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Saved by @BillyBostickson

@NBA @StephenKissler @yhgrad B.1.1.7 reveals clearly that SARS-CoV-2 is reverting to its original pre-outbreak condition, i.e. adapted to transgenic hACE2 mice (either Baric's BALB/c ones or others used at WIV labs during chimeric bat coronavirus experiments aimed at developing a pan betacoronavirus vaccine)

 @EricTopol @NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice https://t.co/TNE4tuLkqN
@EricTopol @NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2 https://t.co/B3eR764c1Z
@EricTopol @NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj
@EricTopol @NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
@EricTopol @NBA @StephenKissler @yhgrad Mice!
A mink-associated variant carrying Δ(69-70)-Y453F-F486L-N501T-M1229I mutations was also able to utilize mouse Ace2. In addition, all variants carrying an N501Y mutation, a shared feature of UK, South Africa, & Brazil VOC strains, efficiently use mouse Ace2 orthologs.
@EricTopol @NBA @StephenKissler @yhgrad Topolino!
"Moreover, the K417N-E484K-N501Y mutations found in the South Africa variant 501Y.V2 even enable the virus to utilize rat Ace2 more efficiently than using human ACE2. These data suggest that rats and mice may (have) be(en) able to harbor and spread these variants"?
@EricTopol @NBA @StephenKissler @yhgrad Above taken from:
Circulating SARS-CoV-2 variants B.1.1.7, 501Y.V2, and P.1 have gained ability to utilize rat and mouse Ace2 and altered in vitro sensitivity to neutralizing antibodies and ACE2-Ig
https://t.co/j9qEcUz4ea
Well worth a read!
@EricTopol @NBA @StephenKissler @yhgrad even the mink variants were mouse ACE2 adapted, what a surprise...now, who would have expected that?
@EricTopol @NBA @StephenKissler @yhgrad Serial passaging of virus in mouse lungs results in adaptive mutations that increase viral infectivity
MASCp6 genome contains 5 mutations compared to its parental strain IME-BJ05, resulting in four amino acid residue changes in the ORF1ab, S, and N genes, respectively (Fig. 3A)
@EricTopol @NBA @StephenKissler @yhgrad The N501Y mutation seems to provide a more favorable interaction with mouse ACE2 for docking and entry, thus leading to the increased virulence phenotype in mice.
Adaptation of SARS-CoV-2 in BALB/c mice
https://t.co/I90OOCJg7o
@EricTopol @NBA @StephenKissler @yhgrad Protein-coding mutations in SARS-CoV-2 B.1.1.7 virus variant.
A) open reading frames (dark purple arrows) and proteins resulting from cleavage of ORF1ab polypeptide into non-structural proteins (light purple). 17 protein-coding mutations are annotated (top)
@EricTopol @NBA @StephenKissler @yhgrad which includes 14 non-synonymous mutations and 3 deletions spanning 5 viral proteins. B) Expansion of the genomic region from spike to N protein for visualization purposes.
@EricTopol @NBA @StephenKissler @yhgrad "N501Y mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice"
https://t.co/FOfZg8SiQU
@EricTopol @NBA @StephenKissler @yhgrad Differential efficiencies to neutralize the novel mutants B.1.1.7 and 501Y.V2 by collected sera from convalescent COVID-19 patients and RBD nanoparticle-vaccinated rhesus macaques
https://t.co/fBHaTllKvJ
@EricTopol @NBA @StephenKissler @yhgrad Just to annoy people
Virology: the problem with ‘leaky’ vaccines
Fresh evidence supports the theory that some vaccines lead to the evolution of more virulent viral strains
https://t.co/ttyM9J2idI

More from Billy Bostickson 🏴👁&👁 🆓

Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
Tip from the Monkey
Pangolins, September 2019 and PLA are the key to this mystery
Stay Tuned!


1. Yang


2. A jacobin capuchin dangling a flagellin pangolin on a javelin while playing a mandolin and strangling a mannequin on a paladin's palanquin, said Saladin
More to come tomorrow!


3. Yigang Tong
https://t.co/CYtqYorhzH
Archived: https://t.co/ncz5ruwE2W


4. YT Interview
Some bats & pangolins carry viruses related with SARS-CoV-2, found in SE Asia and in Yunnan, & the pangolins carrying SARS-CoV-2 related viruses were smuggled from SE Asia, so there is a possibility that SARS-CoV-2 were coming from
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Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
1. Omicron Thread - A Compilation of Opinions

"finally, the time has slip and slid its slimy course through to us - and we're the vicious bastards of the new generation. we do not relent, and we should not be held to account for our ancestral faults"

https://t.co/mhJO6yOQRE


2. The Letter Chosen by the WHO

"It's amazing that the Xi variant seems to have somehow managed to evade detection..."

via @readomain

Why 'Omicron', Not 'Nu' or 'Xi'?

