BC CATEGORY C19

Robin Monotti FRSA ⭐
@robinmonotti 4 years, 1 month ago 667 views

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"Men with higher levels of 1,25(OH)2D and higher activation ratios, but not 25(OH)D itself, are more likely to possess butyrate producing bacteria that are associated with better gut microbial health."

"Several studies suggest that gut microbiota alter intestinal vitamin D metabolism (VDM), and probiotic supplements can affect circulating vitamin D levels."

"Because the serum 25(OH)D correlates with overall vitamin D storage, it is the preferred clinical measure to assess vitamin D sufficiency."

"Clinically, serum 25(OH)D levels ≥20 ng/ml are considered adequate while 25(OH)D levels <20 ng/ml are defined as vitamin D deficiency."

"However, it is the active form of vitamin D, 1,25(OH)2D, that interacts specifically with the vitamin D receptor (VDR) and transacts gene expression."

"Those men with the highest compared to lowest 1,25(OH)2D and activation ratios are more likely to possess butyrate-producing bacteria that are associated with favorable gut microbial health."

"25(OH)D levels vary with site and sun exposure, but 1,25(OH)2D levels do not follow this association."

"the serum 1,25(OH)2D was the factor that explained the highest proportion of the variance in α-diversity (e.g., bacterial species diversity within an individual) at just over 5%"

"Greater α-diversity [gut bacterial species diversity] is associated with higher 1,25(OH)2D levels and larger vitamin D activation and catabolism ratios."

"Overall, apart from known correlates such as race and geographic locations, measures of vitamin D metabolic flux were remarkably associated with microbial β-diversity"

"We report robust correlations between the vitamin D metabolites, 1,25(OH)2D and 24,25(OH)2D, and the gut microbiome in 567 older men representing six geographic sites across the United States"

"Those men with higher levels of 1,25(OH)2D had greater α-diversity, even after adjusting for previously characterized determinants of microbial diversity including age, geographical origin, race, PPI, and antibiotic use."

"Serum 25(OH)D is the preferred clinical measure because it is representative of overall body stores of vit D; however, our results suggest it is the regulation of VDM, reflected by active hormone & metabolic ratios rather than body stores that have the most health implications."

"The positive association between diversity metrics and vitamin D activation and catabolism ratios suggests that physiologically normal vitamin D flux is more likely to occur in individuals with healthy microbiomes."

"In summary, we provide strong evidence of important interactions between host vitamin D signaling and the health of the gut microbiome in older men."

More from Robin Monotti FRSA ⭐

Robin Monotti FRSA MA ...
@robinmonotti

BAYES' THEOREM: The basic reason we get so many false positives to COVID19. The disease is so rare that the number of false positives greatly outnumbers the people who truly have the disease: THE MATHS:
https://t.co/oLHyxYJW9H

"Suppose that you are worried that you might have a rare disease. You decide to get tested, and suppose that the testing methods for this disease are correct 99 percent of the time"

"Suppose this disease is actually quite rare, occurring randomly in the general population in only one of every 10,000 people. If your test results come back POSITIVE, what are your chances that you actually have the disease? LESS THAN 1% chance that you have the disease!"

"The basic reason we get such a surprising result is because the disease is so rare that the number of false positives greatly outnumbers the people who truly have the disease"

Say mass testing of the contagious virus was done to 1 million people. In that million, 100 will really have the disease, 99 will be correctly diagnosed as having it. 999,900 of the million will not have the disease, but of those about 9,999 will be false positives! #BayesTheorem

Robin Monotti
@robinmonotti

I have now re-examined this document:

On the 19th March 2020 the WHO released this guidance intended for healthcare workers (HCWs), healthcare managers and IPC teams at the facility level & at national and district/provincial level:https://t.co/C4aV2BnMPj pic.twitter.com/tCk1EyLskV
— Robin Monotti (@robinmonotti) December 21, 2020

It clearly does indicate both the risks of bacterial infection & to prescribe broad spectrum antibiotics as part of treatment:
"Collect blood cultures for bacteria that cause pneumonia and sepsis, ideally before antimicrobial therapy. DO NOT
delay antimicrobial therapy"

"6. Management of severe COVID-19: treatment of co-infections
Give empiric antimicrobials [broad spectrum antibiotics] to treat all likely pathogens causing SARI and sepsis as soon as possible, within 1 hour
of initial assessment for patients with sepsis."

