BC HEALTH
Saved by @CodyyyGardner

THREAD
I created a simple table to illustrate the individual impact of the "flexible second dose timing" now recommended in the UK.

Coincidentally, @bob_wachter & @ashishkjha just tackled the US policy question in this important piece. 1/
https://t.co/n5bHkdIo0c

 I based this on recent statements from the UK chief medical officers, JCVI, and what we know from prior vaccine development. 2/

JCVI: https://t.co/6FQ25d6MFE

UK Chief Medical Officer (CMO) statement: https://t.co/RTpAIqgE1i

CMO letter to the profession: https://t.co/4WeexrVYWX
This table and thread focuses on the AZ vaccine, where more data on a delayed second dose is available than with the Pfizer vaccine. It is not intended to address questions about single-dose regimens or mix & match approaches. 3/
In the table, persons “A” and “B” both receive their first dose in January. “A” receives their second dose in February (4 weeks later), and “B” receives their second dose in April (12 weeks later). “C” receives their first dose in April and second dose in May (4 weeks later). 4/
I made a qualitative comparison the potential efficacy during the two months between “A” and “B’s” second dose, as well as the potential longer-term efficacy after “B” receives their second dose. 5/
For the two-month period between the timing of “A” and “B’s” second dose, the level of protection for “A” may be greater than “B,” as “A” has received their second dose, although JCVI suggests that most of this early protection is provided by the first dose. 6/
JCVI says first-dose protection against hospitalization is high, so for that two month interval, I’ve assumed “B” is expected to be protected against the more severe forms of COVID-19 (“+”). 7/
After “B’s” second dose in April, we expect a more robust, higher quality and longer-lasting immune response than “A,” as is often seen with longer intervals in a primary vaccination series and supported by AZ’s data immunogenicity data. 8/
https://t.co/cqKIpomUHg
The bottom line is that “A” may see some protective benefit over “B” for two months (although “B” is expected to be protected against severe COVID during that time), but “B” is expected to have better long-term protection after they receive their second dose at 12 weeks. 9/
In other words, for the two months between “A” and “B’s” second dose: A>B>C

For the longer term, after “B” receives their second dose: B>A=C

10/
At a population level, this strategy could double the number of people immunized immediately while production ramps up. Many in category “C” could shift to “B.”

This assumes immunization programs are keeping up with the number of doses available. 11/
A few important caveats: (1) the assumption of sustained efficacy after the first dose is based on an exploratory analysis in the age 18-55 population. This needs to be confirmed in the older adult population. Exploratory analyses have limitations, esp if not pre-specified. 12/
(2) the assumption that a longer schedule (“B”) will result in a higher-quality, more durable immune response is based on immunogenicity data and experience with other vaccines. The efficacy impact will have to be confirmed. 13/
(3) we need to confirm that vaccine protection against the new strain is comparable after the first and second doses, given the affinity maturation expected with a second dose. 14/
Some virologists have raised the theoretical concern that a change in schedule could promote emergence of vaccine escape mutants. This is an important consideration that has implications for single-dose vaccine development and WHO’s minimum vaccine efficacy threshold of 50%. 15/
Again, this illustration is based on statements from UK authorities, AZ’s published data, and what is known from prior vaccine development. It is not a prediction of the future or what will happen to any individual, and is subject to updates as new data becomes available. 16/
I hope this helps people understand the practical ramifications of the UK recommendations and the pros/cons at individual and population levels. The urgency of the question is driven by the emergence of the new variant in the UK as well as the limited supply of vaccine. 17/
Thanks to our vaccine CMO, Dr. Gary Dubin for his input. More thoughts and links to others' views in the thread below.

I went through this exercise to clarify my own views and thought others might find it useful. Please take it in that spirit! 18/ https://t.co/2vzJ9Sdfc4

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Patrick Strudwick
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I’m deeply saddened to learn that Dr Joseph Sonnabend, one of the most important figures in the history of AIDS, died yesterday. I spent time with him in 2018 for one of the last interviews he ever gave. Let me tell you about this man and what he did:

Sonnabend was one of the first doctors to raise the alarm. In 1979, while running a sexual health clinic in Greenwich Village, he wrote to the NY Health Dept to warn them of the symptoms he was seeing: low white blood cell counts, enlarged lymph nodes. He didn’t get a reply. 2/

So he kept speaking out. When a patient of his developed a very rare cancer – Kaposi’s Sarcoma – he linked up with a dermatologist at NYU who said that over a dozen gay men had it. Sonnabend knew there was something very wrong. He started working at the lab at NYU — for free. 3/