WHO Says Two Letters in Greek Alphabet Jumped to 'Avoid Stigma'

https://t.co/xnGR9XK2tF


3. The Omicron variant has been found in nearly every province of South Africa, as well as Botswana, Belgium, Israel, UK and Hong Kong.

This month, Israel held an exercise, The “Omega Exercise”, meant to prepare for a hypothetical, new COVID-19

4. Omicron Infographic

(appeared in Germany and Italy now)

https://t.co/oNFYBH1F1o


5. Overview of Omicron (B.1.1.529) from @nicd_sa

https://t.co/HN9csJqK0z
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Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
1. Uncle Sham's sticky fingers?
Neither the name of the biologist nor what "program" she was working for when this happened in 2012 was ever

2. Maculopapular eruption observed on the back and arms of 25-year-old female wildlife biologist infected with a novel paramyxovirus related to rubula-like viruses isolated from fruit bats


3. Sosuga Virus
In 2012, a female wildlife biologist experienced fever, malaise, headache, generalized myalgia and arthralgia, neck stiffness, and a sore throat shortly after returning to the United States from a 6-week field expedition to South Sudan and Uganda.

4. She was hospitalized, after which a maculopapular rash developed and became confluent. When the patient was discharged from the hospital on day 14, arthralgia and myalgia had improved, oropharynx ulcerations had healed, the rash had resolved without desquamation

5. blood counts & hepatic enzyme levels returned to reference levels. After several known suspect pathogens were ruled out as the cause of her illness, deep sequencing & metagenomics analysis revealed a novel paramyxovirus related to rubula-like viruses isolated from fruit bats
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Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
Digital Operations Group (DOG) 77th Brigade
A pathetic digestive biscuit munching bunch of British Berks from civvy street whose badge dishonours the Chindits.
Sleazy Media Manipulators who usually fail to deliver "influencing activity & products" to counter narratives of others


“If everybody is thinking alike then somebody isn’t thinking”
Just about sums up their Covid-19 "narrative"
“Behavioural change is our USP [unique selling point]”
They fail every time, doubt they could even sell their asses to soldiers at Denison Barracks

More on this pathetic bunch of Trolls scrounging a living from honest taxpayers' money to sell offal scraped off the Butcher's

Why are these little British trolls all over Twitter lately?
The have been ordered to counter "Covid- 19 Myths"
One of these is Myth No.3 (see image)
2004-Factsheet-Russia-Myths-COVID-19_en.pdf
https://t.co/PxjOPJjWH0


🐇🕳️💩
https://t.co/r6n1t1wYvG
https://t.co/aLuzKktcZv
https://t.co/zFmaD9yadQ
https://t.co/UkSdag9U5H
https://t.co/3N3XwF9Drj
https://t.co/ZyKXL2uLzB
https://t.co/OIlpoMVMcA
https://t.co/e0W3qWkwvL
https://t.co/NMdiTqtU4u
https://t.co/gzYiVWeTJf
ALL
Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
1. Strange goings on down at Uncle Sam's Farm in Ukraine?

h/t @DrKevinWMcCair1 video:

https://t.co/1lrFeWcakB

From Daily Expose:

U.S. DoD awarded a contract for ‘COVID-19 Research’ in Ukraine 3 months before Covid was known to even

2. The findings seem to be kosher and can "currently" be confirmed by:

1. checking the DOD Award to Black & Veatch
CONT_IDV_HDTRA108D0007_9700, here:

https://t.co/G5ZEUhPm5U

2. click the tab for sub-awards

3. 7th down from top

4. 19-6192 is the sub-award ID

5. Note Date


3. Download the CSV file by clicking top right:

Again Data is confirmed (with more detail in Column 32 in the csv file)


4. CSV Details (Column 32)

Note Kiev, Ukraine Mentioned and Date 2019


5. CSV Details (2)

Mentions Labyrinth's HQ in Saint Petersburg, Florida, not Russia ;)

URL in CSV directs to original URL

https://t.co/G5ZEUhPm5U

Copy & Paste URL, not click.

Last column with date does not refute finding, it is:

"subaward_fsrs_report_last_modified_date"
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More from All

Aditya Todmal
Aditya Todmal
@AdityaTodmal
A Thread on the Boss himself @Mitesh_Engr

Mitesh Sir's Positional Option Selling 101:

• How to find direction
• Which options to sell
• How to deploy capital
• Exit criteria
• What ROI he targets weekly
• What % risk he takes

Done with the help of @niki_poojary


How @Mitesh_Engr Sir finds the direction?

• Daily charts S/R
• 75 min charts S/R
• Intraday trend
• Always play directional
• Never trades in strategies


Which options to sell in weekly expiry according to @Mitesh_Engr?

