BC SCIENCE
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Light travels at about 1 foot per nanosecond.

 Hold your hand up 12 inches from your face: you’re seeing your hand as it was a nanosecond ago. Everything you look at is, to one degree or another, in the past. The farther away in space, the more ancient in time.
You can’t see the Sun as it is now, but you can see it as it was about 8 minutes ago. You can’t see Alpha Centauri now, but you can see it 4.4 years ago. You can see the Andromeda Galaxy as it was 2.5 million years in the past. And so on.
With powerful telescopes, we can see galaxies whose light has been traveling to us for more than 13 billion years. We see them shining in a universe that’s still young, where gravity has just begun to pull matter together into stars and galaxies.
We can see something even more distant, and more ancient, than the first galaxies. If we peer out far enough, in between the galaxies, we can see parts of the Universe that are so far away, it has taken the light from that distance almost the entire age of the cosmos to reach us.
When we look at the most distant parts of the cosmos, in every direction, we see parts of the Universe that are so far in the past, they’re still in the final stages of the Big Bang. So far away, so far back, the space is filled with a dense, roiling plasma, the fire of creation.
We are not the center of the Universe. But we are the center of our own perception as light reaches us from afar; we lie embedded in nesting-doll layers of cosmic time. Each concentric sphere is an era. We can see the structure of matter changing, like geological strata around us
The most distant layer of time that we can see is the light that has been traveling since the moment the primordial fire began to cool. The cosmic microwave background surrounds us at every edge of our vision. We are embedded in shells of cosmic time, and the final one is fire.

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Marit Kolby Zin\xf6cker
Marit Kolby Zinöcker...
@zinocker
Did we get dietary saturated fats all wrong? The #HADLmodel provides a new understanding and an opportunity to get it right. THREAD👇👇👇
@simondankel @kariannesve

Increased dietary saturated fatty acids lead to increased cholesterol in lipoproteins, but we don’t know why. Enter the #HADLmodel, which explains changes in lipoprotein cholesterol as adaptive homeostatic adjustments that ensure optimal cell membrane fluidity and cell function.

We propose that circulating lipoproteins enable appropriate redistribution of cholesterol molecules between specific cells and tissues, to accomodate changes in dietary fatty acid supply, due to our omnivore nature and variable intake of fatty acids. #HADLmodel

Our #HADLmodel implies that circulating levels of LDL change for protective, not for pathological reasons; an SFA-induced raise in LDL cholesterol in healthy individuals is a normal response, while a lack of this needed response may reflect a deeper pathology in lipid handling.

Circulating lipoproteins may change for pathological reasons, when regulatory mechanisms become disrupted by pathogenic processes related e.g. to inflammatory processes. Diverging lipoprotein responses in healthy versus metabolically unhealthy individuals support this view.
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Thomas A. Fine \U0001f1fa\U0001f1f8
Thomas A. Fine 🇺🇸...
@thomasafine
Let's talk about Avi Loeb and his theory about alien

First, I should disclose that I work at the fame research facility as Dr. Loeb, though I work in a different department and to my recollection we've never met.

He's a scientist; I'm in computer support.

With that out of the way...
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In particular he compares his theory on alien visitation with the multiverse theory.

Which of these is more deserving of ridicule?

Science is fundamentally a structure for forming hypotheses and then (critically) testing these hypotheses to see if they should be kept, rejected, or modified.
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Smit Patel
Smit Patel
@snazzysmit
Super excited to share my very first lead-author paper in @ScienceAdvances

Supported by @HIRN_CC @NIDDKgov @UFBME @UFWertheim @ufdiabetes @UMCoEDean
Lead by @Cherie_Stabler & @ashu83

link: https://t.co/FbqVWQ0n5p

This is a thread 👇

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⚪️A Lab-on-a-Chip platform for organoids w/ wide capabilities: long-term culture | controlled & dynamic perifusion | in situ spatio-temporal imaging | serial cell assessment | ease of sample retrieval


⚪️Continuous fluidic flow increased local oxygen supply to islets in hydrogels & reduced cellular hypoxia
⚪️Flow increased cellular viability & reduced apoptosis & cell death

⚪️Human islets in hydrogels were highly functional during the 10 day in situ culture in our chips, while islet function was rapidly lost under static conditions
⚪️Glucolipotoxicity study showed a treatment window as small as 2.5 hours can elevate cell death

