1. Omicron Thread - A Compilation of Opinions

"finally, the time has slip and slid its slimy course through to us - and we're the vicious bastards of the new generation. we do not relent, and we should not be held to account for our ancestral faults"

https://t.co/mhJO6yOQRE

2. The Letter Chosen by the WHO

"It's amazing that the Xi variant seems to have somehow managed to evade detection..."

via @readomain

Why 'Omicron', Not 'Nu' or 'Xi'?

WHO Says Two Letters in Greek Alphabet Jumped to 'Avoid Stigma'

https://t.co/xnGR9XK2tF
3. The Omicron variant has been found in nearly every province of South Africa, as well as Botswana, Belgium, Israel, UK and Hong Kong.

This month, Israel held an exercise, The “Omega Exercise”, meant to prepare for a hypothetical, new COVID-19 variant

https://t.co/c2PoTfJiIE
4. Omicron Infographic

(appeared in Germany and Italy now)

https://t.co/oNFYBH1F1o
5. Overview of Omicron (B.1.1.529) from @nicd_sa

https://t.co/HN9csJqK0z
6. Timeline of Omicron from @nicd_sa

Note:

@Clucky92864053 points out that this variant of the virus itself was first identified back in July 2021

https://t.co/13V16t1V4u
7. Minimal FAQ from @nicd_sa (26 November 2021)

https://t.co/fycSalwxXr
9. Opinion of Trevor Bedford @trvrb

He considers that the extremely long branch (>1 year) indicates continual evolution in a chronically infected individual before spilling back into the population.

https://t.co/uIDzJH65vO

Archived thread:

https://t.co/eOelixoKeF
10. Opinion of @trvrb (2)

He highlights the striking accumulation of mutations in the S1 domain of the spike protein.

He concludes that the presence of host derived RNA insertion from TMEM245 gene points to evolution within humans rather than spillback from animal population
11. Spreading quickly

https://t.co/YgG1J7z6sc

with a doubling time of 4.8 Days

https://t.co/CP5TUo5ffy
12. Opinion of @ydeigin

"Looks like the new strain was either incubated in an immunocompromized person for months or serially passaged in a lab in the presence of convalescent plasma"

https://t.co/Jbf1f1rkIF
13. Some facts from Dr Emma Hodcroft @firefoxx66

"making it hard with current sequences to tell much about the evolutionary history"

https://t.co/4Cht9WLzS8

and

https://t.co/kut28XyFh3
14. Phylogenetic analysis of SARS-CoV-2 clusters in their international context - cluster 21K

Maintained by Emma Hodcroft @firefoxx66

https://t.co/IP5CxFROa5
15. Krammer @florian_krammer asks a question

"Do you think it is plausible that this variant was mostly generated within one host with a persistent infection?"
16. Rewind to the South African HIV patient

https://t.co/P11iawQReP
17. Earlier Concerns

Persistent SARS-CoV-2 infection and intra-host evolution in association with advanced HIV infection

https://t.co/lqffiIAyNI
and
https://t.co/RMZ2y9i23I

As COVID-19 collides with HIV/AIDS, the pandemic may be taking an ominous turn

https://t.co/RMZ2y9i23I
18. Rumours abound - Molnupiravir (1)

@veryvirology and @marc_g_wathelet point to a possible connection to recent trials with Merck and Ridgeback’s Investigational Oral Antiviral "Molnupiravir" in South Africa

https://t.co/g8kyKdDxek

and

https://t.co/jFUTPw5pur
19. But according to Daily Maverick (SA) (18/11/21)

"New antiviral pills to treat Covid unlikely to be made available in South Africa for some time"

https://t.co/UJcDqDCpCl

and the trials took place at 170 sites in many countries not just South Africa.

https://t.co/5GybZu9aHE
20. Also rumours of Lab Leaks ;)

University of Pretoria BSL3

https://t.co/Z2mX3FKk8F
21. BSL3 and BSL4

https://t.co/JwsITyy7JE
22. The Mutations

Page 18:

