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Here is another very enjoyable conversation, with @Pandata19’s scientific advisory board member, Dr Jay Bhattacharya. Key ideas in this thread.

 We are making world-changing decisions on the basis of evidence that is not very good. Vast scientific evidence tells us that infection fatality rates are much lower than originally expected. A small fraction of people get severe illness. 2/10
The scientific community has been resistant to evidence not supporting the majoritarian view, preferring instead to gin up panic, focusing on the worst case for everything the virus does & the best case for everything lockdowns do, and ignoring the range of uncertainty. 3/10
Academe is a strange place now, with debate stifled. But there's a sense some are opening up to considering opposing views. This is key, since suppression of views stops knowledge from progressing—the end of science. Public health norms of unified messaging complicate this. 4/10
Why did we, from the start, assume we knew nothing about this virus, instead of assuming a reasonable prior? Low susceptibility was evident early on. Assuming any virus is new is hard to square with our deep-time co-evolution with viruses, & their slow evolution. 5/10
A lot of smart people changed their minds about what to do in March, and need to change them back. Our hope has to be that people will lose respect for scientific institutions, and not for science itself. 6/10
From the first day Jay heard about lockdowns, they felt like a violation of everything he knew about public health. Shutting down of schools has been their most shocking manifestation. 7/10
Asymptomatic people and children are at least much less efficient at transmitting. B- and T-cell responses persist after antibody levels have waned, so it is unlikely that people who are reinfected will get severely sick. 8/10
The issue of Long Covid is overstated by the media. Similar to the flu, there are occasional extra-respiratory manifestations, but they appear to be relatively uncommon and seldom serious. 9/10
Fear of the disease prevents young, healthy people from doing the usual thing & shouldering the burden of infection, so the elderly are spared ending up in the exposed group. Then there is an interesting discussion about vaccinations, including who should seek them. Enjoy! 10/10

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Smit Patel
Smit Patel
@snazzysmit
Super excited to share my very first lead-author paper in @ScienceAdvances

Supported by @HIRN_CC @NIDDKgov @UFBME @UFWertheim @ufdiabetes @UMCoEDean
Lead by @Cherie_Stabler & @ashu83

link: https://t.co/FbqVWQ0n5p

This is a thread 👇

Highlights:
⚪️A Lab-on-a-Chip platform for organoids w/ wide capabilities: long-term culture | controlled & dynamic perifusion | in situ spatio-temporal imaging | serial cell assessment | ease of sample retrieval


⚪️Continuous fluidic flow increased local oxygen supply to islets in hydrogels & reduced cellular hypoxia
⚪️Flow increased cellular viability & reduced apoptosis & cell death

⚪️Human islets in hydrogels were highly functional during the 10 day in situ culture in our chips, while islet function was rapidly lost under static conditions
⚪️Glucolipotoxicity study showed a treatment window as small as 2.5 hours can elevate cell death

What are organoids? – A miniaturized version of an organ that imitate an aspect of human interface. They are commonly developed from stem cells in a lab. Human body also produces organoids naturally particularly within the pancreas.
SCIENCE
Stephen Barlow
Stephen Barlow
@SteB777
1) Science denial is destroying our societies, our civilization. Various vested interests, usually right wing ideologues find various scientific facts and information contrary to their agenda, so through propaganda they are orchestrating the public into denying this science.

2) We are seeing this with regard to the COVID virus, where a range of denial is being promoted, ranging from absolute denial the virus exists, to different levels of denial, such as only some people are vulnerable to the virus, to facilitate business as usual.

3) For a long time, to promote business as usual, vested interests have been promoting the denial of the climate and ecological crisis through propaganda. The aim being to create a large enough body of public denial to prevent action which can change anything.

4) We have seen similar patterns over a long time, such as when tobacco companies promoted denial of the emerging scientific evidence of how harmful and addictive tobacco smoking was. This further denial uses exactly the same methods.

