1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 30, 2021
"we generated a mouse model expressing hACE2 by using CRISPR/Cas9 knockin technology. In comparison with wild-type C57BL/6 mice, both young & aged hACE2 mice sustained high viral loads... pic.twitter.com/j94XtSkscj
@NBA @StephenKissler @yhgrad B.1.1.7 reveals clearly that SARS-CoV-2 is reverting to its original pre-outbreak condition, i.e. adapted to transgenic hACE2 mice (either Baric's BALB/c ones or others used at WIV labs during chimeric bat coronavirus experiments aimed at developing a pan betacoronavirus vaccine)
1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 2, 2021
Human\u2013viral molecular mimicryhttps://t.co/irfH0Zgrve
Molecular Mimicryhttps://t.co/yLQoUtfS6s https://t.co/lsCv2iMEQz
A mink-associated variant carrying Δ(69-70)-Y453F-F486L-N501T-M1229I mutations was also able to utilize mouse Ace2. In addition, all variants carrying an N501Y mutation, a shared feature of UK, South Africa, & Brazil VOC strains, efficiently use mouse Ace2 orthologs.
"Moreover, the K417N-E484K-N501Y mutations found in the South Africa variant 501Y.V2 even enable the virus to utilize rat Ace2 more efficiently than using human ACE2. These data suggest that rats and mice may (have) be(en) able to harbor and spread these variants"?
Circulating SARS-CoV-2 variants B.1.1.7, 501Y.V2, and P.1 have gained ability to utilize rat and mouse Ace2 and altered in vitro sensitivity to neutralizing antibodies and ACE2-Ig
Well worth a read!
MASCp6 genome contains 5 mutations compared to its parental strain IME-BJ05, resulting in four amino acid residue changes in the ORF1ab, S, and N genes, respectively (Fig. 3A)
Adaptation of SARS-CoV-2 in BALB/c mice
A) open reading frames (dark purple arrows) and proteins resulting from cleavage of ORF1ab polypeptide into non-structural proteins (light purple). 17 protein-coding mutations are annotated (top)
More from Billy Bostickson 🏴👁&👁 🆓
1. People's Justice Courts to be set up worldwide
2. Citizens' arrests of all Identified Suspects
3. Lab Inspections
3. Harsh interrogation using MKULTRA
4. Public Show Trials video streamed live
5. Cross Questioning of suspects via Twitter & Zoom
A growing list of suspects to be interrogated
Foul Traitors, Charlatans, Frauds, Bat Molesters! Frankensteins, Well Poisoners, Plotters, Deceivers!
Dr. Shipmans, Saboteurs, Devils in White Coats!
Organisations to be Investigated
Wuhan University IMA
Nanjing Military Lab
LAURIMA GOV SERVICES
Major General Chen Wei
Mr. Patrick, one of the chief scientists at the Army Biological Warfare Laboratories at Fort Detrick in Frederick, Md., held five classified US patents for the process of weaponizing anthrax.
Under Mr. Patrick’s direction, scientists at Fort Detrick developed a tularemia agent that, if disseminated by airplane, could cause casualties & sickness over 1000s mi². In a 10,000 mi² range, it had 90% casualty rate & 50% fatality rate
3/x His team explored Q fever, plague, & Venezuelan equine encephalitis, testing more than 20 anthrax strains to discern most lethal variety. Fort Detrick scientists used aerosol spray systems inside fountain pens, walking sticks, light bulbs, & even in 1953 Mercury exhaust pipes
4/x After retiring in 1986, Mr. Patrick remained one of the world’s foremost specialists on biological warfare & was a consultant to the CIA, FBI, & US military. He debriefed Soviet defector Ken Alibek, the deputy chief of the Soviet biowarfare program
5/x Back in Time
In 1949 the Army created a small team of chemists at "Camp Detrick" called Special Operations Division. Its assignment was to find military uses for toxic bacteria. The coercive use of toxins was a new field, which fascinated Allen Dulles, later head of the CIA
“The Origins of SARS-CoV-2: A Critical Review"
have just been published here:
by members of DRASTIC & others
@angoffinet @BahulikarRahul @MonaRahalkar @gdemaneuf
2. A refreshing contrast to the so-called "expert reactions" found here, including from one of the authors of the review (Prof David Robertson)!
"expert reaction to a preprint reviewing the evidence on the origins of SARS-CoV-2"
3. Peter Gutierrez points out in his response that 4 of the authors of “The Origins of SARS-CoV-2: A Critical Review”, also wrote “Proximal Origin of SARS-COV-2”.
