I've worked on a mAb and i will happily admit i didn't get the details! 1/
@PaoloWalnuts I looked into this as I was very surprised and thought it could be quite dangerous to go against the trial design.
I learnt a lot while i was doing it! There are a lot of misunderstandings and quite a few counterintuitive bits as well.
Thread...
I've worked on a mAb and i will happily admit i didn't get the details! 1/
I know how limited pfizer are in what they can claim. If they don't have data to prove something they can't claim it, even if it *really* is obvious. They have data on 21 days so they either stay quiet or they say the data support 21dy interval. 5/
So, why choose 21 days? 7/
21 days should long enough to work but quick enough to get data 9/
I'll try to hunt out the threads i came across. 10/
I also think it's been poorly communicated though. I understand why - in many ways JVCI, SAGE, MHRA et al have a lot to worry about right now! 12/
Clearly, in this case, giving everybody 1 dose will provide much more protecting and save very many lives.
*I'm coming on to this... 14/
15/
The numbers are skewed by all the pts who were infected before they were given the vx, or in the 7-14 days after it was administered. The fact that those folks get covid doesn't tell us how effective the vx is (just how long it takes to start working). So? 16/
We don't need to worry about the vaccine being effective after 1 dose. It is, stunningly so. 17/
https://t.co/5nw32LPiEk
What it suggests to me is that the projections for January and February must be properly frightening.
— Chris McQuillan (@ChrisMcQuilla13) January 1, 2021
https://t.co/WkD6pFZVbz
@Sandyddouglas
This issue is, appropriately, contentious. As a vaccinologist - & citizen & relative of people in at-risk groups - I fully support the UK decision to increase dose intervals of both our Ox/AZ product and the Pfizer product. I'd happily receive either with a >8w gap. Here's why \U0001f9f5 https://t.co/PZaxgGJUj4
— Sandy Douglas (@sandyddouglas) January 1, 2021
https://t.co/U3OEnGOrpw
Like me, \u2066@petermbenglish\u2069 changed his mind about the one v two vaccine dose controversy. He blogs why here. https://t.co/W8I5cm7LAk
— Trisha Greenhalgh \U0001f637 #RejoinEU (@trishgreenhalgh) January 2, 2021
More from Design
A person who adamantly argues for why you are powerless and takes offense at your self-determination could not be more clear about what role they prefer you in.
— Salom\xe9 Sibonex (@SalomeSibonex) December 30, 2020
Around 2012, while on summer break from what I felt was a lackluster school year, I was kind of at a breaking point. A prominent designer was peddling this self-help program, a $6000 weeklong workshop that centered around dinner with him and his influential friends.
His response to a fan who was deeply inspired by him and wanted to be a better designer, who asked "what if I can't afford the $6000?" was "You simply don't *want* to afford it." It's not a priority for you. I remember seeing it on Facebook and getting up from my chair.
It was gross, and it felt like the latest incident in what seemed like a long generational road of manipulating impressionable young people into thinking that the only thing stopping them from having the lives of these visible figures was passion
It felt wrong. Absolutely wrong. I thought about my best friend from high school. Someone just as—if not more—talented than me in art. Both of us dreamed of going to the same art school. Only one of us did. His familial socioeconomics as his undocumented status made it impossible
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🗓 Release date: October 30, 2018
📝 New Emojis: 158
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To me, the most important aspect of the 2018 midterms wasn't even about partisan control, but about democracy and voting rights. That's the real battle.
2/The good news: It's now an issue that everyone's talking about, and that everyone cares about.
3/More good news: Florida's proposition to give felons voting rights won. But it didn't just win - it won with substantial support from Republican voters.
That suggests there is still SOME grassroots support for democracy that transcends
4/Yet more good news: Michigan made it easier to vote. Again, by plebiscite, showing broad support for voting rights as an
5/OK, now the bad news.
We seem to have accepted electoral dysfunction in Florida as a permanent thing. The 2000 election has never really
Bad ballot design led to a lot of undervotes for Bill Nelson in Broward Co., possibly even enough to cost him his Senate seat. They do appear to be real undervotes, though, instead of tabulation errors. He doesn't really seem to have a path to victory. https://t.co/utUhY2KTaR
— Nate Silver (@NateSilver538) November 16, 2018
Beautifully read: why bookselfies are all over Instagram https://t.co/pBQA3JY0xm
— Guardian Books (@GuardianBooks) October 30, 2018
THEY DO READ THEM, YOU JUDGY, RACOON-PICKED TRASH BIN
If you come for Bookstagram, i will fight you.
In appreciation, here are some of my favourite bookstagrams of my books: (photos by lit_nerd37, mybookacademy, bookswrotemystory, and scorpio_books)