• Weekly candle High/Low
• Sell 1% away options from those
• Exit when levels breached


Position Sizing by @Mitesh_Engr Sir.

How to deploy your capital?

• First sell 20%
• Pyramid the next day
• When to exit
• What to do when view goes wrong
• What to do with idle capital


Some important tweets of @Mitesh_Engr Sir

• What Data to look at
• ROI for safe players per month
• Max risk per day
• Gather knowledge and play directional
• Never play strategies
OPTIONS LEARNING , ALL , MPLEARNINGS
Anu Satheesh
Anu Satheesh
@AnuSatheesh5
Puthucode Annapoorneshwari Temple,
Palakkad, Kerala 🚩
#keralatemples
अन्नपूर्णे सदापूर्णे शङ्करप्राणवल्लभे 
ज्ञानवैराग्यसिद्ध्यर्थं भिक्षां देहि च पार्वति 

Temple is also called Puthukode Bhaghavathy Kshetram
Parasurama did Prathishta of Devi here. Temple is one amoung 👇


108 Durga temples
Navarathri festival is celebrated in a grant manner here. Annadanam is done daily on these days. The Idichu pizhinja payasam/ Chathachatayam is the main nivedyam in Annapoorneswari temple during Navarathri.
In the mornings, Devi Mahatmyam and Sundarakandam are


recited here daily.
Sri Godavarma Raja gifted lots of rice fields for the maintenance of the temple.
Annapoorneshwari holds Shanku and Chakra in her hands. Puthucode Annapoorneswari Temple is managed by the Naduvil Madom Devaswom.
🙏🕉🙏
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Vibhu Vashisth
Vibhu Vashisth
@VIBHU_Tweet
LACHIT BORPHUKAN : AN UNSUNG WARRIOR OF THE AHOM KINGDOM & THE GREAT BATTLE OF SARAIGHAT

Originally named as Lachit Deca, Lachit Borphukan, the fierce and invincible Ahom Commander, was born during the early 17th century at Betioni in the Golaghat district of modern Assam.


His father, Momai Tamuli Borbarua was the ‘Governor’ of the kingdom and also ‘Commander-in-Chief’ of Ahom army under King Pratap Singha during his reign starting from 1603 to 1639. Lachit received military training from an early age and joined the Ahom King Jayadhvaj Singha...


...(1648-1663) as a scarf-bearer.  The post ‘scarf-bearer’ or ‘Soladhara Barua’ is considered as a part of the incumbent king’s personal staff. Owing to his military training Lechit was appointed "Ghora Barua", Supdt. of the Royal horses. When Chakradhwaj Singha became king..


..of Ahom dynasty in 1663,he appointed him Suptd. of The Royal Guards &finally he was appointed as Borphukan by the king.Then onwards,he was known as Lachit Borphukan.Borphukan used to be top councillor in Ahom Kingdom. This position was embedded with executive & judicial powers.


Assam was facing incessant Islamic invasion since Jan1662, when Mughal General Mir Jumla II attacked Ahom capital Gargaon. He never defeated Ahom king Jayadhwaja Singha as king retreated to hill &continued Guerrilla warfare.Prolonged fight &prospect of stalemate disturbed Jumla.
ALL
Ben Meer
Ben Meer
@SystemSunday
The best morning routine?

Starts the night before.

9 evening habits that make all the difference:

1. Write down tomorrow's 3:3:3 plan

• 3 hours on your most important project
• 3 shorter tasks
• 3 maintenance activities

Defining a "productive day" is crucial.

Or else you'll never be at peace (even with excellent output).

Learn more


2. End the workday with a shutdown ritual

Create a short shutdown ritual (hat-tip to Cal Newport). Close your laptop, plug in the charger, spend 2 minutes tidying your desk. Then say, "shutdown."

Separating your life and work is key.

3. Journal 1 beautiful life moment

Delicious tacos, presentation you crushed, a moment of inner peace. Write it down.

Gratitude programs a mindset of abundance.

4. Lay out clothes

Get exercise clothes ready for tomorrow. Upon waking up, jump rope for 2 mins. It will activate your mind + body.
ALL
Ax
Ax
@AchuthArora
@aldothetrainer @Artofphysique_ @buzz_chronicles @rattibha @SaveToBookmarks save as Workouts
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Hypertroph | Fitness Coach
Hypertroph | Fitness C...
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Transform your body in next 6 months.

People will charge INR 27,000+ for this course.

I am giving away the entire course for FREE:


Module 1:
Build your Fat Loss Diet Plan

· Step by Step Tutorial
· Length: 26

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SK
SK
@sk_diary1
Margatha Natarajar murthi - Uthirakosamangai temple near Ramanathapuram,TN
#ArudraDarisanam
Unique Natarajar made of emerlad is abt 6 feet tall.
It is always covered with sandal paste.Only on Thriuvadhirai Star in month Margazhi-Nataraja can be worshipped without sandal paste.


