The most frustrating aspect of working in computational probability/statistics is that it's basically impossible to construct algorithms that actually return well-defined probabilistic quantities and this results in no end of chaos.

My dad’s first memory is hiding under a table 80 years ago tonight, when Nazis took his dad to Dachau on #Kristallnacht.

His parents, my Omi and Opi, always considered themselves more German than Jewish, so they didn’t think they’d get swept up in the madness.

Opi was taken to city hall with other Jews and lined up against a wall. He thought he was going to be shot.

He always remembered when they got to Dachau there were pajamas with Jewish stars waiting on their cots. Obviously not a spontaneous thing.

He was very lucky. His family got him a fake Uruguayan visa and he was out of Dachau six weeks later. “Before Christmas,” my dad recalls.

LET’S TALK ABOUT RELOCATING TO CANADA AND HOW TO APPLY FOR PERMANENT RESIDENCE (PR) IN 2021.

Are you interested in relocating to Canada and don't know where to start from? No worries, this tweet is for you.

A THREAD! 👇

I was supposed to make this post before now but I had to do extensive research and verify its authenticity before posting.

Stay with me...

One of the reoccurring topics in Nigeria today is how to ‘Japa’ (Move away) from Nigeria.

The question that comes to mind are:
> How do I go about it?
>What is the process like?
>Is there a seamless way to go about it?

First thing you must know is that from 2021 to 2023, Canada will welcome more than one million new immigrants! Yayyy!!! Good news abi??

I really do not blame anyone who decide to ‘japa’...

Do you know the benefits that accrues to one becoming a permanent resident in Canada?
Let me share them with you.

1. You can live and work anywhere in Canada. Yeah! Anywhere. Permanent Residents are not tied to a specific employer or a specific province...

SocialCops’ 10 (base 10) Engineering Commandments — the values that drive everything for the #Engineering Team #InsideSocialCops 🙌

(Thread👇) Tell us if you can relate to any of these? Do you have your own values that guide your decisions? Share them with us! ⛳

0. Coder != engineer

Coders focus just on writing code to make something work. Engineers take a much wider view, focusing on both the problem and every aspect of the solution. 🤓

1. “Import lib”

It's not wise to waste time building tools or libraries if there’s already something that does the same job! Wherever possible, extend existing libraries and contribute back to the community. 💁‍♀️

2. With great power comes greater responsibility

Every choice we make on our platform and every feature we build stands up to a responsibility — helping people make more data-driven decisions and bring about real change for millions of people. 💪

3. Fail fast and keep learning

Failing fast is about doing lots of fast iterations and learning from each, rather than getting stuck on one solution or decision. 👊

@danielashby @AdamWJT @Greens4HS2 @TheGreenParty @GarethDennis @XRebellionUK @Hs2RebelRebel @HS2ltd I'll bite. Let's try to keep it factual. There's a reasonable basis to some aspects of this question, that it might be possible to agree on. Then there are other, more variable, elements which depend on external factors such as transport and energy policy. /1

@AdamWJT @Greens4HS2 @TheGreenParty @GarethDennis @XRebellionUK @Hs2RebelRebel @HS2ltd First up, we know reasonably well how much energy it takes to propel a high-speed train along the HS2 route. We can translate that into effective CO2 generated by making some assumptions about how green the electricity grid is. /2

@AdamWJT @Greens4HS2 @TheGreenParty @GarethDennis @XRebellionUK @Hs2RebelRebel @HS2ltd Secondly, we have a reasonable grasp of how much CO2 is going to be generated by building HS2 - there are standard methods of working this out, based on the amount of steel, concrete, earthmoving, machine-fuelling etc required. /3

@AdamWJT @Greens4HS2 @TheGreenParty @GarethDennis @XRebellionUK @Hs2RebelRebel @HS2ltd Thirdly, we can estimate how much CO2 is generated by cutting down trees, and how much is captured by planting new trees. We can also estimate how much CO2 is needed to keep the railway running and generated by maintaining the track /4

@AdamWJT @Greens4HS2 @TheGreenParty @GarethDennis @XRebellionUK @Hs2RebelRebel @HS2ltd We know how much CO2 is saved by moving goods by freight train on the lines freed up by moving the express trains on to HS2, rather than by truck. /5

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10