"expert reaction to a preprint reviewing the evidence on the origins of SARS-CoV-2"
https://t.co/6kG6rstweP
1. Some useful, albeit not fully developed, critiques of:
“The Origins of SARS-CoV-2: A Critical Review"
https://t.co/C9TyRyqHUr
have just been published here:
https://t.co/qCmzGCzRxn
by members of DRASTIC & others
@angoffinet @BahulikarRahul @MonaRahalkar @gdemaneuf
"expert reaction to a preprint reviewing the evidence on the origins of SARS-CoV-2"
https://t.co/6kG6rstweP
His critique focuses on:
1. RaTG13
2. Enhanced adaptation to the human host
https://t.co/eW8b2iK5xe
https://t.co/xrjpN1NxpO
1. https://t.co/YJ50huifly
one of the authors (Stuart Neil) then claimed
"Didn’t N501Y come up in ACE2 TG mice too?
https://t.co/HscNSEKdrZ
All your natural origin friends in one place ;)
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) July 7, 2021
Origins of SARS-CoV-2: A Critical Reviewhttps://t.co/j4A4rtmi8S
via @Topo_Ligio
Fallacy of the "straw mouse", denying evolution in wild type mice, when the claim is actually that it may have "evolved" in hACE2 mice, NOT wild mice. pic.twitter.com/7LCnSAhw6g
https://t.co/ldzuAMDiF9
Human lung xenograft & adenovirus hACE2 mice need to be immunosuppressed/deficient e.g. SCID or Rag1-2 KO2 mice, so as not to reject the allograft cells & transgenic ACE2.
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) July 8, 2021
So, why do you think N501Y would emerge in TG hACE2 mice without a functional immune system or mouse ACE2?
https://t.co/OaLzUfIPuA
A thread with papers to educate Stuart here:
https://t.co/BFVxXlVKj4
Didn\u2019t N501Y come up in ACE2 TG mice too? https://t.co/cRR1qlTUtB
— Stuart Neil (@stuartjdneil) July 7, 2021
https://t.co/k93d6gVR8s
I guess it was his way of admitting he was wrong about N501Y?
Are you just going to quote the entire history of TG mice for CoV research?
— Stuart Neil (@stuartjdneil) July 7, 2021
We know they had Th mice for recombinant CoV infection.
But it\u2019s all irrelevant
They needed to have the right virus. And thus far is there is zero evidence that they did.
https://t.co/Syn3CNd5ne
So maybe you can tell me why you get adaptive mutations in mouse passage outside spike? Those should happen in Tg mice too. Where are they?
— Stuart Neil (@stuartjdneil) July 7, 2021
https://t.co/cH4jY6HOfe
https://t.co/I90OOCJg7o
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) July 8, 2021
I suspect that the reason for the emergence of N501Y in this specific experiment is that the balb/c mice used in the experiment were non hACE2 mice and immunocompetent mice.
https://t.co/ZIPRFOHDGE
It's a simple point, that you are wrong about N501Y
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) July 10, 2021
"Taken together, these patterns of detectable selection suggest that the adaptive value of signature 501Y lineage RBD mutations may have only manifested after a selective shift that occurred shortly before November 2020"
The Straw Lab Fallacy
https://t.co/kS9wCBkgvr
They haven't even done the basic research.
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) July 11, 2021
They conjured up a straw lab, the bsl4 lab
Most bat coronavirus work was done at the older complex in xiaohongshan. The labs (plural) and their locations are listed here along with documented biosafety issues:https://t.co/ewo9oZUuqU
A long thread by @Rossana38510044 debunking the claims in "Origins of SARS-CoV-2: A Pathetic Review"
https://t.co/Un0h4cm3vi
Saved:
https://t.co/8eDdbKWdqf
Archived:
https://t.co/8bfaU4nWXo
That was a surprise. So many well-known supporters of SARS2\u2019s natural origin join forces to publish an opinion piece in\u2026Zenodo \U0001f602https://t.co/led9ZcIokp
— Rossana Segreto (@Rossana38510044) July 8, 2021
A response to “The Origins of SARS-CoV-2: A Critical Review”
https://t.co/QrqL9DlBGh
Archived:
https://t.co/UA29u7D3v0
More from Billy Bostickson 🏴👁&👁 🆓
@jimmy_wales Thanks for replying!