"Empiric antibiotic treatment should be based on the clinical diagnosis (community-acquired
pneumonia, health care-associated pneumonia [if infection was acquired in health care setting] or sepsis), local epidemiology &
susceptibility data, and national treatment guidelines"

"When there is ongoing local circulation of seasonal influenza, empiric therapy with a neuraminidase inhibitor [anti-viral influenza drugs] should
be considered for the treatment for patients with influenza or at risk for severe disease."

Robin Monotti FRSA
@robinmonotti

I have studied the pandemic response of many countries. One of them got a key element right, which resulted in very few deaths: Japan. Their response was to keep people OUT of hospitals. A policy of early home treatment works best, hospitals only for severe cases & NO INTUBATIONS

JAPAN: "No restrictions were placed on residents’ movements, and businesses from restaurants to hairdressers stayed open. No high-tech apps that tracked people’s movements were deployed." RESULT: Among the lowest deaths in the

Saving the NHS simply means providing early treatment kits in pharmacies & avoiding hospitals for Covid19 patients. For Covid19 infections during a pandemic, hospitals are the problem, not the solution.

I have read accounts of people with high fever literally turned away from hospitals, yet being told by phone what treatment protocol to follow. That was the best pandemic response by far, NOT lockdowns.

JAPAN had some of the lowest Covid19 mortality in the world:
-NO LOCKDOWN
-NO TEST AND TRACE
-NO BUSINESS CLOSURES
-NO HOSPITAL FOR NON CRITICAL CASES
-HOME TREATMENT
-HEALTHY DIET
-LOW OBESITY

Robin Monotti
@robinmonotti

Can any MP ask the government why early treatment kits to stop viral replication & infection are not made available cheaply & prescription free in pharmacies as they are in India? Is it lives we want to save or is it Big Pharma profits? Because the two are mutually exclusive.

There could even be competing kits, & the decision which to take could be left to doctors & patients, as happens with most medicines. The problem is that there is not one of these kits available cheaply & prescription free anywhere in the West.

Doxycycline, Ivermectin, Azithromycin, Hydroxychloroquine, Zinc, Vitamin D, Vitamin C, omega-3s, all approved as safe drugs decades ago. This is clearly not an issue of safety. It should be left to a doctor's experience & judgement whether they are effective or not, not academia.

A GP could simply state on his website: of all the kits I recommend Kit Z, then Kit Y etc. No need to wait hours for consultations, as soon as the symptoms are clear the self administered treatment begins, and thousands of lives are saved, as well as hospitals remain underwhelmed

There is no need to go to ER or ICU if people can buy early treatment kits from pharmacies. There is no need for any hospital to be overwhelmed. This problem could be resolved in days. There is simply no political will to save lives as it means to go against Big Pharma profits.

Robin Monotti
@robinmonotti

You know why they didn't try anything like this in the 1970s? Because a generation which remembered WW2 & were still strong enough would not have let them. Politicians were scared of people's reactions back then. They were literally scared for their lives. What happened?

Also, the State did not simply consist of politicians backed by a few regime journalists. There was a much stronger judiciary & military. We would already have seen the military remove deranged politicians leading any country into ruin like this.

The military would have turned against any government which indicated their role was to swab violate children or help inject people with unsafe experimental RNA altering drugs for a virus with a 99.7+% survival rate. They would have taken power by now. What happened?

The most important lesson we can teach our children are the lessons the parents who remembered WW2 taught theirs: how to say NO to a government that is going in a direction you disagree with before it's too late.

This has to start at refusing schools being turned into biosecurity propaganda outposts, asymptomatic testing stations, anti-science brainwashing institutions on masks, repeated swab violation of children's bodies for no gain & to artificially create false positive disruption

More from Category c19

Walter M Chesnut
@Parsifaler

1) THERE IS A VERY REAL, CREDIBLE AND SIGNIFICANT DANGER THAT mRNA SPIKE PROTEIN THERAPIES WILL INDUCE PRION OR PRION-LIKE DISEASE

A paper from 2016 shows that prion and prion-like proteins can also spread and propagate from cell to cell through macropinocytosis. It is also

2) noted that the Spike Protein of SARS-CoV-2 can enter cells through macropinocytosis, without the presence of the entire virion. Given the recent Tweet to me by @endocdoc, where he recently saw a patient develop Creutzfeld-Jakob after COVID-19, the extant paper showing CJD

3) CJD after COVID-19 infection and the recent death of the head of Astra-Zeneca research from CJD should be concerning to all. Especially if he gave himself the AZ therapy during Stage 1 or Stage 2 trials. This would give a possible timeframe for onset.