SARS-CoV-2 variants of concern and variants under investigation in England

Technical briefing 29 - 26 November 2021

https://t.co/vgoktp62Ly
23. Significance of the Mutations

For some, these mutations support lab leak theory (Wuhan), for example @zhiyanle

"the mutations again proves SARS-2 is lab-made. Natural Cov needs 50 years for 1100BP mutation; but lab-made nCov can have 5 times more mutation just in a year"
24. Others Disagree, for example @_b_meyer

https://t.co/6MyarZHKfy
25. Comments

https://t.co/HkOAxcCWb6
26. @_b_meyer rightly chastised by @notoriousFIL

in a complex but very interesting thread related to the argument that "the 681 Proline before the FCS of SARS-COV-2 was somehow "suboptimal"

https://t.co/n9CBtpL9gP

We def need more people like @notoriousFIL in #DRASTIC
27. Two specific tweets

1. The argument that the 681 Proline was somehow "suboptimal" relies on misunderstanding about the conditionality its presence given the rest of the Spike protein structure

https://t.co/880zuh33Pp

2.
https://t.co/Wn523bt9nu
28. Back to Omicron (Opinion of @JCPEREZCODEX )

Fibonacci Sins!

He identifies a "RUPTURE" that no longer follows a pattern of virus-to-host adaptation, and thus suspects lab manipulation

https://t.co/fU5L8xNPoB

and

https://t.co/fU5L8xNPoB
29. @jcbarret dissects the "Omicron" mutations

https://t.co/GtnsW4FOTZ
30. @jbloom_lab on the "Omicron" Mutations

He explains how mutations in #SARSCoV2 Nu variant (B.1.1.529) will affect polyclonal and monoclonal antibodies targeting RBD.

https://t.co/a6kap9CFtt
31. @theodora_nyc responds to @jbloom_lab

https://t.co/3nUrKzSJOv

(experiments in Sep 2021 were with VLPs)

SARS-CoV-2 polyclonal neutralizing antibody escape

https://t.co/OhHsjPhJxg

"Nature performed the same experiment as we did with a lot more samples"
33. @florian_krammer is a worried virologist

"The mutations in Omicron which seem to wipe out the majority of neutralizing antibody epitopes are very worrisome. Combined with the apparent fitness of the virus, this could be a problem"

https://t.co/6NaGupsEpm
34. But is Omicron just a "storm in a teacup"?

South African Medical Association Says Omicron Variant Causes 'Mild Disease'

https://t.co/qPsfZeVRfx
35. Short Video Interview with Angelique Coetzee

(Medical Health "Chief" of South Africa)

https://t.co/XRgw2xyqYA
36. From a storm in a teacup to a blessing?
via @DMoffin

"Wouldn't artificially creating a highly infectious virus with very low pathogenicity, & therefore outcompeting more deadly variants, be most genius thing researchers could do to end the pandemic?
https://t.co/hDYkUAxsSv
37. Keep up to date with Omicron @nytimes

Great graphics by Jonathan Corum @13pt

and @carlzimmer

Tracking Omicron and Other Coronavirus Variants

https://t.co/dnV79zYAgy
unroll Omicron @threadreaderapp
Update 1

People currently arguing about the positive outlook

https://t.co/PlyVbxzE4g
Update 2 via @phil_aussie and a great idea

https://t.co/2unHFeVJhT
Update 3 Thanks @AGHuff

The "UK " Diplomatic Connection...

https://t.co/gfl1PKdtA2
Update 4

Opinion of Geert Vanden Bossche @GVDBossche

Quite a short opinión piece ;) mostly looking at ADE and vaccines

https://t.co/INWSQpwbds
Update 5 by Moritz Gerstung @MoritzGerstung

A thread on Omicron mainly focusing on HIV

https://t.co/v5fQDRQxF3

https://t.co/TwinU53oDe
Update 6 from Mia Malan @miamalan

early look at the identified mutations

https://t.co/es8ARBwBaW
Update 7

Although some conclude that accumulation of mutations in a single immunocompromised patient (perhaps AIDS) is plausible, @daoyu15 disagrees

https://t.co/Ml4Ribsi1q
and
https://t.co/ovY4nSVPqD
and
https://t.co/ZcRa4vzkcd
Update 8 - @P_J_Buckhaults is surprised

https://t.co/WmHXxn2SuR
Update 9 - @ydeigin moves further to a lab leak

https://t.co/i2P1Kp0goU
Update 10 - @NPRGoatsandSoda

https://t.co/ctGaoQxBfO
Update 11 - "Weird" Omicron by @EricTopol

https://t.co/tK9yVPcsnO
Update 12 - Mega Omicron Thread by...