What are organoids? – A miniaturized version of an organ that imitate an aspect of human interface. They are commonly developed from stem cells in a lab. Human body also produces organoids naturally particularly within the pancreas.
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Matthew Salganik
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Announcing the 2021 Summer Institutes in Computational Social Science. #SICSS is for grad students, post-docs & beginning faculty. Free for participants. @chris_bail and I are happy to tell you about all 20 locations. https://t.co/wolhtZIMc5 [thread]


SICSS brings together social scientists & data scientists interested in computational social science for 1-2 week events with intensive study & collaborative research.

Topics covered include automated text analysis, web scraping, non-probability sampling, digital experiments, ethics & much more.

All education materials created for SICSS are available open-source so that people who are unable to participate can still learn. You can also use them in your teaching. Here are materials from previous years:

Because of COVID, all SICSS locations will be online only in 2021.
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Asbj\xf8rn St\xf8ylen
Asbjørn Støylen
@strain_rate
1/ #LBBB generates often a classical pattern on #EchoFirst. The pattern is very distinctive in Tissue Doppler of the septum.


The classical pattern arises from the time lapse of the activation and relaxation of the two walls, creating a pattern of interaction due to a sequence temporal imbalances of the tension between the two walls.


2/ As the septum is activated first, it contracts (shortening - septal flash) without activation of the lateral wall, which stretches. This generates slower pressure build up than a normal IVC, which then is prolonged.


3/ During ejection, the LV volume decreases, so both walls shorten. Tension, however, declines first in the septum, as this was activated first. This leads to a tension imbalance, so the lateral wall continues to shorten, the more relaxed septum stretches.


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Anu Satheesh \U0001f1ee\U0001f1f3
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Cherthala Karthyayani Temple Prathishta was done by Vilwamangalam Swamy. Chertala Pooram is very famous. Devi is Mangalya Dayini here removes obstacles relating to marriages. Sthala Puranam says that, once 👇


Vilwamangalam Swamiyar was passing this area after Prathista of Padmananbhaswamy Temple, he felt Devi chaitanyam and recognized as Karthyayani Devi. But Devi seeing Vilwamangalam went inside the pond. Swamy searched for Devi continously for 6 days and on 7th day Vilwamangalam


got hold of Devi's hair. Thus only Devi's head is Prathishta here. Devotees do Kozhi parathal ( offering cock) here as an offering to Karthyayani Devi.

Karthyayaniamme Sharanam
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Devi is worshipped in the temple as Thirumalai Kaali amman

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Bhattar conveyed the news to the Pandalam Raja and they went to find out the vigraham. Surprisingly ants showed the way to find the Vigraham. Thus Murugan vigraham was found and Prathista was done here. There is a lake with pure water on the top of the hill


which is said to be created by Agasthiyar. It is believed that kannaki of
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Om Muruga
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Vibhu Vashisth
Vibhu Vashisth
@VIBHU_Tweet
Did you know?

When Saudi Arabia's King visited India in 1955, PM Nehru ordered all the Hindu Temples and Idols of Hindu Deities that came in Saudi King's way to be covered up.
Our temples are the architectural marvels in their own league.


Each of our temples tells the story of our rich history and cultural heritage. Was Nehru that ashamed of his own nation's heritage that he had to cover them up or there was some other reason? The answer would be best known to him only.

PM Nehru invited the then Saudi King Saud bin Abdul Aziz to India who accepted the invitation and planned a 17 day long official visit to India in 1955. Saudi King had brought a large delegation with him and he had to visit various Indian cities like Mumbai, Hyderabad, Agra,


Aligarh, Shimla, Mysore and Varanasi. However, when Saudi King reached Varanasi, Nehru ordered to cover all the temples and Idols with curtains that came in the way of the Royal Convoy. During his stay in Varanasi, Govt buildings were painted with the words "Kalma Tayyiba".


'Kalma Tayyiba' means 'There is not God but only Allah and Mohammed is his messenger'. In addition to it, Pooja and Aartis were also stopped at temples. I can call it the appeasement politics of the highest order and Nehru was indeed the greatest appeaser of all times.
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Billy Bostickson 🏴👁&👁 ...
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.

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(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK


In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa


Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
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