5) Understandably, the public can't be educated about everything and have to rely on experts to inform them of concerns about threats to public safety. Malicious vested interests take advantage of this by using pseudo-experts to misinform the public.
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Max Fagin
Max Fagin
@MaxFagin
November is here, and that means a massive shift is coming. And by "massive" I am of course referring to the redefinition of the kilogram unit of mass that the world has been building up to for more than 100 years. Let me explain:


1/ I've had an unhealthy fascination with metrology (the study of measurement) ever since my 2nd year as a physics major when I took a class devoted to duplicating historic physics experiments, so please indulge me for going into heavy detail (get it?) about the kilogram.

2/ So what actually *defines* a unit of measurement? If you're American, you probably know a mile is 5280 feet and a foot is 12 inches and an inch is 2.54 centimeters etc. But where does this chain of definitions end? Is it turtles all the way down?

3/ It's actually not! For all units (even the imperial units used in America) the answers all end with the Système International (SI) unit definitions established and maintained for over 100 years by the Bureau International des Poids et Mesures (BIMP) in France.

4/ At the base of this tower are the SI base units. Just 7 SI base units define every other unit in existence. They are:

Kilogram, kg (mass)
Meter, m (distance)
Second, s (time)
Kelvin, K (temp)
Ampere, A (electric current)
Candela, cd (luminous intensity)
Mole, mol (quantity)
SCIENCE
Rebecca \U0001f983 "Stay the Fuck Home" \U0001f983 Watson
Rebecca 🦃 "Stay the Fu...
@rebeccawatson
So it turns out that an organization I thought was doing good work, the False Memory Syndrome Foundation (associated with Center for Inquiry, James Randi, and Martin Gardner) was actually caping for pedophiles. Uhhhh oops?


Since this, bizarrely, turned out to be one of my longest videos ever (??) here's a quick thread to sum it up for those of you like myself with short attention spans. 1/10

In the '90s the False Memory Syndrome Foundation was founded to call attention to the problem of adults suddenly "remembering" child abuse that never actually happened, often under hypnosis. Skeptics like James Randi & Martin Gardner joined their board. 2/10

A new article reveals that the FMSF was founded by parents who had been credibly and PRIVATELY accused of molestation by their now-adult daughter. They publicized the accusation, destroyed the daughter's reputation, and started the foundation. 3/10

The FMSF assumed any accused pedo who joined was innocent, saying "We are a good-looking bunch of people, graying hair, well dressed, healthy, smiling; just about every person who has attended is someone you would surely find interesting and want to count as a friend" 😬 4/10
SCIENCE
James Bartlett
James Bartlett
@JamesEBartlett
It was great to talk about reproducible workflows for @riotscienceclub @riotscience_wlv. You can watch the recording below, but if you don't want to listen to me talk for 40 minutes, I thought I would summarise my talk in a thread:


My inspiration was making open science accessible. I wanted to outline the mistakes I've made along the way so people would feel empowered to give it a go. Increased accountability is seen as a barrier to adopting open science practices as an ECR

It also comes across as all or nothing. You are either fully open science or your research won't get anywhere. However, that can be quite intimidating, so I wanted to emphasise this incremental approach to adapting your workflow

There are two sides to why you should work towards reproducibility. The first is communal. It's going to help the field if you or someone else can reproduce your whole pipeline.


There is also the selfish element of it's just going to help you do your work. If you can't remember what your work means after a lunch break, you're not going to remember months or years down the line
SCIENCE

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f1talks.pl
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According to @RadioZET_NEWS PKN Orlen (major Polish oil refiner and petrol retailer) is considering entering F1 as a fuel sponsor (supplier) and personal sponsor of Robert Kubica. #F1

Yesterday Kubica was at Orlen's headquarters and met with Polish Prime Minister. #F1
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Anu Satheesh
Anu Satheesh
@AnuSatheesh5
Dhanwanthari Temple, Nelluvai
Thrissur District, Kerala.🚩🚩

ॐ नमो भगवते वासुदेवाय धन्वन्तरये अमृतकलश हस्ताय
सर्वामय विनाशनाय त्रैलोक्यनाथाय श्री महाविष्णवे नमः
#temples

Dhanwanthary Moorthy temple in Nelluvai is one among the ancient temples in Kerala.