It was soon after this in 1981 that the New York Times famously reported “Rare Cancer Found In 41 Homosexuals”. The next decade would kill most of Sonnabend’s patients and friends — and all of his lovers. What Sonnabend did was to fight for every single of them. 4/

Want to know who was the first to publish advice to wear a condom? That was Sonnabend. In 1983 he co-authored the first safe sex leaflet to fight AIDS: “How To Have Sex In An Epidemic”. 5/
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Starks\u262a\ufe0f\U0001f1f9\U0001f1e9
Starks☪️🇹🇩...
@MegaIntelIect
Thread on how atheism leads to mental retardation (backed with medical citations🧵💉)

To start with, atheism is an unnatural self-contradicting doctrine.

Medical terminology proves that human beings are naturally pre-disposed to believe in God. Oxford scientists assert that people are "born believers".

https://t.co/kE0Fi588yn
https://t.co/OqyXcGIMJn


It should be known that atheism could never produce an intelligently-functioning society and neither ever will.

Contrastingly, Islam produced several intellectuals & polymaths, was on the forefront of scientific development, boasting 100% literacy


It is also scientifically proven that atheism led to lesser scientific curiosity and scientific frauds, which is also why atheists incline to pseudo-science.

Whereas, religion in general and Islam in particular boosted education.

https://t.co/19Onc84u3g


Atheists are also likely to affected by pervasive mental and developmental disorders like high-functioning autism.

Cognitive Scientists and renowned Neurologists found that more atheism is leads to greater autism.

https://t.co/zRjEyFoX3P
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Eric Feigl-Ding
Eric Feigl-Ding
@DrEricDing
NEW—CDC was truly suffocated by Trump WH at every turn. Kyle McGowan, a former chief of staff at CDC, and his deputy, Amanda Campbell, witnessed WH dismissal of science, WH’s slow suffocation of CDC’s voice, meddling in messages & siphoning of CDC budget.
https://t.co/HeuNbUggiw


2) ““Everyone wants to describe the day that the light switch flipped—It didn’t happen that way—more of like a hand grasping something, and it slowly closes, closes, closes, closes until you realize that, middle of the summer, it has a complete grasp on everything at the CDC”

3) “Mr. McGowan and Ms. Campbell, both 34, say they tried to protect their colleagues against political meddling from WH and HHS but was largely stifled by the Trump administration.

4) “The White House insisted on reviewing — and often softening — the C.D.C.’s closely guarded coronavirus guidance documents, the most prominent public expression of its latest research and scientific consensus on the spread of the virus.”

5) “The documents were vetted not only by the White House’s coronavirus task force but by what felt to the agency’s employees like an endless loop of political appointees across Washington.
Mr. McGowan recalled a White House fixated on the economic implications of public health.
HEALTH
Momentswithbren Consulting
Momentswithbren Consul...
@MomentsWB
Pathways to Public Policy Careers for those interested and looking for global opportunities

Public policy is made when a governing body attempts to address an issue of widespread public concern, such as health care. The process often runs in cycles and can take years.

■After new laws are created, Policy Implementation occurs, often involving federal agencies, state and local governments, bureaucratic entities, and NGOs. Courts get involved as laws and policies are challenged on a variety of fronts.

■Analysis and Evaluation occurs throughout the cycle and involves many players. Policies may be changed — and the cycle begins again.

What is the best advice for someone pursuing a career in public policy?

People often find their way to public policy careers because of an

interest in a particular substantive area. Public policy work can be found in virtually any subject area.

Your ears should perk up when you hear the words “Center for,” “Institute,” “Association,” and “Foundation” because they represent potential employers.

Public policy majors work in the public, private, and nonprofit sectors, such as a government agency or advocacy group.

Continuing education, such as a certification or fellowship, can also advance your career as someone interested in public policy and politics.
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Eli Tyre
Eli Tyre
@EpistemicHope
I know some people who seem (to me) more concerned with receiving VALIDATION for their mental health issues than solving them.

They seem to care most about other people BELIEVING their problems are real.

I'm curious about this.

Like, it's more important to them that people know how debilitating their anxiety is, than to overcome the anxiety.

Or it's important to them that others believe that they're actually depressed, not "just sad."

Or they want people buy into the narrative that they've been traumatized, and might be something like offended if someone minimizes that.

What do we make of this?

1. One possibility is that if solving the problems seems hopeless or even just really hard, you need external support to be able to cope.

