In Academia, people aren’t always supported when they need it. I want to share what @WesternU did when my husband died right after the pandemic shutdown. It should be shared with other uni’s as a model for empathy and proactive care when someone is in crisis.
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#AcademicChatter

With @franklowery our new study on attributes of T cells that contribute to successful cell therapy in cancer patients in @ScienceMagazine today w/ colleagues @slgoff_SB, @NCI_CCR_SB @theNCI a TL;DR thread on key findings with caveats :) 1/10

has a long history of using tumor infiltrating T cells (TILs) to treat cancers since well.. before I was even born. We analyzed our most successful melanoma ACT trial for cell surface phenotypes in TIL infusion products of patients (aPD1/immunotherapy naive) /2

Surprisingly we found a CD39- TIL subset (CD39-CD69-, DN) associated with ACT-response. TBH we were expecting the opposite (CD39+). We only included CD39 bcz multiple groups (e.g. Simoni et al, 2018) had reported CD39+ as enriching for anti-tumor/neoantigen reactive T cells. /3

CD39- DN TILs RNA/epigenetics resemble stem-like memory progenitors, and in vitro were able to self-renew, and give rise to other CD39+ subsets. OTOH the most dominant subset of patient infusion products were CD39+ CD69+ (DP) and these guys were terminally differentiated.. /4

So, to clarify we specifically analyzed tumor-specific mutation-reactive Tcells. Turns out, ACT-responders had pool of neoantigen-reactive TILs in the CD39- phenotype, while non-responders did not (despite other irrelevant CD39- Tcells) -> not all CD39- T cells are bystanders /5

It is astonishing that most of cognitive science ignores an obvious reality. That there are two kinds of humans.

Tomasello has a very credible hypothesis that what distinguishes humans from the great apes is the inclination towards shared intentional behavior. What is innate is the disposition and like personalities, it is what defines our cognition as we grow.

If cognitive preference is so critical in cognitive development then why is it that we seem to have completely ignored the difference in cognitive preferences between men and women?

Humans are that species of primates that wandered out into the savannah. The savannah is different enough from a dense jungle to exert the evolutionary pressures that encourage the development of planning and forecasting skills.

Furthermore, human infants required a disproportional amount of effort to rear. This meant the specialization of roles between women who were responsible for rearing offspring and men who were responsible for bringing home the bacon. Failure in either implied death.

What is carbon capture? And how does it work?

While carbon capture is regularly discussed in the media, no one really ever explains what it is.

Below is a quick thread discussing the technology behind traditional carbon capture 👇

Carbon capture is broadly the "capture" of CO2 emissions from a power plant or other type of industrial facility.

Technology is connected to the "tailpipes" of these facilities and is used to remove CO2 from the plant exhaust.

Once the CO2 is removed from the plant exhaust, it is typically pressurized and sent under ground for permanent storage.

This step is called "sequestration" and is why experts often talks about "carbon capture and sequestration" or "CCS".

So how do you "capture" the CO2 molecules from exhaust?

Currently, one of the most economic forms of carbon capture is called "amine-based" capture.

An "amine" is a special liquid chemical which selectively grabs on to CO2 molecules.

To get the amine to grab on to the CO2, the amine is put into the top of a large column, while the exhaust is put into the bottom of the column.

The exhaust bubbles up through the column, and the amine drips down.

The liquid amine and gas exhaust mix in the column.