Hans Kristian "Lazarus" Andersen @K_G_Andersen2

Thinks it's "odd" and suspects "reverse zoonosis" possibly from rodents...

https://t.co/NlhSgz1D6j
Update 13 - @mroliverbarnes

https://t.co/QO237D88Uj
Update 14 - Reinfections surging?

"there may be an increased risk of reinfection with Omicron (ie, people who have previously had COVID-19 could become reinfected more easily with Omicron), as compared to other variants of concern"

https://t.co/zZrPal1cF1
Update 15 - Reinfections (2)

"Previous infection used to protect against Delta but now with Omicron that doesn't seem to be the case," said Anne von Gottberg, microbiologist at South Africa's National Institute for Communicable Diseases.

https://t.co/hcOVwrEhIY
Update 16 - Reinfections (3)

"We monitored these reinfections for Beta & Delta wave & we didn't see increase in reinfections above what we expect when the force of infection changes - when the wave stops. However, we are seeing an increase for Omicron"

https://t.co/3XkPmnuvLZ
Update 17 - Rodents?

Humanised Mice and Rodents with HIV?

Interestingly, Anderson mentions similar mutations in rodents as supporting his reverse zoonosis hypothesis:

https://t.co/a4GhCIIETW

But stops there.
Update 18 - Rodent and other animal Mutations

by Robert Garry and Bill Gallaher

Mutations arising in SARS-CoV-2 spike on sustained human-to-human transmission and human-to-animal passage

https://t.co/LiduigHlC7
Update 19 - Updated Mutations including Omicron

Rats and Mice abound!

Note hACE2 mice in grey

https://t.co/daNwvmArj8
Update 20 - HIV Rodents?

Now as is well known, HIV cannot infect mice, rats..

BUT

Humanized mouse models currently available are capable of replicating both HIV-1 & 2 exclusively in human immune cells that are present both in the periphery & in tissues
https://t.co/owQ8TeuElE
Update 21 - Humanised Mouse Models (2)

Humanized mouse models like the T cell only mouse or the myeloid only mouse permit the analysis of HIV biology in individual cell types.

systemic reconstitution of humanized mice with human cells permit in vivo analysis of HIV persistence
Update 22 - Sample HIV Mouse papers

1. A mouse model for study of systemic HIV-1 infection, antiviral immune responses, and neuroinvasiveness (USA 2005)
https://t.co/KPCj2KOOpi
Update 23 - Sample HIV Mouse papers

2. Rectal Transmission of Transmitted/Founder HIV-1 Is Efficiently Prevented by Topical 1% Tenofovir in BLT Humanized Mice (UNC, 2013)

https://t.co/hUFGtMKjy7
Update 24 - Sample HIV Mouse papers

3. Mucosal HIV-1 transmission and prevention strategies in BLT humanized mice (UNC)

https://t.co/u8fZhWgoT1
Update 25 - Rats and HIV (2007)

By @sciencecohen

"now scientists have shown that a genetically engineered rat is susceptible enough to HIV infection that it may be able to help evaluate some AIDS drugs"

https://t.co/OeCW6YK4ZD
Update 26. SARS COV 2 in Mice

As is known, unlike the first identified strain, new SARS-CoV-2 VOCs are capable of infecting animal models (mice) in the lab.

https://t.co/SHhnbGx3Gb

Paper

B1.351 & P.1 variants extend SARS-CoV-2 host range to mice
https://t.co/SHZWjXntWk
Update 27 - ABSL2, University of Cape Town

Research on HIV vaccines & helminth parasite infested Mice (2018)

Note:

In this specific study the BALB/c mice did not have HIV

Chronic schistosomiasis suppresses HIV-specific responses in a mouse model

https://t.co/ye13mpwHRW
Update 28 - HIV Research with Mice (Cape Town)

Anna-Lise Williamson

Department of Pathology, Faculty of Health Sciences, University of Cape Town
Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town

https://t.co/dkMEuywLUG
Update 29 - Groundhog Day (2020)

"One hypothesis for emergence of this lineage, given the many mutations relative to background mutation rate of SARS-CoV-2, is that it arose via intra-host evolution in 1 or more people with prolonged viral replication"

https://t.co/hH5d6yMkh1
Update 30 - December 22, 2020

immunosuppressed patient hypothesis discarded

multiple individuals?

