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Sufficient niacin supply: the missing puzzle piece to COVID-19, and beyond?

Dmitry Kats, Ph.D., M.P.H.*

* Correspondence: [email protected]

FULL MANUSCRIPT BELOW

 Abstract: Definitive antiviral properties are evidenced for niacin, i.e., nicotinic acid (NA), as coronavirus disease 2019 (COVID-19) therapy for both health restoration and prevention, to the level that progression of COVID-19 pathology may follow as an intrinsic function of NA
supply. This detailed investigation proposes thorough disentanglement of how the downstream inflammatory propagation of ensuing severe acute respiratory virus 2 (SARS-CoV-2) infection can either be prohibited or reversed upstream out the body to expeditiously restore health with
well-tolerated dynamic supplementation of sufficient NA (i.e., ~1-3 grams per day). Culmination of this research leads to realization of the potentially ubiquitous therapeutic and preventive powers of NA against inflammatory disease, in general.
Despite continued intensive efforts to mitigate the spread and burden of coronavirus disease 2019 (COVID-19) in populations, implications for the future remain unclear. Encouraging nonetheless is the vast understanding of the disease gained as a result of the unprecedented level
of collective rigor dedicated by scientists across the globe. Synthesis of the recent advancements made from such accelerated investigation augurs particularly dynamically supplied, sufficient dosage of immediate-release nicotinic acid (NA) as a strikingly promising therapeutic
antiviral agent to overcome pending challenges.
Motivation for this original investigation into specifically NA supply as COVID-19 treatment was sparked by deduction of the possibility that the counterintuitive link so dramatically and consistently observed (see @phil_w888's page) of (cigarette/tobacco-nicotine) smoking
against ensuing severe acute respiratory virus 2 (SARS-CoV-2) infection may be explained by the fact that nicotine is oxidized into NA during the combustion process (at a rate of ~60 mg/day for a pack-a-day smoker) [1].

1.
https://t.co/PEhONXdY8D
Further, elucidation following extensive review of the developing relevant literature points to an exclusive ability for sufficiently supplied NA (upon which the human species continues dynamically to be thoroughly deficient through diet)—through its unique, intricate,
endothermic biochemical processing—to induce a thermodynamic flush response that appears to be mechanistically capable of reversing/restoring health from, and/or protecting against an assortment of inflammatory-induced diseases of acute and prolonged nature, such as COVID-19.
In turn, this may also explain the consensus body of relevant literature evidencing potent therapeutic and/or protective properties for sufficient dosage of immediate-release NA across the disease spectrum, including but not limited to demonstrated successful application against:
cardio-metabolic/vascular conditions [2-13],

2.
https://t.co/8rxHM3n7a6
3.
https://t.co/CZvGy26eBu
4.
https://t.co/rDqyftDdoH
5.
https://t.co/ea6UZlAmgC
6.
https://t.co/SQ5KdPTNMz
7.
https://t.co/wAF8TpH1YF
8.
https://t.co/8Ce2Jzkv4J
9.
https://t.co/OUDv2lIg1e
10.
https://t.co/2rhLhweTmc
11.
https://t.co/SVo7zPDxMT
12.
https://t.co/N3LxcPusOw
13.
https://t.co/s6GcrsBlZs
arrhythmia/thrombosis [14-17],

14.
https://t.co/Yd1l8ohXJe
15.
https://t.co/y6fnsR4D40
16.
https://t.co/nkbz4tyjaT
17.
https://t.co/iTmD8Z4LdJ
hepatic as well as renal function [3,18],

3.
https://t.co/CZvGy26eBu
18.
https://t.co/9gxY0cQdIX
pulmonary/lung injury [19],

19.
https://t.co/JgmKGaKmHC
viral/infectious diseases including influenza [20-22]

20.
https://t.co/EqyqJKq1BJ
21.
https://t.co/FKLEj5sYZw
22.
https://t.co/kpG0U2vKFm
and retroviruses like HIV/AIDs [23-26]

23.
https://t.co/d58DAM88q1
24.
https://t.co/uZ9x2RSHqc
25.
https://t.co/giGJ5qU6uv
26.
https://t.co/JPCoxeApxx
as well as tuberculosis [27],

27.
https://t.co/Sfs55oUoiW
cancers [28-31],

28.
https://t.co/7iAqZ4ZAW5
29.
https://t.co/tJ2a2BvqPd
30.
https://t.co/VibTLjGUzk
31.
https://t.co/JkGfYuYZKO
thyroid-related disease [32,33],

32.
https://t.co/zhl3noVrJN
33.
https://t.co/ONYf424Sm5
arthritic conditions [34],

34.
https://t.co/SxrWjhJ2L1
neurodegeneration/dementia/aging [35-41],

35.
https://t.co/GzJAezdb8b
36.
https://t.co/Nut6Kcczj9
37.
https://t.co/eXaSocerEE
38.
https://t.co/sK94Gt9zmU
39.
https://t.co/Cq4TxcUtJu
40.
https://t.co/qLk1QYtVBu
41.
https://t.co/nqFbRsYmWG
auto-immune disorders [37,42],

37.
https://t.co/eXaSocerEE
42.
https://t.co/B2JAxh0DFv
birth defects [43]

43.
https://t.co/JJZdQT4YVB
and pre- or post-natal induced impairment of immune and neurodevelopmental function [44,45],

44.
https://t.co/6OzCDPbwc6
45.
https://t.co/xUqhLmeW51
mental health disorders [46-49],

46.
https://t.co/LpESkUHO6l
47.
https://t.co/cQy54wXHHY
48.
https://t.co/EWyYzSCYWS
49.
https://t.co/OXDZG4RgQ3
mast cell conditions [50,51],

50.
https://t.co/6BFTTMOTtO
51.
https://t.co/kcF7dc9q0g
genetic disorders [43,52,53],

43.
https://t.co/JJZdQSNo43
52.
https://t.co/p3YzYz7sWe
53.
https://t.co/n7qzprgNUc
asthma [54],

54.
https://t.co/F2x9hKMH6X
dermatitis/eczema/psoriasis [55-60],

55.
https://t.co/AJqsFhaMZf
56.
https://t.co/c5R7NUIixz
57.
https://t.co/VpSmwv7EBW
58.
https://t.co/e1Oyh17hlY
59.
https://t.co/mAwW8dZaSS
60.
https://t.co/VE5S780TUn

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