BC SOCIETY
Saved by @jay_millerjay

AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

 In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10
...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10
...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10
...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10
...survival rate after 60 days for the standard-dox group was 0%; and 100% for the pro-dox group.

#AVCT isn't looking to improve chemotherapies by 25-30%, like most drugs in clinical trials.

Its pre CISION has the potential to improve the safety profile - and thus the... 6/10
...efficacy (via increased dosing) - by MULTIPLES. It is not an exaggeration to state that pre CISION could transform the chemo market - in fact, the overall oncology space. Survival rates could increase materially - as the mouse trials demonstrated. 7/10

https://t.co/XOEE45CBtZ
For #AVCT, it stands to reason that if the pro-dox trial is a success, then the pre CISION tech is also highly likely to work for other existing chemotherapies. @avacta has a pipeline of at least a dozen others in development.

AVCT holds the global exclusive licence over...8/10
...the pre CISION tech. It is also combining the tech with its second platform, Affimers - to create a third therapeutic platform, named TMAC.

TMAC will produce Affimer Drug Conjugates - a potentially more powerful class of oncology treatment than Antibody Drug Conjugates. 9/10
More on TMAC and AfDCs another time, but suffice to say that if they do work in man, #AVCT could become one of the most sought after oncology companies, globally.

First though, success for AVA6000 please!

Then hopefully @avacta's first TMAC drug to enter Phase I next year 10/10

More from Society

What The Trans!?
What The Trans!?
@WhatTheTrans
A thread on how absurd the UK is on transgender issues and how the UK got so transphobic

In 2015 Parliament held an inquiry looking into the state of Transgender equality. Trans people of all stripes outlined many different problems across many, many different areas.

As a result Parliament created a list of recommendations including legal recognition for non binary people, gender recognition act reform, allowing 16 year olds to change their legal gender and reform of NHS gender identity services.

The government under Theresa May ignored everything that was recommended except for Gender recognition act reform. This act came into law in 2003 and gave trans men and women (but not non-binary people) the ability to legally change their gender on their birth certificates.

The process at that time to change your birth certificate under the GRA was to make an application to a panel of cisgender people who would decide if you were sufficiently trans based on your payslips, photo ID and bank statements. You would not get the option to speak to them.

(Also this process cost £140 which is just a tax on being trans)
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Twitter Data
Twitter Data
@TwitterData
r u abbreving less rn?

Since the switch to 280 characters a year ago, we've seen an increase in people writing out full words and phrases.


All about the please and thank you.

With 280 characters, people are saying 'please' (+54%) and ‘thank you’ (+22%) more.

THANKS!!!!

💬💬💬

280 characters later, there are more ? and replies to Tweets. More room, more conversations!
SOCIETY
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el gato malo
el gato malo
@boriquagato
global health policy in 2020 has centered around NPI's (non-pharmaceutical interventions) like distancing, masks, school closures

these have been sold as a way to stop infection as though this were science.

this was never true and that fact was known and knowable.

let's look.


above is the plot of social restriction and NPI vs total death per million. there is 0 R2. this means that the variables play no role in explaining one another.

we can see this same relationship between NPI and all cause deaths.

this is devastating to the case for NPI.


clearly, correlation is not proof of causality, but a total lack of correlation IS proof that there was no material causality.

barring massive and implausible coincidence, it's essentially impossible to cause something and not correlate to it, especially 51 times.

this would seem to pose some very serious questions for those claiming that lockdowns work, those basing policy upon them, and those claiming this is the side of science.

there is no science here nor any data. this is the febrile imaginings of discredited modelers.

this has been clear and obvious from all over the world since the beginning and had been proven so clearly by may that it's hard to imagine anyone who is actually conversant with the data still believing in these responses.

everyone got the same R
SOCIETY
The Soup
The Soup
@TheSoup_India
A thread celebrating the many lady librarians of Mumbai, because very often, a woman who reads creates societies of people who read.

Seen here is Mrs Gulshan Feradoon Cooper, Head Librarian for over forty years at The People's Free Reading Room in Dhobitalao. “I am not at all strict, that’s my only drawback,” she said. (She doesn't charge a fine).


“I prefer research libraries because I don’t like novels, I like history," said Sarita Shekar Gandhi, Head Librarian at KR Cama Oriental Institute. Over her years at the library she has devoted herself to understanding the nuances of Zoroastrian studies.


Bidisha Basu co-started @leapingwindows , a library and café for comic books, graphic novels and manga. “You get people who have never read a comic before and that’s the most interesting part of the job. It’s exciting to introduce them to comics," she said.


“A librarian should not only love books, she should also love people," said Arati Desai the Head Librarian at the immaculate Nehru Centre Library in Worli. "I've even swept and swabbed my library, there's dignity in everything that you do at work," she goes on to say.
SOCIETY
Miss iCy Cold
Miss iCy Cold
@Credible_Intel
OK winger wonderland story time boys & girls.