"If evolution within long-term infections were the explanation for the evolution of this lineage then it supposes a transmission chain that passes through multiple individuals"
Update 31 - Garry & Gallaher - Rodent Mutations

"7 (mutations) are associated with rodent adaptation — changes that allow the virus to infect mice, rats & related species. All 7 of those mutations are in Omicron"

https://t.co/HT04EcDp5B
Update 32

Oh my Cron, this will be the never ending thread!
Update 33 - @DrJlieberman

1. Key mutations in Omicron (NTD deletions around 144, 478K, 484A, 501Y) emerged independently in an immunosuppressed patient https://t.co/lwBXDJYfNv

2. Mapping of viral mutations that escape antibodies used to treat COVID-19
https://t.co/d6N7wIfh9k
Update 34 - Bloom Lab @jbloom_lab

https://t.co/C90cEovQeu
Update 35 - Finland (double vaccinated + booster)

A man in the COVID ward of Landspítali with the omicron variant of the coronavirus is fully vaccinated and has received a booster dose.

https://t.co/gJQ3zvH8l1

@THAILANDMEDICA1 puts the boot in again

https://t.co/sXwrW9RBXR
Update 36 - First of many preprints on Omicron

A bleak picture? (Posted Yesterday)

Increased risk of SARS-CoV-2 reinfection associated with emergence of the Omicron variant in South Africa

https://t.co/w3jZjMVs0h
Update 37 - Omicron Origins by @WmHaseltine

Discusses 3 theories:

1. immunocompromised patient
2. Reverse Zoonosis
3. Molnupiravir-induced

https://t.co/FQp8kjo0NF
Update 38 - Fishing for Silent Omicron Mutations

"To produce those 25 selected mutations, evolution would also have produced ~50 silent ones which would persist, since they are not selected against"

But did not happen, says @tony_vandongen

https://t.co/ts5S1k9t4V
Update 39 - it gets worse, says @tony_vandongen

"The large concentration of silent mutations would have to occur anywhere in the 30k genome sequence"

But there only 7 silent mutations in total (instead of the expected 300)

Whoever designed this failed to make it look natural.
Update 40 - Explosive Thread by @VBruttel

So to sum this up:

SARS2 Omicron genome looks like it was "separated/frozen" between June 2020 and late summer 2021 -

This has never before been seen in nature, only in lab leaked pandemics

https://t.co/zwa0I9ZRBS
Update 41 - Targeted Manipulation

"only logical explanation is targeted manipulation"

https://t.co/IYejXk7lNn
Update 42 - Risky Research in Durban BSL3

https://t.co/9nJG2geEPJ
Update 43 - Omicron first detected in Durban?

https://t.co/dvbOpLmbfV
Update 44 - Frozen in Time (Further Evidence)

https://t.co/2BjK8CqD1L
Update 45 - The Durban Paper

Affiliations listed

https://t.co/Dl5FqjnQoz

Full paper: Published: 29 March 2021

Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma

https://t.co/FwaFzw5ZCp
Update 47 - Inconvenient Truths?