1/. I will make a thread here with some details so you can see for yourself how a small clique of pro Chinese gatekeeping editors and admins have bullied editors, throttled dissent and gamed the system to impose their POV.
2/. I am a supporter of
3/. This is what I ended up feeling about WP after
4/. Some disturbing
5./ Some members of the gatekeeping
1/. I will make a thread here with some details so you can see for yourself how a small clique of pro Chinese gatekeeping editors and admins have bullied editors, throttled dissent and gamed the system to impose their POV.
2/. I am a supporter of
I just donated to #Wikipedia. Help keep it free! #keepitfree http://t.co/CFn4E1p5
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) December 6, 2012
3/. This is what I ended up feeling about WP after
That was a very depressing read, one of the reasons I avoid @Wikipedia like the plague.
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) September 26, 2020
Full of pompous, self righteous pricks with rule books instead of brains, all pretending to be calm, collected and unbiased while secretly frothing at the mouth with their own slanted views. https://t.co/I62XqKt0tB
4/. Some disturbing
Who the hell is writing these wikipedia articles lately, Peter Daszak?https://t.co/nIP3rMr7Gx pic.twitter.com/9KE0ORIi1V
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) November 17, 2020
5./ Some members of the gatekeeping
You should read the Talk Pagehttps://t.co/3CjCZWLB7k
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) November 17, 2020
User:Henipa
Henipa is a Canadian-American virologist who specializes in hanta- and henipaviruses.
M\xf2ji\u0101ng virus is my child.
Henipa is clinically insane, these virologists seem to delight in deception with huge axes to grind pic.twitter.com/E0bcwHyeYc
Same covid-19 mutations are appearing in different places, which may or may not be strange....
41,000 mutations documented in 880 lineages.
Most in spike protein
What explains it?
https://t.co/MvHzUb4peo
https://t.co/PAwgC3lgsO
https://t.co/f9rnyFI0vq
https://t.co/wAlyNzuI0W
41,000 mutations documented in 880 lineages.
Most in spike protein
What explains it?
https://t.co/MvHzUb4peo
1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice https://t.co/TNE4tuLkqN
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) February 18, 2021
https://t.co/PAwgC3lgsO
2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2 https://t.co/B3eR764c1Z
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) February 18, 2021
https://t.co/f9rnyFI0vq
1. Reversion of molecularly engineered, partially attenuated, very virulent infectious bursal disease virus during infection of commercial chickenshttps://t.co/wOg1Ekl3Xp
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) February 24, 2021
2. Reversion to Virulence of Attenuated Canine Distemper Virus In Vivo and In Vitrohttps://t.co/xhjOEYEWTY
https://t.co/wAlyNzuI0W
3. pathogenic reversion of simian immunodeficiency virus SIVmac239Deltanef increases viral replicationhttps://t.co/jHmujgDVAC
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) February 24, 2021
@EricTopol @NBA @StephenKissler @yhgrad B.1.1.7 reveals clearly that SARS-CoV-2 is reverting to its original pre-outbreak condition, i.e. adapted to transgenic hACE2 mice (either Baric's BALB/c ones or others used at WIV labs during chimeric bat coronavirus experiments aimed at developing a pan betacoronavirus vaccine)
@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2
@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj
@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 30, 2021
"we generated a mouse model expressing hACE2 by using CRISPR/Cas9 knockin technology. In comparison with wild-type C57BL/6 mice, both young & aged hACE2 mice sustained high viral loads... pic.twitter.com/j94XtSkscj
@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2
1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 2, 2021
2 papers:
Human\u2013viral molecular mimicryhttps://t.co/irfH0Zgrve
Molecular Mimicryhttps://t.co/yLQoUtfS6s https://t.co/lsCv2iMEQz
@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj
@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
1/ BIO TERROR! History, Present and Future....
Human experimentation, modern nightmares and lone madmen in the twentieth
2/ BIO TERROR! History, Present and Future....
The History of Biological Weapons Use:
What We Know and What We Don't. W. Seth
3/ BIO TERROR! History, Present and Future....
Biological Warfare in the 17th Century
W. Seth Carus
https://t.co/GEnU8fUC3m
and
Biological Warfare Plan in the 17th Century—the Siege of Candia,
4/ BIO TERROR! History, Present and Future....
Biological Warfare at the 1346 Siege of Caffa
https://t.co/BQZ8riLq1o
The 'Hittite Plague', an Epidemic of Tularemia and the First Record of Biological
5/ BIO TERROR! History, Present and Future....