Dhanwanthari is the Deva of Ayurveda. It is said that the murthy at the temple was installed by Ashwani Devas and it was the same idol worshipped by Sri. Vasudevar in the Dwapara Yuga. The Dhanvanthari Moorthi is facing towards the west
@SriramKannan77


Smrata-Matrarti-Nasanah', Srimad Bhagavatam states that the one who remembers the name of Dhanwantari will be cured and protected from all the diseases. Temple is known for its Oushada Prasada with Ayuvedic medicinal values, called Mukkudi.


Mukkudi Nivedyam is a very special offering to Dhanwantari. It is prepared by using dry ginger, pepper, pomegranate peel, cumin seed, turmeric, rock salt and other medicinal items. It is offered during 'Usha- Pooja', and is later on distributed to the devotees present there.
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Professor
Professor
@DillikiBiili
So friends here is the thread on the recommended pathway for new entrants in the stock market.

Here I will share what I believe are essentials for anybody who is interested in stock markets and the resources to learn them, its from my experience and by no means exhaustive..

First the very basic : The Dow theory, Everybody must have basic understanding of it and must learn to observe High Highs, Higher Lows, Lower Highs and Lowers lows on charts and their

Even those who are more inclined towards fundamental side can also benefit from Dow theory, as it can hint start & end of Bull/Bear runs thereby indication entry and exits.


Next basic is Wyckoff's Theory. It tells how accumulation and distribution happens with regularity and how the market actually

Dow theory is old but
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Vibhu Vashisth
Vibhu Vashisth
@VIBHU_Tweet
AGAMA SHASTRA:THE SCIENCE BEHIND THE MARVELS OF HINDU ARCHITECTURE

Agama Shastra is a Sanskrit word that means the manual for worship, temple building, rituals etc in Hindu Tradition.From Sanskrit,agama means handed down by tradition and Shastra means a commentary or treatise.


Therefore, Agama Shastra is a collection of ideas that drafts the rules for worship, temple construction, spirituality and rituals. It has been a guideline for many Hindus from ancient times. It's a collection of Sanskrit, Tamil and Grantha scriptures that mostly contains...


...methods of temple construction, idol creation, philosophical doctrines and meditative practices. It came into being after years of assimiliation and from a variety of sources. Some parts of it are pre-vedic while some are post-vedic.


Hindu Temples are not just temples, they are the pride and identity of Hindus. They are the symbols of Hindu unity and their religious aspirations. Temples are the places of spiritual healing and are our connection with the creator almighty.


Temples are the priceless treasure of our History, Heritage ,Art & Architecture. Architecture that mesmerises and spell bounds you. And Agama Shastra is that very text which is responsible for such a mesmerising and spell binding quality and beauty of our Hindu Temples.
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dan spaceman
dan spaceman
@ohlaika
I'm gonna do my other star wars thread tomorrow, which will primarily be me yelling at a @RowanKaiser-shaped strawman for calling the First Order and The Resistance "cosplayers who the rest of the galaxy has to deal with"

the deal w/the New Republic, the First Order, and the Resistance is very weird and complex and I actually take issue with how Story Group frames the actual conflict.

pre-TFA stuff is presented as a "cold war" between the New Republic and the remnants of the Empire that form the First Order, which 100% makes sense.

But they frame the First Order's attack on the Hosnian system and the subsequent battle that takes place across TFA and TLJ as a full on war when it's very clearly a coup. A war implies at least equal standing, but the First Order completely wrecks shop and takes over the galaxy.

ok never mind I'm fucking doing this now.

The First Order fleet we see in TLJ is *not* the entire fleet of the First Order (I don't even think Starkiller Base was their main base of operations honestly, it couldn't have been considering they were operating out of Wild Space)
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