Rambaut @arambaut shuts down the discussion

https://t.co/uqyDE75L11

h/t @ydeigin
Update 48 - Updated Omicron Mutation Graphic

(Animals) By robert Garry

"This version makes corrects mutations sustained at Q493 and Q498 in humans (Omicron) and mice plus adds a few mink mutations."

https://t.co/UiuFb2U1qk
Update 49 - Spike mutations & Epitope Effects

Report on Omicron Spike mutations on epitopes and immunological/epidemiological/kinetics effects from literature

https://t.co/SFJWS2xzgU
Update 50 - Monkey Cells

"in an otherwise deserted lab. Cele & de Oliviera chanced their luck on using human saline to infect monkey cells, which until then had proved unresponsive to weeks of experimentation. The outcome was best Christmas gift ever"

https://t.co/thvhlcvy5M
Update 51 - Sandile Cele

KZN scientist finds new way of growing new Covid-19 variant in groundbreaking research

https://t.co/x5sZMlLBM9
Update 52 - BSL3 Lab Durban via @WhereIsYanLing

https://t.co/fpeh97T4vj
Update 53 - Interview with Sandile Cele

The Scientist Working Towards a COVID-19 Breakthrough

https://t.co/FMNvAxin23
Update 54 - Compare Dates

Image A

Startling new variant raises urgent questions (long new branch)

https://t.co/7lQTJvchji

Image B (Durban Paper) noted by @VBruttel

https://t.co/5BSOzdo3FQ

Experiments using plasma from donors with 1st wave variant B.1.351 (501Y.V2 VOC)
Update 55 - Suart Neil's Opinión

I don't usually RT Threads by @stuartjdneil but will make an exception this time as his thread presents some quite valid counter arguments against certain recent leaking suggestions,

https://t.co/gbaOfeaYG3
Update 56 - Durban Cases?

The two Durban cases likely travelled through Gauteng

Gauteng cases earlier than Durban

https://t.co/PvWHzxkzGa
Update 57 - Omicron Battered Kids?

Mainly unvaccinated for obvious reasons of course

https://t.co/mHhr8m5s2C
Update 58 - Kids, Good, Bad and Ugly

Most cases are incidentally diagnosed SARS-CoV2
https://t.co/MNMtgAZZZq

SARS-CoV2 found in admission screen
less Covid-19 pneumonia
https://t.co/QJq4AMqwja

Hospitals not made to handle mass paediatric casualties
https://t.co/sr4MuoCzsD
Update 59 Strange Mutation Ratios @P_J_Buckhaults

Non Synonymous Versus Synonymous mutations

33:1...!

https://t.co/xq1hcOlYyH

https://t.co/HYMoBxpD8s
Update 60 - Explained by Recombination?

https://t.co/J8AfX1HI9O

Missing intermediates explained?

https://t.co/s8q5eYxoGr
Update 61 -Recombination with other Coronaviruses?

Omicron variant of SARS-CoV-2 harbors a unique insertion mutation of putative viral or human genomic origin

https://t.co/vHgkmMVfLs

Same genetic sequence appears in HCoV-229E and in the human immunodeficiency virus (HIV)
Update 62 - Deja Vu

B.1.1.7 variant first detected in UK had 12 + mutations that appeared suddenly. Recombination may merge mutations from different variants that arose spontaneously within same person over time or that co-infected someone simultaneously

https://t.co/AEakq2GMT9
Update 63 - The Man from Boston - Deja Vu

Extraordinary Patient Offers Surprising Clues To Origins Of Coronavirus Variants (Feb 2021)

https://t.co/juanmyH8JE

Paper:

Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host

https://t.co/9VgREsLzxY
Update 64 - The Boston Spike Protein Mutations

What One 'Extremely Unusual' COVID-19 Case Tells Us About New Variants

https://t.co/M7yop2xmxW
Update 65 - Related Durban Paper (2)

Advanced HIV drives SARS-CoV-2 evolution?

Divergence of delta and beta variants and SARS-CoV-2 evolved in prolonged infection into distinct serological phenotypes

https://t.co/ZqwuZkaqvB
Update 66 - @EthicalSkeptic Omicron Opinión

Although I disagree with his theory, he has certainly done a great deal of background research

https://t.co/owqYx9qido
Update 67 - Super Spreading Omicron Christmas?

