Kicking off the Year in Review for #PICUQI and #PedsICU #MedEd #CCC50 Search strategy included a review of ALL tables of contents of major pediatric and critical care journals, PUBMED search, key collaborative search, asking on @twitter and discussion with experts in the fields.

The numbers on their face for the @FCC RDOF auction are exciting - lots of Gigabit winners. But it’s important to remember the job is just starting. These rural areas don’t magically get Gig today or tomorrow. 1/

The job is only done and the celebration can really only begin once we see that rural Americans are actually going to get the broadband they’ve been promised. 2/

And that’s the rub here - at least from preliminary indications, there are LOTS of question marks clearly hanging out there once you look past the gloss and proclamations. And since we won’t know for maybe 5 years if it worked, due diligence is essential now. 3/

A number of big winners have offered some service but never done Gig. This would be like giving hundreds of millions of $ to firms that have repaved residential streets to now design & build our interstate highway bridges. 4/

A number of big winners are using tech that has done Gig (maybe) only in tightly controlled applications that don’t look anything like rural America. This would be like giving interstate highway $ to firms who’ve built lots of scale models but never actually built a bridge. 5/

So, I want to talk about how sexual harassment and fair pay are linked at Google (and beyond), because I think that's an angle that isn't being highlighted enough in the coverage of these walk-outs. I'm going to frame it largely around my personal experience there. Thread.

When I was sexually harassed by the director of the area I was working in, I was afraid to report it because I was worried that "getting him in trouble" would result in the subtle retaliation of missed leadership opportunities.

I wanted to continue working on the team I was on, because I'd gained a lot of very deep knowledge and expertise in that area, as well as reputation and camaraderie with the other folks working in that area. I didn't want to make the situation more "difficult."

To get promoted at Google, several need to happen: 1. you need opportunities for ownership and leadership above your current level (basically, opportunities to show you're working at the next level you're trying to get promoted to). The work you're "assigned" has a big impact.

2. You need glowing reviews from peers, *at or particularly above the level you're hoping to get promoted to.* Basically, you need people a lot more senior than you to say you're doing awesome work.

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10

Having spent 2020 telling covid denalists that they were overly optimistic about the pandemic, I now look forward to spending 2021 telling covid maximalists that they are overly pessimistic about the end of the pandemic.

Telling a denialist in May that we shouldn't open bars back up = telling a maximalist in February that we should open schools back up.

Look, folks, the math is straightforward. ~13% of Americans have been vaccinated as of this

And the 7 day average continues to rise; we're approach 2 million vaccine doses per day. Meaning that we'll double that ~13% much faster than the two months it took us to get there.

So it's entirely reasonable that absent any other intervention, we should expect to hit ~30% vaccinated by the end of March.