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For all of those folks blaming states for the failures in vaccine distribution...


Folks like @JamesSurowiecki spent time blaming states and municipal governments for not doling out the vaccines quickly enough. Yet forgot that the federal government is in charge of vaccine distribution - and didn't buy enough vaccines to start.


By the way: We knew that the feds, under the Trump regime, would mess this up. It was reported back in December that the Trump regime didn't buy enough of the Pfizer vaccine, even after the pharma offered to supply more.

This is unsurprising, and yet, still tragedy.


But none of the blame laid at the feet of states and municipalities is shocking, either. Folks have been blaming school systems for not having the resources to reopen school buildings - and for not being able to reopen in the midst of high community spread.
True story. My first visit to a grocery store in the US 15 years ago, I asked an employee where to find "capsicum". He sent me to the juice aisle. I asked another employee. Also juice aisle. Third person I asked came with me and patiently pointed out the Capri Sun shelf. 😂😂😂


Reminiscing about my grocery store visits when new to the US. Only kind of shopping I do recreationally. First couple of weeks, I spent hours just hitting different grocery shops and checking out all the foods and randomly buying some that I'd read about or seen on TV.

One of my first instinctive purchases was a turkey drumstick. So huge! Reminded me of those big joints of meat eaten by Jughead or Obelix or Flintstones. I bought it and tandoorified it at home right away in my oven debut. I had never seen an oven before that. Was a bit scared.

I remember the time I came home with a can of spam and my roommate (who was in his 5th year in the US) was like why spam? It sucks! I said yeah, but I have to taste the meat so bad that junk mail is called that. I gamely finished the can. Never bought it again. 😂😂

I visited 1st in 05 and moved in 06 so it was the cable TV, blogs, torrents age. Not exactly a time when US culture was largely unknown to us. I knew it's okra not ladyfinger, eggplant not brinjal, 1 oz is ~ 30g, 1 lb ~ half kg etc. But some blind spots remained. Some for years.
Lots of tweets about this today!
Let's see what we can see in the focal S:E484 build!

Phylogenetics (what I do - making 'family trees' from virus genetics) can be very informative to see how different variants are spreading, and how cases

There are two variants circulating predominantly in Brazil:
- 20B/S.484K seems to be older & more widespread. It has (among others) a mutation at position 484
- 20J/501Y.V3 is smaller & detected recently. It has mutations at 501 *and* 484.

2/10

https://t.co/Cw5u2kuATa


The variant predominantly in the UK (501Y.V1 / B.1.1.7) and the variant predominantly in South Africa (501Y.V2) also both have 501. 501Y.V2 *also* has the 484K mutation.

Why are there concerns about these mutations? You can read more at https://t.co/wVE7ubYBoy!

3/10


The view below is from an analysis focusing on sequences with a mutation at 484. It shows all the samples in the 2 variants (20B/S.484K & 20J/501Y.V3) & how they're related. More closely related = closer together (very, very roughly).

4/10


We can colour these samples by region to see where they're from. As we expect - most are in Brazil! A few are in Argentina (also red).

5/10

https://t.co/Cw5u2kuATa