Party in UK where 14 of 18 guests tested positive for the new variant despite everyone being double jabbed & some with booster, all guests had taken a lateral flow test 24 hours beforehand that was negative!

https://t.co/C23vh1w5ek
Update 68 - Similar Event in Norway

https://t.co/uzXj5M9drC

and

https://t.co/YoCsE6luM8

it seems all were double vaccinated and all mild cases of illness.....so far.
Update 69 - A herd of virologists at work

Selection analysis identifies significant mutational changes in Omicron likely to influence both antibody neutralization & Spike function

Part 1
https://t.co/AvIMY7TwBe

Part 2
https://t.co/8GVcVYBu2Z

Spoiler: They are confused
Update 70 - The above paper tries hard to explain

"the extensive time period of undetected replication"

1. surveillance failure hypothesis
2. chronic infection hypothesis
3. reverse-zoonosis hypothesis
4. Combination of above

An analysis by @sergeilkp
https://t.co/kEnRmFTDhR
Update 71 "escape calculator" thread by @jbloom_lab

https://t.co/EOTzBTAK5P

archived:

https://t.co/zRBjc1LDe8
Update 72 - A sister lineage to Omicron ;)

"Nothing to worry about" says @theosanderson

https://t.co/VCiJJOtL1O
Update 73 -The contrarian point of view of @daoyu15

"VSV based directed evolution explains this almost flawlessly"

https://t.co/LYCYQ5VRyX
Update 74 - A quite tedious paper on Omicron

(one of the many to come)

Genome Characterization and Potential Risk Assessment of the Novel SARS-CoV-2 Variant Omicron (B.1.1.529)

https://t.co/FKLm1iORi0
Update 75 - Twitter as usual way ahead of academia

Scroll up from last tweet in discussion on the possibility of Omicron emerging via an HIV patient

https://t.co/bVFqm0RQno

with contributions from:

@daoyu15
@roadjull
@VBruttel
@TonyBurnetti
@pathogenetics
@P_J_Buckhaults
Update 76 - Opinion of Dr Fareed Abdullah

Discussion | SAMA: Tshwane epicentre of Omicron

https://t.co/VR2PZXtnTi
Update 77 - CEZPD scrubbing web pages a la WIV?

1. OK

Introduction to the Centre for Emerging Zoonotic and Parasitic Diseases (CEZPD) in Johannesburg (BSL3 and 4)

https://t.co/mkalJm3tpX

2. Scrubbed?

https://t.co/uR49CDWpz8

Can @nicd_sa explain?
Update 78 - A more innocent explanation

Maybe CEZPD has a virus?

https://t.co/tIAB2K2Dvg
Update 79 - Morons!

Thailand medical news loses its patience..

https://t.co/vTa0uvKaC9
Update 80 - The Arrival of Omicron

via @Onorpik
Update 81 - Omicron Cartoons (1)

Sources:

1 https://t.co/Yn6TIU5S6H
2 https://t.co/KvOA52WX5m
3 https://t.co/SwVAEMmv12
4 https://t.co/JsfuSp4ot8
Update 82 - Omicron cartoons (2)

5 https://t.co/IsIheuVazt
6
https://t.co/H8PfMwq47E
7
https://t.co/lGc3Gf3NFo

8 https://t.co/Dv4N0JXUgL
Update 83 - Omicron cartoons (3)

9
https://t.co/yuNgyImfQC

10
https://t.co/yIKflZ6pul

11 https://t.co/YM8ITI6GQ7

12
https://t.co/UGFy9mUobm
Update 84 - Omicron now avoiding detection

How dare you try to detect me, says Omicron on a trip to Australia (Queensland).

1. https://t.co/XG7gSaxPo6

2. https://t.co/wbkDFiQWrG

3. https://t.co/xokuQXHw45
Update 85 - Two Lineages within Omicron

@BallouxFrancois says:

There are two lineages within Omicron, BA.1 and BA.2, that are quite differentiated genetically. The two lineages may behave differently.
Update 86 - Welcome Omicron's Sister!

Proposal to split B.1.1.529 to incorporate a newly characterised sibling lineage

List of mutations found in Omicron's sister

https://t.co/LdHOHR931q

and image

https://t.co/GZDVeLYrTn
Update 87 - @arambaut busy deleting comments & closing discussions

"There are B.1.1.529 lineages that do not have the N440K & K417N mutation (336 GISAID entries) & form a separate clade when analysed with other sequences that do contain these mutations"

https://t.co/7q4OVyjmF1
Update 88 - Transmission to a second person?

