PROBIOTICS & VIT D: "The vitamin D receptor is highly expressed in the gastrointestinal tract where it transacts gene expression..These results support the underlying hypothesis that the human gut microbiome and vitamin D metabolism are integrally related"
https://t.co/15rVFa1fkk

"Men with higher levels of 1,25(OH)2D and higher activation ratios, but not 25(OH)D itself, are more likely to possess butyrate producing bacteria that are associated with better gut microbial health."
"Several studies suggest that gut microbiota alter intestinal vitamin D metabolism (VDM), and probiotic supplements can affect circulating vitamin D levels."
"Because the serum 25(OH)D correlates with overall vitamin D storage, it is the preferred clinical measure to assess vitamin D sufficiency."
"Clinically, serum 25(OH)D levels ≥20 ng/ml are considered adequate while 25(OH)D levels <20 ng/ml are defined as vitamin D deficiency."
"However, it is the active form of vitamin D, 1,25(OH)2D, that interacts specifically with the vitamin D receptor (VDR) and transacts gene expression."
"Those men with the highest compared to lowest 1,25(OH)2D and activation ratios are more likely to possess butyrate-producing bacteria that are associated with favorable gut microbial health."
"25(OH)D levels vary with site and sun exposure, but 1,25(OH)2D levels do not follow this association."
"the serum 1,25(OH)2D was the factor that explained the highest proportion of the variance in α-diversity (e.g., bacterial species diversity within an individual) at just over 5%"
"Greater α-diversity [gut bacterial species diversity] is associated with higher 1,25(OH)2D levels and larger vitamin D activation and catabolism ratios."
"Overall, apart from known correlates such as race and geographic locations, measures of vitamin D metabolic flux were remarkably associated with microbial β-diversity"
"We report robust correlations between the vitamin D metabolites, 1,25(OH)2D and 24,25(OH)2D, and the gut microbiome in 567 older men representing six geographic sites across the United States"
"Those men with higher levels of 1,25(OH)2D had greater α-diversity, even after adjusting for previously characterized determinants of microbial diversity including age, geographical origin, race, PPI, and antibiotic use."
"Serum 25(OH)D is the preferred clinical measure because it is representative of overall body stores of vit D; however, our results suggest it is the regulation of VDM, reflected by active hormone & metabolic ratios rather than body stores that have the most health implications."
"The positive association between diversity metrics and vitamin D activation and catabolism ratios suggests that physiologically normal vitamin D flux is more likely to occur in individuals with healthy microbiomes."
"In summary, we provide strong evidence of important interactions between host vitamin D signaling and the health of the gut microbiome in older men."

More from Robin Monotti FRSA ⭐

The evidence based science shows that medical face masks for the healthy do not alter rates of community transmission of SARSCoV2 while they contribute to the plastic pollution of planet. Cloth & masks of other materials increase rates of infection through nebulization spread.

"Speaking through some masks dispersed largest droplets into a multitude of smaller droplets..smaller particles are airborne longer than large droplets (larger droplets sink faster), a mask might be counterproductive."
https://t.co/jBQlWRxcEL


Influenza like illness rates 3 times higher with cloth masks when compared to control group:
https://t.co/djT0mfutv9
Prof. Carl Heneghan, Oxford University: "The high quality trial evidence for cloth masks suggest they increase your rate of reinfection."


Please note, droplets smaller than 120 microns can't be measured. SARSCoV2 is 0.14 microns. This means that the nebulization effect of medical masks could not be measured, not that it does not happen. ⬇️


The really small aerosols <1 μm [the ones that pass through ALL surgical masks] can penetrate all the way to the alveoli - the basic units for gas exchange

More from Category c19

Let's talk about MASKS!


Thread 1:


Masks increase mortality because breathing through them nebulizes aerosols into smaller ones which bypass mucosal immunity & reach all the way into the alveoli, leading to acute respiratory distress syndrome (ARDS).


"Aerosols..within the most breathable size range between 0.5 & 5 μm, can carry SARS-CoV-2 deep to the terminal alveoli..if this transmission pathway does exist, it would bypass the mucociliary clearance & incubation period of the virus in the upper

The filtration material itself of N95's average pore size ~0.3−0.5 μm does not block finer aerosol laden with virions penetration, not to mention surgical masks.
All you need to know about COVID19
FACTS NOT FEAR

Covid 19 is a disease caused by the SARS-CoV-2 virus. SARS-CoV-2 is one of 7 coronaviruses known to man. 1/n

The pandemic is real. Excess deaths were observed in many countries. Not all countries were affected in the same way due to pre-existing immunity, the health status of the population and demographics (the proportion of elderly in the population) 2/n
https://t.co/65elPq3gp5


COVID 19 presents a high risk for the very few and negligible risk for the many.

The infection fatality rate in different age groups:
<19 y, IFR= 0.003%
20-49 y: IFR= 0.02%
50-69 y: 0.5%
>70y, IFR=

Not everybody is susceptible to the virus. If reinfected, pre-existing immunity from related viruses gives protection from developing the disease or from developing serious symptoms.
4/n

“The evidence that a subset of people has a cross-reactive T cell repertoire through exposure to related coronaviruses is

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1/ Here’s a list of conversational frameworks I’ve picked up that have been helpful.

Please add your own.

2/ The Magic Question: "What would need to be true for you


3/ On evaluating where someone’s head is at regarding a topic they are being wishy-washy about or delaying.

“Gun to the head—what would you decide now?”

“Fast forward 6 months after your sabbatical--how would you decide: what criteria is most important to you?”

4/ Other Q’s re: decisions:

“Putting aside a list of pros/cons, what’s the *one* reason you’re doing this?” “Why is that the most important reason?”

“What’s end-game here?”

“What does success look like in a world where you pick that path?”

5/ When listening, after empathizing, and wanting to help them make their own decisions without imposing your world view:

“What would the best version of yourself do”?