After removing the sandal paste,day long rituals & various abhishekam will be https://t.co/e1Ye8DrNWb day Maragatha Nataraja sannandhi will be closed after anointing the murthi with fresh sandal paste.Maragatha Natarajar is covered with sandal paste throughout the year


as Emerald has scientific property of its molecules getting disturbed when exposed to light/water/sound.This is an ancient Shiva temple considered to be 3000 years old -believed to be where Bhagwan Shiva gave Veda gyaana to Parvati Devi.This temple has some stunning sculptures.
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AKASH
AKASH
@AKASHBH95801446
THE SCIENCE BEHIND YAJNA

Fire is, of course, one of the greatest discovery of mankind. Our control over the fire dramatically changed the entire human habits; earlier it was used to cook food, protection from animals and to stay warm.


Among the many applications of fire, one is Yajna (यज्ञ, yajña); also called as Havana (हवन) or Agnihotra (अग्निहोत्र).
Yajna is elaborately described in Yajurveda. In Yajurveda, Yajna is the greatest among all works (Karman). One can purify his /her soul by performing Yajna.

In Vedic culture, it is thought that the holy fire is the mediator between Gods and us; when the offerings are made to Yajna with chanting mantras, it directly reaches the Gods, who bless the people with rains, food, health, and good luck.

According to Apastamba Sutra, the definition of Yajna is Vedic sacrifice; an act by which we surrender something for gods e.g. grains (Anna), pulse, milk and milk product (ghee, butter, curd) fruits, plant juice (soma), etc.

As we said; Yajna is the contact medium for gods and

to seek their blessings.

There are many types of Yajna performed by Hindus for e.g.,

1. Rajsuya Yajna
2. Ashwamedha Yajna
3. Chaaturmasya Yajna
4. Vaajpey Yajna
5. Purushmedha Yajna
6. Sarvamedha Yajna
RELIGION
Jonathan Ware
Jonathan Ware
@ReassessHistory
Rhino Barges

One of the dullest, coolest, more bizarre and fascinating pieces of kit used in Normandy.

Which NO ONE REALLY CARES ABOUT.

BUT I DO AND YOU SHOULD TOO.
/1

#WW2 #SWW #History


Planning for Overlord and Neptune had a serious snag, how to get troops from LSTs onto the beach as simply ramming them onto the beaches and dropping the ramp was known to damage the exceptionally vulnerable LSTs and felt to be unsustainable in the mid to long term. /2


LSTs were essential in sustaining Overlord's progress and were a subject of major headaches in the planning phase, and a real subject of friction when it came to launching additional amphibious operations such as Dragoon.

A single LSTs loss represented a capability nick. /3


So, logic dictated, we don't really want these remarkable but rare and highly valuable vessels constantly doing beach landings, we want something to act as a medium between ship to shore, and in came the (mostly) American designed Rhino. /4


I fucking love Rhinos.

Seriously.

Graceful lines of pure industrial pedigree.

Modular.

LOOK AT IT. /5
HISTORY
Anumah, Abdulraheem Okehi \U0001f468\u200d\U0001f52c\U0001f1f3\U0001f1ec \U0001f1eb\U0001f1f7 \U0001f1f5\U0001f1f9 \U0001f1ea\U0001f1f8
Anumah, Abdulraheem Ok...
@AnumahABD
Department List of UCAS-China PROFESSORs for ANSO, CSC and UCAS (fully or partial) Scholarship Acceptance
1) UCAS School of physical sciences Professor
https://t.co/9X8OheIvRw
2) UCAS School of mathematical sciences Professor

3) UCAS School of nuclear sciences and technology
https://t.co/nQH8JnewcJ
4) UCAS School of astronomy and space sciences
https://t.co/7Ikc6CuKHZ
5) UCAS School of engineering

6) Geotechnical Engineering Teaching and Research Office
https://t.co/jBCJW7UKlQ
7) Multi-scale Mechanics Teaching and Research Section
https://t.co/eqfQnX1LEQ
😎 Microgravity Science Teaching and Research

9) High temperature gas dynamics teaching and research section
https://t.co/tVIdKgTPl3
10) Department of Biomechanics and Medical Engineering
https://t.co/ubW4xhZY2R
11) Ocean Engineering Teaching and Research

12) Department of Dynamics and Advanced Manufacturing
https://t.co/42BKXEugGv
13) Refrigeration and Cryogenic Engineering Teaching and Research Office
https://t.co/pZdUXFTvw3
14) Power Machinery and Engineering Teaching and Research
EDUCATION