"Either an intermediate that didn't acquire all defining mutations or it is consensus of a mixture of 2 lineages"

"If chronic infection hypothesis is true, no reason to believe patient zero would only have transmitted to one other"
Update 89 - One BIG uncertainty

Omicron’s less severe cases prompt cautious optimism in South Africa

"However, potential for Omicron to result in less severe symptoms may be more a consequence of immunity than the virus evolving to become less virulent"

https://t.co/1n02xgs5ZH
Update 90 - Thread by @jburnmurdoch

(explaining aspects of FT article linked in last tweet)

https://t.co/hGQA5RCfeU
Update 91 - AB Neutralisation of Omicron Variant

The Good (Pfizer Spin)
https://t.co/vIgMF0Of9A

The Bad:
Average loss of neutralization potency was lower than feared
https://t.co/HRVHRqBj6m

The Ugly:
Up to 37 times reduction in Delta vs. Omicron
https://t.co/ZVqXwItBwP
Update 92 - The Ugly (reasons)

monoclonal AKs imdevimab and casirivimab are - as expected - ineffective with Omicron

experiments were carried out with a virus isolate (infectious virus), not with pseudoviruses.

Question about different results

https://t.co/EXZymWYFGb
Update 93 - The "Ugly" Paper @CiesekSandra

Reduced Neutralization of SARS-CoV-2 Omicron Variant by Vaccine Sera and monoclonal antibodies

https://t.co/3QYSjyp3Az
Update 94 - The opinion of @BallouxFrancois

on the antibody neutralisation results for Omicron

https://t.co/95iYlyoJgg
Update 95 - Big One straight from the Horse's Mouth

@Sandile_Cele22 @Tuliodna So, pay attention!

SARS-CoV-2 evolved during advanced HIV disease immunosuppression & has Beta-like escape of vaccine & Delta infection elicited immunity

https://t.co/1yDnZ7JNtz

h/t @mouth_madness
Update 96 -Shape shifting Omicron?

https://t.co/enR1ucg5Hd
Update 97 - Omicron Lab Leak Hypothesis (Thread)

https://t.co/WV7IBrzk80
Update 98 Surely some revelation is at hand?

Surely the Omicron is at hand.

https://t.co/uLFIIA8K3D
Update 99 - Lab Leak 2.0 (worth a read)

Summarised many anomalies discovered to date

https://t.co/654LCTQTml

via @capitolsheila

More from Billy Bostickson 🏴👁&👁 🆓

1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!
2 papers:
Human–viral molecular mimicry
https://t.co/irfH0Zgrve
Molecular Mimicry
https://t.co/yLQoUtfS6s

2. Must Read! Confirmation with supporting evidence via @flavinkins
https://t.co/NEf9HK6ReB
"ONLY place where this thing could emerge, naturally or Artificially, is by passage in HUMANIZED MICE"

3. Springer Article


4. Takeaway most significant quotes from Springer Article, burn this into your brain:
"Such a peptide commonality is unexpected and highly improbable from a mathematical point of view"


5. One image to explain it all!
1/X Bellagio Rockefeller Initiative (Global Virome Project)
Another look at some key people in the GVP & their media statements since January 2020 about "natural origin" and impossibility of a "lab leak"
Full List of 18 scientists in photograph is here:
https://t.co/yHoAjwQjI8


2/X
We have already looked closely at Dennis Carroll, Peter Daszak, George Gao, W. Ian Lipkin & seen their public statements supporting "natural origin" & hysterical attacks on "lab leak" theories.
This thread focuses on:
Michael Kurilla
Jonna Mazet
Edward Rubin (Metabiota)

3/X
If we look at the leadership team of GVP, you will see some familiar faces:
https://t.co/WdT8sNnfmy
Most familiar is probably Peter Daszak, the wealthy Treasurer, also with the key role of Secretary.
Note: USAID PREDICT Project - EcoHealthAlliance


4/X
The "Chair" is Dr. Dennis Carroll
We will have a look at his media statements on the coronavirus pandemic by inputting his name in Twitter search box (very easy!)
Note: Previously was Director of USAID Emerging Pandemic Threats Program


5/X Dennis Carroll's video media statements (1):
CNN
(note Qinghai Thangka positioned in background which Daszak also shows off in his videos obtained during EcoHealth virus hunt with
1. Thread: RaTG13 Real or Fake?
A Norwegian Scientist @Vehuardo recently claimed RaTG13 is an "authentic virus"
https://t.co/tAXMNTwdhA
This failed to take into account the work of our DRASTIC colleagues & other published analyses.
This thread is a polite attempt to educate.