The Plague of Athens: An Ancient Act of Bioterrorism?
https://t.co/YjiG4PspCA
Applying Modern Immunology to the Plague of
Ancient
Human experimentation, modern nightmares and lone madmen in the twentieth
2/ BIO TERROR! History, Present and Future....
The History of Biological Weapons Use:
What We Know and What We Don't. W. Seth
3/ BIO TERROR! History, Present and Future....
Biological Warfare in the 17th Century
W. Seth Carus
https://t.co/GEnU8fUC3m
and
Biological Warfare Plan in the 17th Century—the Siege of Candia,
4/ BIO TERROR! History, Present and Future....
Biological Warfare at the 1346 Siege of Caffa
https://t.co/BQZ8riLq1o
The 'Hittite Plague', an Epidemic of Tularemia and the First Record of Biological
5/ BIO TERROR! History, Present and Future....
The Plague of Athens: An Ancient Act of Bioterrorism?
https://t.co/YjiG4PspCA
Applying Modern Immunology to the Plague of
Ancient
1. Omicron Thread - A Compilation of Opinions
"finally, the time has slip and slid its slimy course through to us - and we're the vicious bastards of the new generation. we do not relent, and we should not be held to account for our ancestral faults"
https://t.co/mhJO6yOQRE
2. The Letter Chosen by the WHO
"It's amazing that the Xi variant seems to have somehow managed to evade detection..."
via @readomain
Why 'Omicron', Not 'Nu' or 'Xi'?
WHO Says Two Letters in Greek Alphabet Jumped to 'Avoid Stigma'
https://t.co/xnGR9XK2tF
3. The Omicron variant has been found in nearly every province of South Africa, as well as Botswana, Belgium, Israel, UK and Hong Kong.
This month, Israel held an exercise, The “Omega Exercise”, meant to prepare for a hypothetical, new COVID-19
4. Omicron Infographic
(appeared in Germany and Italy now)
https://t.co/oNFYBH1F1o
5. Overview of Omicron (B.1.1.529) from @nicd_sa
https://t.co/HN9csJqK0z
"finally, the time has slip and slid its slimy course through to us - and we're the vicious bastards of the new generation. we do not relent, and we should not be held to account for our ancestral faults"
https://t.co/mhJO6yOQRE
Here is how B.1.1.529 (#Omicron #B11529) compares to Alpha, Beta, Gamma, Delta variants.
— nference (@_nference) November 27, 2021
Omicron has highest novel Spike mutations including striking cluster on the "crown" suggesting significant selection pressure & antigenic distinction from prior strains
(Credits: nference) pic.twitter.com/4oZQbjhbG8
2. The Letter Chosen by the WHO
"It's amazing that the Xi variant seems to have somehow managed to evade detection..."
via @readomain
Why 'Omicron', Not 'Nu' or 'Xi'?
WHO Says Two Letters in Greek Alphabet Jumped to 'Avoid Stigma'
https://t.co/xnGR9XK2tF
3. The Omicron variant has been found in nearly every province of South Africa, as well as Botswana, Belgium, Israel, UK and Hong Kong.
This month, Israel held an exercise, The “Omega Exercise”, meant to prepare for a hypothetical, new COVID-19
4. Omicron Infographic
(appeared in Germany and Italy now)
https://t.co/oNFYBH1F1o
5. Overview of Omicron (B.1.1.529) from @nicd_sa
https://t.co/HN9csJqK0z
Prof @Tuliodna is giving an insightful overview of the #NewVariant #B11529 pic.twitter.com/VnFBrj2pOT
— NICD (@nicd_sa) November 25, 2021
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Neo-nazi group #PatriotFront held a photo op in #Chicago last weekend & is currently marching around #DC so it's as good time as any to compile a list of their identified members for folks to watch for
Who are these chuds?
Patriot Front broke away from white nationalist org Vanguard America following #unitetheright in #charlottesville after James Alex Fields was seen with a VA shield before driving his car into a crowd, murdering Heather Heyer & injuring dozens of others
Syed Robbie Javid a.k.a. Sayed Robbie Javid or Robbie Javid of Alexandria,
Antoine Bernard Renard (a.k.a. “Charlemagne MD” on Discord) from Rockville, MD.
https://t.co/ykEjdZFDi6
Brandon Troy Higgs, 25, from Reisterstown,
Who are these chuds?