Again, all Spike Protein

4) mRNA and DNA should be paused until long term animal studies can be

5)

https://t.co/PWOgyPoG5d

Dr Naomi Wolf
@naomirwolf

1/MUST-READ. THIS EXPLAINS EVERYTHING. 1995, "CDC Foundation" created. Allows Pharma to $$$ CDC. $28 million in ONE YEAR from Pharma, $13.5 million in ONE YEAR from @BillGates and Melinda Gates Foundation. CDC IS IN PART INVESTED IN PHARMA via

2/ Thus FUNDING what CDC says to US. I am furious:my state, synagogue "await CDC guidance". Also support vaccines. BUT CDC IS PROFITING AND FUNDED BY BILL GATES AND PHARMA. CDC inflates COVID data too, per peer reviewed study.COMPLETE CIRCLE OF CORRUPTION. Needs criminal charges.

3/ BINGO. TOTAL CORRUPTION. CDC Foundation "invested" ONE BILLION in "lifesaving programs" worldwide; millions of its funding from Pharma, Gates. "PARTNERS" WITH FOR PROFITS (as does NHS dashboard). SO CDC IS INVESTED/ALIGNED W FOR PROFIT COMPANIES and its guidance is corrupted.

Alex Berenson
@AlexBerenson

1/ Let’s talk about vaccine misinformation, @cdcgov style. On Friday the CDC ran a report titled “Reduction in COVID-19 Patients Requiring Mechanical Ventilation Following Implementation of a National COVID-19 Vaccination Program.”

The headline is a lie. No other word will do...

2/ How do I know? From the data in the report itself.

The report, written by three Israeli scientists, intentionally tries to obscure the facts it presents (I’m not entirely sure why it was written at all), but they come out anyway to anyone paying attention...

3/ Your first clue the authors have no interest in presenting the facts honestly comes when they refuse simply to divulge how many people were on ventilators before and after the start of vaccinations on Dec. 19. Instead they focus on the ratio of patients in two age groups...

David Thunder
@davidjthunder

—TAKEAWAY LESSONS FROM PANDEMIC 2020-21: A THREAD—

Below, a few basic lessons I have drawn, as a political philosopher and informed citizen who has made it my business to closely follow political, social, economic, clinical, & epidemiological aspects of the pandemic:

1/ Most mainstream journalists cannot be relied upon to critically uncover, & impartially convey, the facts surrounding a complex & unfolding crisis. If you watch RTE, BBC, or CNN, you are fed naively one-sided stories laced with fear-mongering, misleading use of statistics, etc.

2/ If you wish to inform yourself about a public crisis like this pandemic, you must find commentators who have limited access to mainstream media, good credentials, & arguments that consider a wide range of available evidence. You need to be pro-active about diversifying sources

3/ Reliance by govts upon advisory committees with a clearly one-sided take on the pandemic (eg suppression at all cost) has led to catastrophic outcomes. Govts must diversify their scientific sources & encourage ROBUST scientific debate among their advisors.

4/ Hyper-centralised management of public health is ineffective. Decision-making power must be decentralised so that it can adapt quickly to local conditions. Care homes were badly hurt by top-down mandates that were sluggishly responsive to evolving conditions on the ground.

$Dr. Simon \u30c4$

Dr. Simon ツ
@goddeketal

1/: The inventor of the corona PCR-Test @c_drosten is one of the #protagonists of the current crisis. He is known for involving himself in contradictions. In 2014, he gave a legendary #interview to @wiwo (https://t.co/jzTRh5Suhc) that I will address in this ⬇️short thread⬇️.

2/: The interview is significant because @c_drosten made totally sane statements back then that follow the principle of common sense. Considering his involvement in the "genesis of the current pandemic", his assertions appear in an entirely different

The genesis of a pandemic.