2.
https://t.co/tw606vgHwp
which says RaTG13 doesn't make sense on how it was sequenced, or how the data got so messed up in the lab as to include copy paste mistakes, bat dna, pangolin dna, rice dna, mice dna, & nobody should use it to form conclusions until it's properly vetted

2 (cont)
"sequence is incomplete & provided segment doesn't function. The identified markers suggest partial match basis & actual virus itself as described by the sequence can't functionally exist due to incoherent structures that appear to be the result of sample contamination"


3. RaTG13 integrity is further attacked here:
The Validity of critical pieces of evidence for the natural origin of SARS-CoV-2 is Dubious, and needed to be

4. and here:
Major Concerns on the Identification of Bat Coronavirus Strain RaTG13 and Quality of Related Nature
1. A Tangled Web - Ecohealth, Chmura, WIV
I have been going back to Chmura's Thesis work after reading the confessions of bat abuse in Quammen's spillover to look for more clues as to what was going on over the last two decades with bat research in

2. A previously aborted


3. The Chmura Story is in Chapter 38 of Quammen's Spillover
https://t.co/mFomOog94F


4. Some details are also mentioned here
via @gdemaneuf

5. Amusing

More from All

(थ्रेड)

वर्ण व्यवस्था जन्मना या कर्मणा ?

इस थ्रेड का लक्ष्य वर्णाश्रम व्यवस्थाके संबंध मे किए गए अनर्गल प्रलापों का निराकरण करने तथा धार्मिक एवं सुधि जनों के हृदय मे विद्यमान भ्रांतियों को दूर करने का है।

नोट – पाठको से प्रार्थना है की वे अपने हृदय से सभी पूर्वाग्रहों को


निकाल कर प्रारंभ से ले कर अंत तक इस थ्रेड को पढ़ें यदि पढ़ने के उपरांत कोई शंका हुई तो उसका समाधान समय मिलने पर शास्त्रीय प्रमाणों के द्वारा किया जाएगा।

आज हम इस थ्रेड मे ४ प्रश्नों पर विचार करेंगे यथा –

१.वर्ण व्यवस्था जन्मना होती है या कर्मणा ? शास्त्रीय पक्ष क्या है ?

२.क्या वर्ण और जाती अलग अलग है ?
३.क्या वर्ण एवं जातियों का प्रभेद समाप्त कर सबका हिन्दू हो जाना ठीक है ?
४.क्या हिंदुओं का पतन वर्ण व्यवस्था के कारण हुआ है या हो रहा है ?

इन सभी प्रश्नों का निराकरण शास्त्रीय पक्षों एवं तर्कों के आधार पर किया जाएगा जिन महानुभावो को कष्ट या

आपत्ति हो वो गाल बजाने अर्थात कुतर्क करने की अपेक्षा शास्त्रीय पक्ष के द्वारा पूर्वपक्ष करने मे स्वतंत्र हैं उसका समुचित उत्तर समय मिलने पर दिया जाएगा । अमर्यादित टिप्पणी करने पर सीधा ब्लॉक किये जाएंगे अतः सावधान रहें -

अब हम अपने विषय पर आते हैं, हमारा पहला प्रश्न ये है की -

१. वर्ण व्यवस्था जन्मना होती है या कर्मणा ? शास्त्रीय पक्ष क्या है ?

उत्तर - आए दिन हम “वर्णव्यवस्था जन्मना या कर्मणा” इस चर्चा को देखते रहते हैं इस चर्चा मे पूर्वाग्रह से ग्रसित कुछ तथाकथित बुद्धिजीवी पुराणेतिहास, स्मृति, गीता आदि आर्ष ग्रंथों के किसी एक श्लोक अथवा वचन को उठा

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