His critique focuses on:
2. Enhanced adaptation to the human host
4. As to be expected, Sydney University and its iconic virologist, Eddie Holmes, who is "not available for interview", are crowing over this biased review
This review contains elementary errors as exposed here:
one of the authors (Stuart Neil) then claimed
"Didn’t N501Y come up in ACE2 TG mice too?
All your natural origin friends in one place ;)— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) July 7, 2021
Origins of SARS-CoV-2: A Critical Reviewhttps://t.co/j4A4rtmi8S
Fallacy of the "straw mouse", denying evolution in wild type mice, when the claim is actually that it may have "evolved" in hACE2 mice, NOT wild mice. pic.twitter.com/7LCnSAhw6g
Laulima Government Services (Fort Detrick BSL4) Contractor
(Alaka`ina Foundation) Hawaii DOD
Took over contract from Battelle
Tunnell Government Services
Jens Kuhn jumped ship from Battelle to steal
3/4 Jens Kuhn
wrote 6 tedious taxonomy papers with Fouchier
Farzan & Kuhn ACE-2 &
4/4 Animal Origins of SARS Cov:
Insight from ACE2-S-Protein Interactions
insights gained from study of SARS-CoV spike protein, which mediates viral entry & interaction with ACE2 receptor for SARS-CoV
Fang Li, Jens H. Kuhn, Michael Farzan
Global RNA Virome
S proteins of HCOVNL63 & SARS bind ACE 2 (with Farzan) https://t.co/K3RuTBo6R6!
Chapters 21, 22, 23 https://t.co/ckugrvRFwv
Chapter 57 in 1500 Page Book (Clinical Virology)
Pangolins, September 2019 and PLA are the key to this mystery
Meet Yang Ruifu, CCP's biological weapons expert https://t.co/JjB9TLEO95 via @Gnews202064— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) October 11, 2020
Interesting expose of China's top bioweapons expert who oversaw fake pangolin research
Paper 1: https://t.co/TrXESKLYmJ
2. A jacobin capuchin dangling a flagellin pangolin on a javelin while playing a mandolin and strangling a mannequin on a paladin's palanquin, said Saladin
More to come tomorrow!
3. Yigang Tong
4. YT Interview
Some bats & pangolins carry viruses related with SARS-CoV-2, found in SE Asia and in Yunnan, & the pangolins carrying SARS-CoV-2 related viruses were smuggled from SE Asia, so there is a possibility that SARS-CoV-2 were coming from
More from All
Mostly will work on Monday to Wednesday. Sometimes on Friday.
Why to pay your money to learn this if u can get it here.
U need only practice.
Say bank nifty future is at 32000.
Sell both 32000 call and put.
Considering current volatile market lest say premium on Monday morning is 350 on both sides.
Sold with 700 points combine premium.
If bank nifty will trade in narrow range say +\- 100 hold it.
If moving 200 points
then exit previous sold straddle. Sell new one. Let’s say BN moved +200
Now sell 32200. If bank nifty will move here within range then u will get profit through theta decay. Follow same procedure for next 150-200 pts move.
This is only for single straddle sell position.
Now in second case sell three straddle. 31900/32000/32100
In case of 100 points move no need to change.
If 200 + then future is 32200.
Exit 31900 and sell 31200 straddle.
If moving another 100 then exit 32000 and sell 32300. Continue same with 100 points move.
If no move then
it will consolidate between 32000-32200 or 32100 to 32300 and u will get theta decay.
This is for normal move. Sudden big move may come anytime. So keep SL in system.
If u r selling at 350-350 then keep SL in system 475 for both legs.
Practice it. No need to attend webinar.
Mangottu Bhagavathi Temple is situated in Athipotta near Alathur of palakkad district. Devi is kshipraprasadi here and grants relief to those who worship with full faith.
Mookken Chathen, situated on the Northern 👇
side of the temple, is guarding Devi here.
Story says that, once there lived a weaver named Kuttan who was a Devi Bhaktan. During one festival time Kuttan was so pleased by the Devi Vigraham that he requested her to come along with him. At that time wind blew heavily and Cloths
in Vigraham flew. Kuttan immediately decorated Devi with his cloth which stuck to Vigraham and returned to his village and with his Umbrella. Devi came with him in that Umbrella and stayed in his place. This place is Mangottu Bhagavathi temple now.
If I had 1 hour per day (for non-Company related research), this is what I would do.
Going thru specific topics on specific days should help streamline the reading/learning process w/o causing too much information overload.
Investing in individual stocks is more than just company specific research.
It's about having a broader perspective on many topics including Investing principles/philosophy/history, Industry trends/landscapes, and thoughts/deep dives from other reliable sources.
