee, including at places which are justifiably proud of the skill/diligence/etc of their employees.
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Patrick McKenzie
Patrick McKenzie
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Most software founders, particularly in B2B, need to get radically better at sales. @Steli , who is the best person for explaining the scrappy stages in the beginning and then building out a team with scripts and processes, wrote a guide to:

For technical founders it is irrationally, obscenely hard to reverse years of programming (ba dum bum) that sales is a value-destroying activity. Sales is CLEARLY a value-creating activity, contingent on you have a value-creating product.

The world will not drop what they are doing to adopt your work. This is particularly true in B2B, where simply building a better mousetrap won't overcome the activation energy required to get people with additional non-mice problems to prioritize changing mousetraps today.

This is very non-obvious for founders because founders are not often people who *want* to be sold to. We often come from a background where trying out tools is a bit of a fun hobby. We like looking at all the options, making charts, and ripping out partially complete tests.

"This week I unsuccessfully trialed four software options for automating that thing that has been killing us. Our actual production process remains the same as last week. Don't worry; this was a great use of time." is not a thing you want to write in a progress report to manager.
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Professor
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Some ofthe biggest breakouts occur after Volatility Contraction, the analogy is that more a spring is pressed, higher it jumps whenever it gets released.

There is a VCP Scanner on chartink (Not mine). This may also be used to find potential Breakouts.
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Jaya_Upadhyaya
Jaya_Upadhyaya
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SRI LALITHAMBIGAI, THIRUMEYACHUR (TN)
#bharatmandir #navratri2021

Kshetram where Shiva is worshipped as Meghanatha and his consort is Lalithambigai seen in Abhay mudra.
Once, a demon Pandasura was harassing the Devas who went to Devi Parashakti for protection. 
@GunduHuDuGa


Devi rose from a Yaga Gunda, mounted on the Sri Chakra Rath with the name Lalithambika, waged a war against Pandasura and destroyed him.  When her fury did not subside, Shiva asked her to go to Earth, assume the name Manonmani, perform penance and shed her fury.


Shiva blessed Devi to be Shanta nayagi. There is a sculpture here depicting Shiva pacifying Devi. If you observe closely, you can see that from your left hand side there will be a smile on Her face and if you see from your right hand side you can see anger in Her face.


Hayagriva taught the greatness of Lalitha Sahasranama to Rishi Agasthya. Pleased with his devotion, Ma Lalithambikai appeared before Agastya. He is believed to have then sung Lalita Navaratnamala in praise of Devi. He has also composed a hymn named Rahasyanamasahasram.
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