Patriot Front broke away from white nationalist org Vanguard America following #unitetheright in #charlottesville after James Alex Fields was seen with a VA shield before driving his car into a crowd, murdering Heather Heyer & injuring dozens of others
Syed Robbie Javid a.k.a. Sayed Robbie Javid or Robbie Javid of Alexandria,
Happy Monday everyone :-) Let's ring in September by reacquainting ourselves with Virginia neo-Nazi and NSC Dixie affiliate Sayed "Robbie" Javid, now known by "Reform the States". Robbie is an explicitly genocidal neo-Nazi, so lets get to know him a bit better!
— Garfield but Anti-Fascist (@AntifaGarfield) August 31, 2020
CW on this thread pic.twitter.com/3gzxrIo9HD
Antoine Bernard Renard (a.k.a. “Charlemagne MD” on Discord) from Rockville, MD.
https://t.co/ykEjdZFDi6
Brandon Troy Higgs, 25, from Reisterstown,
1/ Here’s a list of conversational frameworks I’ve picked up that have been helpful.
Please add your own.
2/ The Magic Question: "What would need to be true for you
3/ On evaluating where someone’s head is at regarding a topic they are being wishy-washy about or delaying.
“Gun to the head—what would you decide now?”
“Fast forward 6 months after your sabbatical--how would you decide: what criteria is most important to you?”
4/ Other Q’s re: decisions:
“Putting aside a list of pros/cons, what’s the *one* reason you’re doing this?” “Why is that the most important reason?”
“What’s end-game here?”
“What does success look like in a world where you pick that path?”
5/ When listening, after empathizing, and wanting to help them make their own decisions without imposing your world view:
“What would the best version of yourself do”?
Please add your own.
2/ The Magic Question: "What would need to be true for you
1/\u201cWhat would need to be true for you to\u2026.X\u201d
— Erik Torenberg (@eriktorenberg) December 4, 2018
Why is this the most powerful question you can ask when attempting to reach an agreement with another human being or organization?
A thread, co-written by @deanmbrody: https://t.co/Yo6jHbSit9
3/ On evaluating where someone’s head is at regarding a topic they are being wishy-washy about or delaying.
“Gun to the head—what would you decide now?”
“Fast forward 6 months after your sabbatical--how would you decide: what criteria is most important to you?”
4/ Other Q’s re: decisions:
“Putting aside a list of pros/cons, what’s the *one* reason you’re doing this?” “Why is that the most important reason?”
“What’s end-game here?”
“What does success look like in a world where you pick that path?”
5/ When listening, after empathizing, and wanting to help them make their own decisions without imposing your world view:
“What would the best version of yourself do”?
I’m torn on how to approach the idea of luck. I’m the first to admit that I am one of the luckiest people on the planet. To be born into a prosperous American family in 1960 with smart parents is to start life on third base. The odds against my very existence are astronomical.
I’ve always felt that the luckiest people I know had a talent for recognizing circumstances, not of their own making, that were conducive to a favorable outcome and their ability to quickly take advantage of them.
In other words, dumb luck was just that, it required no awareness on the person’s part, whereas “smart” luck involved awareness followed by action before the circumstances changed.
So, was I “lucky” to be born when I was—nothing I had any control over—and that I came of age just as huge databases and computers were advancing to the point where I could use those tools to write “What Works on Wall Street?” Absolutely.
Was I lucky to start my stock market investments near the peak of interest rates which allowed me to spend the majority of my adult life in a falling rate environment? Yup.
Ironies of Luck https://t.co/5BPWGbAxFi
— Morgan Housel (@morganhousel) March 14, 2018
"Luck is the flip side of risk. They are mirrored cousins, driven by the same thing: You are one person in a 7 billion player game, and the accidental impact of other people\u2019s actions can be more consequential than your own."
I’ve always felt that the luckiest people I know had a talent for recognizing circumstances, not of their own making, that were conducive to a favorable outcome and their ability to quickly take advantage of them.
In other words, dumb luck was just that, it required no awareness on the person’s part, whereas “smart” luck involved awareness followed by action before the circumstances changed.
So, was I “lucky” to be born when I was—nothing I had any control over—and that I came of age just as huge databases and computers were advancing to the point where I could use those tools to write “What Works on Wall Street?” Absolutely.
Was I lucky to start my stock market investments near the peak of interest rates which allowed me to spend the majority of my adult life in a falling rate environment? Yup.