I'm grateful to all these awesome folks that put out such quality content.
Also separate h/t to all the folks I follow on Twitter (list always growing, albeit slowly). You posts diversify and enrich my feed & learning.
Below thread has the resources listed by topic (and not by calendar days).
The below is NOT a ranking of resources. Just a listing of my current fav resources based on specific topics.
Descriptions on why I like each resource is not listed here (due to the huge #). You can find that info for most of these resources in my current pinned tweet.
Like all skills this can be learned.
Here's what makes for a good Mains answer
= Thread =
Before we start, these are borrowed ideas.
• Gaurav Agarwal @crazyphoton (Rank 1, CSE2013)
• Anudeep Durishetty @anudeepd7 (Rank 1, CSE2017)
• Pratyush Pandey (Rank 21, CSE2019)
Even Pratyush and Anudeep mention @crazyphoton as the OG.
Your answer needs to have structure.
This makes it easier to read, and ensures that you have covered all parts of the question asked.
Let's look at what makes for good structure.
Keep it simple.
Choose one word from the question and define it.
Quote facts or relevant articles if possible.
This one line about the topic let's the examiner know you've understood the question.
Break it into 3 parts:
• Context - what has happened so far
• Main argument
• Counter argument
Give counter arguments (one line works) even when not asked. This adds another angle to your answer.
UPSC is looking for breadth, not depth.
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When Saudi Arabia's King visited India in 1955, PM Nehru ordered all the Hindu Temples and Idols of Hindu Deities that came in Saudi King's way to be covered up.
Our temples are the architectural marvels in their own league.
Each of our temples tells the story of our rich history and cultural heritage. Was Nehru that ashamed of his own nation's heritage that he had to cover them up or there was some other reason? The answer would be best known to him only.
PM Nehru invited the then Saudi King Saud bin Abdul Aziz to India who accepted the invitation and planned a 17 day long official visit to India in 1955. Saudi King had brought a large delegation with him and he had to visit various Indian cities like Mumbai, Hyderabad, Agra,
Aligarh, Shimla, Mysore and Varanasi. However, when Saudi King reached Varanasi, Nehru ordered to cover all the temples and Idols with curtains that came in the way of the Royal Convoy. During his stay in Varanasi, Govt buildings were painted with the words "Kalma Tayyiba".
'Kalma Tayyiba' means 'There is not God but only Allah and Mohammed is his messenger'. In addition to it, Pooja and Aartis were also stopped at temples. I can call it the appeasement politics of the highest order and Nehru was indeed the greatest appeaser of all times.
Kolejny raz Danił Kwiat miał pracowitą noc w symulatorze i zebrane dane wskazały, że stary pakiet pracuje wydajniej. #F1pl
Stary pakiet bardzo dobrze obchodził się z oponami. Jeśli mamy gdzieś szukać plusów, to chyba właśnie tam. Wysoka temperatura może im dziś sprzyjać. #F1pl
Can we build a better chatbot using this control?
And what makes a good conversation anyway?
Check out the blog post for our NAACL paper:
#AI #NLProc #DeepLearning #ConversationalAI @facebookai
This post got a little delayed since the paper's publication, but the intervening time has given me an opportunity to reflect.
So this post has some extra thoughts regarding more recent NLG developments - e.g., pretrained models like GPT(2), and the suitability of beam search.
65.2% of Republicans think that people shouldn't be so easily offended... AND that Black Lives Matter is offensive. https://t.co/znmVhqIaL8
64.6% of Democrats think that a woman has the right to do what she wants with her body... AND that selling organs should be illegal.
48.5% of Democrats think that a woman has the right to do what she wants with her body... AND that prostitution should be illegal.
57.9% of Republicans think that people should be free to express their opinions in the workplace... AND that athletes should not be allowed to sit or kneel during the national anthem. https://t.co/ds2ig1NJFr
Democrats: Men and women are equal in their talents and abilities. Also, women are superior. https://t.co/bEFSmqQguo
Made by James Howard Kunstler
Kunstler is said to be one of the best thinkers and authors of our modern era. He’s well known as an expert in energy economics, among other topics.
He is NOT a fan of Trump which makes his predictions even more interesting.
1) The election is re-adjudicated, fraud subtracted from the tally, and President Trump is declared the winner.
2) The mail-in vote for the Georgia Senate seat runoff is disqualified as systematic fraud is revealed. Stacy Abrams is indicted for organizing the fraud.
3) A number of political celebrities, DC swamp rats, K-Street hustlers, media figures, and tech company executives are arrested and charged with serious crimes around election fraud.
4) The CIA is purged and reduced to a strictly analytical role for advising the executive.