A man's greatest gift to a woman is her femininity, or perhaps more accurately stated - the safety and freedom to embrace her femininity, to connect with the purity and innocence of her inner child, warm and loving with all the grace, charm and happiness that entails.

1/People I know on the Right tend to be obsessed with the idea of "crimethink", taboos, and the (supposedly) oppressive, omnipresent enforcement of liberal cultural norms.

Why?

My new theory: A lot of it is guilt.

2/It's true that in some circles - the media, universities, many big corporations - liberal norms *are* enforced to some degree, and the enforcement has probably gotten stronger in recent years.

But I don't think this explains all of the Right's obsession.

3/The stereotype is that people on the Right tend to be more threat-sensitive. That would help explain the perception that liberal norm-enforcers are lurking everywhere, ready to pounce and anathematize anyone who makes a misstep.

But I don't think that's all of it either.

4/And of course, it's always fun - whether you're on the Right or the Left, or playing a video game, or whatever - to style yourself as the brave iconoclastic rebel fighting against the oppressive forces of blah blah blah.

But I don't think this is all of it, either.

5/The reason I think it's more than these things is that even *in private*, people on the Right express their "crimethink" ideas very gingerly and hesitantly.

I get the sense that they're not just afraid of external censure, but have also internalized liberal norms.

@danielashby @AdamWJT @Greens4HS2 @TheGreenParty @GarethDennis @XRebellionUK @Hs2RebelRebel @HS2ltd I'll bite. Let's try to keep it factual. There's a reasonable basis to some aspects of this question, that it might be possible to agree on. Then there are other, more variable, elements which depend on external factors such as transport and energy policy. /1

@AdamWJT @Greens4HS2 @TheGreenParty @GarethDennis @XRebellionUK @Hs2RebelRebel @HS2ltd First up, we know reasonably well how much energy it takes to propel a high-speed train along the HS2 route. We can translate that into effective CO2 generated by making some assumptions about how green the electricity grid is. /2

@AdamWJT @Greens4HS2 @TheGreenParty @GarethDennis @XRebellionUK @Hs2RebelRebel @HS2ltd Secondly, we have a reasonable grasp of how much CO2 is going to be generated by building HS2 - there are standard methods of working this out, based on the amount of steel, concrete, earthmoving, machine-fuelling etc required. /3

@AdamWJT @Greens4HS2 @TheGreenParty @GarethDennis @XRebellionUK @Hs2RebelRebel @HS2ltd Thirdly, we can estimate how much CO2 is generated by cutting down trees, and how much is captured by planting new trees. We can also estimate how much CO2 is needed to keep the railway running and generated by maintaining the track /4

@AdamWJT @Greens4HS2 @TheGreenParty @GarethDennis @XRebellionUK @Hs2RebelRebel @HS2ltd We know how much CO2 is saved by moving goods by freight train on the lines freed up by moving the express trains on to HS2, rather than by truck. /5

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10