1. Sleet stops, it's warming up, neighbor decides get out & drive, probably after seeing some truck drive down our residential road (4-wheel drive). Neighbor has new SUV push button start, 2-wheel drive, which is NOT THE SAME THING.

2. So anyway, they back out of their garage & then pull forward down their driveway. The driveway is flat, but it's also a really really long driveway that goes from the back of the house down the side of the house. This will be important later.

3. They make it down the driveway just fine, so now super confident this will go well.

They pull out on our little residential road and start driving.

Mother nature is laughing her ass off right about now.

4. I should mention the roads through our little subdivision don't have curbs or sewers. We're basically out in the country so they just slope roads so the run-off goes into a ditch at the side of the road.

5. So anyways, their SUV starts to slightly fishtail. They haven't gone far at this point. So, they stop, and the SUV, although stopped, just ever so slowly slides to the side of the road and ends up half way in the ditch & almost tipped over.
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KANIPAKAM VINAYAKA, CHITOOR (AP)
#bharatmandir

Kani means wetland and Pakam means flow of water into wetland.
Kanipakam Vinayaka is swayambhu (self-manifested). The murti is in a well which is always full of water.


Once, there were three brothers. Each one had a handicap- Dumb, Deaf and Blind. They had a small piece of land for livelihood. For their field, they drew water from a well. One day, they found that the well had dried up so one of them started digging in the well.


His tool hit something and blood oozed out. They found a swayambhu murti of Ganesha here.
Villagers started offering coconut water which overflew into a channel. Hence the name Kanipakam.


The murti is still growing in size. At present, we see the knees and the abdomen only. The Kavacham (Armour) offered to Vinayaka 50 years ago doesn’t fit today.
Vinayaka is believed to be the upholder of truth. So people come here and swear before him to prove their innocence.
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Jaya_Upadhyaya
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@Jayalko1
KANAKA DURGAMMA, VIJAYWADA (AP)
#bharatmandir

Ma Kanakadurgeswari is the supreme Goddess of Andhra Pradesh, seated atop the Indrakilaparvatha at Vijayawada.
This area is called Bezawada as Shiva made a bejjam (hole) in the rocks so that Krishna river could flow freely.


Once, a Rishi Indra Keela prayed to Devi and asked her to reside on his head forever. Devi told him to wait in the form of a mountain in the holy plains of River Krishna.
Later, when Devi killed all demons, she settled on Keeladri as Mahishasura Mardini and fulfilled his wish.


In this place, Arjuna performed penance and fought with Shiva, who had appeared in the guise of Kiratha to win Pasupathastra, the most powerful weapon. So this place is also called phalguna theertha and Vijaywada on account of Arjun’s victory.


Adi Sankaracharya visited this shrine and worshipped the Devi. He installed SRICHAKRAM at the feet of Sri Kanaka Durga.

Adjacent to the Kanakadurga shrine is the shrine of the divine consort-Sri Malleswara Swamy on the Indrakeeladri.
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Buzz Chronicles
Buzz Chronicles
@buzz_chronicles
@SaveToBookmarks Namaste! You can find it here. Original tweet by @AchuthArora: "@OllieEmberson @buzz_chronicles @rattibha @SaveToBookmarks save as Workouts". Thanks! ✌

Hi! Pleasure is mine. Original tweet by @SaveToBookmarks: "@AchuthArora @OllieEmberson @buzz_chronicles @rattibha Cool mate!

I saved this ...". See You soon! 👌
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Emperor\U0001f451
Emperor👑
@EmperorBTC
Technical Analysis Masterclass- Part 2

'Entering the trade'

Entering a trade without ascertaining a certain things is gambling.

In this masterclass we will learn the pre-requisites to enter a trade.

DON'T ENTER A TRADE WITHOUT DETERMINNG THE FOLLOWING.

Please share.

We understand what reward to risk (popularly called risk to reward) is.
It will be denoted by R:R.

We will also try to bust a few myths about R:R and how to avoid losing trades.

Before entering a trade, you need to determine 3 things.

1. Entry trigger
2. Stop loss
3. Target

1. Entry trigger = Reasons for entering a trade. There could be multiple reasons or a single reason for entry.

Generally a set of reasons AKA confluence is a higher probability trade and a generally a safer entry.

Example of an entry trigger.


2. Stop Loss.

The price in the opposite direction of the trade where the trade is exited, at a loss.

At this level, the reason for the entry becomes invalidated according to TA and the price can then move in the opposite direction, probabilistically.


3. Target is the possible price level that the asset might touch based on previous trends or confluence AND where a possible reversal could occur.

Target is the next path of least resistance from where the price might reverse.

We will always ONLY use TA to determine all 3.
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Dr Amanda Moehring
Dr Amanda Moehring
@FlyBehaviour
In Academia, people aren’t always supported when they need it. I want to share what @WesternU did when my husband died right after the pandemic shutdown. It should be shared with other uni’s as a model for empathy and proactive care when someone is in crisis.
1/
#AcademicChatter
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