https://t.co/WzW1jmgaNG
https://t.co/WzW1jmgaNG
https://t.co/J0vmyGogVX
https://t.co/WrQBiQ9HPN
https://t.co/kwWYtEblfP
Remember that the reason you\u2019re wearing a diaper on yourself face and locked up at hone is because of fear of asymptomatic spread. Turns out - that\u2019s not a thing and we\u2019ve known that since January. pic.twitter.com/ebawhmG0z3
— Justin Hart (@justin_hart) December 26, 2020
https://t.co/3SjPqUmRZ9
PCR tests don't diagnose Covid, which is a disease. They detect SARS-CoV-2, with varying reliability. It is incorrect to describe a +ve test as a "case" in the absence of a clear clinical picture of Covid, the disease. Governments reporting cases on tests alone are misinforming.
— Nick Hudson \U0001f642 (@NickHudsonCT) December 19, 2020
https://t.co/G8fCxgzA5b
https://t.co/bhFGE41I8v

https://t.co/AtCl8q6cFG
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Are more people waking up? pic.twitter.com/pbwBck8tPc
— \U0001f334 Josh Lekach \U0001f334 (@JoshLekach) December 27, 2020
More from World
Watch the entire discussion if you have the time to do so. But if not, please make sure to watch Edhem Eldem summarizing ~150 years of democracy in Turkey in 6 minutes (starting on 57'). And if you can't watch it, fear not; I've transcribed it for you (as public service). Thread:
"Let me start by saying that I am a historian, I see dead people. But more seriously, I am constantly torn between the temptation to see patterns developing over time, and the fear of hasty generalizations and anachronistic comparisons. 1/n
"Nevertheless, the present situation forces me to explore the possible historical dimensions of the problem we're facing today. 2/n
"(...)I intend to go further back in time and widen the angle in order to focus on the confusion I believe exists between the notions of 'state', 'government', and 'public institutions' in Turkey. 3/n
"In the summer of 1876, that's a historical quote, as Midhat Pasa was trying to draft a constitution, Edhem Pasa wrote to Saffet Pasa, and I quote in Turkish, 'Bize Konstitusyon degil enstitusyon lazim' ('It is not a constitution we need but institutions'). 4/n
https://t.co/1GtPJaxi1H - Ka\xe7\u0131rmay\u0131n bu muhte\u015fem Bo\u011fazi\xe7i hocalar\u0131 ge\xe7idini !
— dilek cinar (@dlkcinar) February 16, 2021
"Let me start by saying that I am a historian, I see dead people. But more seriously, I am constantly torn between the temptation to see patterns developing over time, and the fear of hasty generalizations and anachronistic comparisons. 1/n
"Nevertheless, the present situation forces me to explore the possible historical dimensions of the problem we're facing today. 2/n
"(...)I intend to go further back in time and widen the angle in order to focus on the confusion I believe exists between the notions of 'state', 'government', and 'public institutions' in Turkey. 3/n
"In the summer of 1876, that's a historical quote, as Midhat Pasa was trying to draft a constitution, Edhem Pasa wrote to Saffet Pasa, and I quote in Turkish, 'Bize Konstitusyon degil enstitusyon lazim' ('It is not a constitution we need but institutions'). 4/n
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK

In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa

Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