The #Corona crisis began with a panopticon of absurd events, improbable coincidences and outright lies.

Time for a review of the impossibilities.

A thread \U0001f9f5 pic.twitter.com/PLbETVv2p8
— Pace \U0001f642 (@theotherphilipp) February 25, 2021

3/: In 2014, for instance, washing the hands was sufficient against being infected by coronaviruses. Several years he demands measures that destroy national economies and social life worldwide.

4/: Young @c_drosten also severely criticized the fact that Saudi Arabia used the PCR method to detect potential infections. From his point of view, that specific method could lead to many irrelevant cases. Nowadays, his view shifted his opinion towards 'collective punishment'.

5/: Whereas he demands "testing, testing, testing" nowadays and spreads panic and fear via (social) media, he heavily condemned that behaviour of Saudi media in 2014. On top of that, he expressed his concern that medial panic could increase the number of lab tests significantly.

It should be known that the colonialists reached a point that they knew they had 2 leave Kenya since they couldn't handle the Mau Mau war & the world was moving toward accepting independent Africa.However,the colonialists devised an evil scheme that still eats Kenya upto this day

Under this scheme, the colonial state came up with a plan that saw the first crop of chiefly “big men” being empowered financially to take their children to schools and eventually have those children go to England for further studies...

...and eventually providing a ready-made socio-economic & political class whom state power could be entrusted in the post-colonial era.This explains why their children & grandchildren still hold majority of important positions in govt or in the private sector supported by state.

This also explains why children and grandchildren of these homeguards are always given preferential treatment when it comes to government appointments. Wewe na masomo yako you are always asking why you can never get a job in government...yet you're qualified..now you know.

Invest Like the Best
@InvestLikeBest

In 1937, a trucker got frustrated waiting for his cargo to be unloaded. He later sold his company for $1.1 billion.

Here’s the story of how Malcom McLean made a billion dollars and which startup could be following in his footsteps. (Inspired by our episode with @laurabehrenswu)

In the early 1950s, the shipping industry was a dying business.

New York’s docks were handling half as much domestic cargo in the early 1950s as they had been in the depressed 1930s.

In thirty years, no one had invested significant money in coastal shipping.

Why?

As McLean found out, loading ships was difficult and slow.

A truck or train would deliver items to the port. Each item was unloaded separately, recorded, and carried to storage.

When a ship was ready, each item was taken from storage, counted again, and hauled on-board.

The cost of this labor was significant. As one expert at the time explained:

“A four-thousand-mile voyage for a shipment might consume 50 percent of its costs in covering just the two ten-mile movements through two ports.”

Yet, despite the industry’s issues, it felt little pressure to change.

Foreigners were barred from operating domestically. Cartels ran international routes. And gov. subsidies eased the pain of labor costs.

Reshaping the industry needed an outsider.

Enter Malcolm McLean.

Nikita Poojary
@niki_poojary

One of the most successful stock trader with special focus on cash stocks and who has a very creative mind to look out for opportunities in dark times

Covering one of the most unique set ups: Extended moves & Reversal plays

Time for a 🧵 to learn the above from @iManasArora

What qualifies for an extended move?

30-40% move in just 5-6 days is one example of extended move

How Manas used this info to book

The stock exploded & went up as much as 63% from my price.

Closed my position entirely today!#BroTip pic.twitter.com/CRbQh3kvMM
— Manas Arora (@iManasArora) June 22, 2020

Post that the plight of the

What an extended (away from averages) move looks like!!

If you don't learn to sell into strength, be ready to give away the majority of your gains.#GLENMARK pic.twitter.com/5DsRTUaGO2
— Manas Arora (@iManasArora) June 24, 2020

Example 2: Booking profits when the stock is extended from 10WMA

10WMA =

#HIKAL

Closed remaining at 560
Reason: It is 40+% from 10wma. Super extended

Total revenue: 11R * 0.25 (size) = 2.75% on portfolio

Trade closed pic.twitter.com/YDDvhz8swT
— Manas Arora (@iManasArora) July 2, 2021

Another hack to identify extended move in a stock:

Too many green days!

Read

When you see 15 green weeks in a row, that's the end of the move. *Extended*

Simple price action analysis.#Seamecltd https://t.co/gR9xzgeb9K
— Manas Arora (@iManasArora) August 26, 2019