If no one cuts you slack because of your mental health stuff, maybe you're in a really bad place, so you need people to believe you.
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Unfortunately the "This work includes the identification of viral sequences in bat samples, and has resulted in the isolation of three bat SARS-related coronaviruses that are now used as reagents to test therapeutics and vaccines." were BEFORE the


chimeric infectious clone grants were there.https://t.co/DAArwFkz6v is in 2017, Rs4231.
https://t.co/UgXygDjYbW is in 2016, RsSHC014 and RsWIV16.
https://t.co/krO69CsJ94 is in 2013, RsWIV1. notice that this is before the beginning of the project

starting in 2016. Also remember that they told about only 3 isolates/live viruses. RsSHC014 is a live infectious clone that is just as alive as those other "Isolates".

P.D. somehow is able to use funds that he have yet recieved yet, and send results and sequences from late 2019 back in time into 2015,2013 and 2016!

https://t.co/4wC7k1Lh54 Ref 3: Why ALL your pangolin samples were PCR negative? to avoid deep sequencing and accidentally reveal Paguma Larvata and Oryctolagus Cuniculus?
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If u are looking to enter a scrip just before the breakout
what would u look for?
How would u identify scrips just before breakout?

Here are a few pointers
Carefully understand the them and use at ur own discretion
(All comments r compiled from a question i posed)

1/23

Price is testing the same resistance repeatedly since long.
But now in recent times it's forming multiple candles near the same resistance with low volume.
Observe it and see for opposite move.
As soon as u get a positive candle, get in to it.

2/23

1. Volume buildup (vol > when resistance point created) along with, increase in OI, increase in delivery % on HTF
2. On LTF, price stalling around breakout area for at least 1-2hr.
3. No major events.

3/23

Stock reaching breakout LVL with HL-HH
Contraction of price and volume near it especially near 20 days ma.
If there is any breach of the latest HL it should be followed by a bullish candle with good volume.
Left side of the chart has a rally with a very steep slope of ma.

4/23

Number of wide range green bars with high volumes.
If stock is at its ATH then it adds more conviction bcz there wont b supply after that point

Consolidation below the resistance, volume of the candles & strong bullish candle closing at near highs just below the resistance

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Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
@EricTopol @NBA @StephenKissler @yhgrad B.1.1.7 reveals clearly that SARS-CoV-2 is reverting to its original pre-outbreak condition, i.e. adapted to transgenic hACE2 mice (either Baric's BALB/c ones or others used at WIV labs during chimeric bat coronavirus experiments aimed at developing a pan betacoronavirus vaccine)

@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice


@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2


@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj


@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
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ArmaniTalks \U0001f399\U0001f525
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Shy people are either overthinking or highly observant of the social setting.

And in many cases it can be both.

'So what do I do?'

You learn the 75/25 law.

'What is that?'

The law of charisma...👇

Let's address the over thinkers first.

Do you have any idea why you overthink?

'Yea. Because others are judging how shy I am.'

Incorrect.

Others are thinking about themselves, not you.

But the fact that you think they are thinking about you, you fuck up the interaction.

Now you stay in your head too much & avoid the present moment.

A major no no in the social world.

Your tendency to think that others are judging you for being shy, coincidentally makes you more shy.

And that's when you start giving off a strange vibration to the social setting.

This is when you begin attracting comments like 'why are you so quiet?'
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Anu Satheesh
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@AnuSatheesh5
Alathiyur Hanuman Temple
Malappuram, Kerala 🚩
#keralatemples

One of the Powerful Anjaneya Temples in Kerala. Hanuman temple is adjacent to Shri Ramar Sannidhi. Here Hanuman's head is tilted towards the left to hear Shri Rama's words. Shri Rama is entrusting Hanuman👇


Task of locating Mata Sita in Lanka.

Prathishta of Hanuman is done by Sage Vasishta. Eventhough this is Shri Ram Temple, importance is given to Hanuman
Shri Rama shares with Hanuman the Abhignana Vaakhyam, the words that would enable him to gain the confidence of Mata Seetha.


Hanuman stands leaning a little towards the left, showing how he hear Shri Rama's words and also assuring him Your Wish is my Command.
The Vigraham of Hanuman gives us the Strength, Confidence and Bhakthi.
There is a place marked here to show Hanuman’s leap to Lanka over sea.


Devotees run and leap over the stone for better health.Aval Naivedhyam is famous here. Those children who have nightmares are told to pray Alathiyur Hanuman. Mantra 👇

Alathiyur Hanumane
Pedi Swampnam kanarudhe
Pedi Swapnam Kandalo
Val Kondu Thattiyunarthename
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