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Saved by @BillyBostickson

@NBA @StephenKissler @yhgrad B.1.1.7 reveals clearly that SARS-CoV-2 is reverting to its original pre-outbreak condition, i.e. adapted to transgenic hACE2 mice (either Baric's BALB/c ones or others used at WIV labs during chimeric bat coronavirus experiments aimed at developing a pan betacoronavirus vaccine)

 @EricTopol @NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice https://t.co/TNE4tuLkqN
@EricTopol @NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2 https://t.co/B3eR764c1Z
@EricTopol @NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj
@EricTopol @NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
@EricTopol @NBA @StephenKissler @yhgrad Mice!
A mink-associated variant carrying Δ(69-70)-Y453F-F486L-N501T-M1229I mutations was also able to utilize mouse Ace2. In addition, all variants carrying an N501Y mutation, a shared feature of UK, South Africa, & Brazil VOC strains, efficiently use mouse Ace2 orthologs.
@EricTopol @NBA @StephenKissler @yhgrad Topolino!
"Moreover, the K417N-E484K-N501Y mutations found in the South Africa variant 501Y.V2 even enable the virus to utilize rat Ace2 more efficiently than using human ACE2. These data suggest that rats and mice may (have) be(en) able to harbor and spread these variants"?
@EricTopol @NBA @StephenKissler @yhgrad Above taken from:
Circulating SARS-CoV-2 variants B.1.1.7, 501Y.V2, and P.1 have gained ability to utilize rat and mouse Ace2 and altered in vitro sensitivity to neutralizing antibodies and ACE2-Ig
https://t.co/j9qEcUz4ea
Well worth a read!
@EricTopol @NBA @StephenKissler @yhgrad even the mink variants were mouse ACE2 adapted, what a surprise...now, who would have expected that?
@EricTopol @NBA @StephenKissler @yhgrad Serial passaging of virus in mouse lungs results in adaptive mutations that increase viral infectivity
MASCp6 genome contains 5 mutations compared to its parental strain IME-BJ05, resulting in four amino acid residue changes in the ORF1ab, S, and N genes, respectively (Fig. 3A)
@EricTopol @NBA @StephenKissler @yhgrad The N501Y mutation seems to provide a more favorable interaction with mouse ACE2 for docking and entry, thus leading to the increased virulence phenotype in mice.
Adaptation of SARS-CoV-2 in BALB/c mice
https://t.co/I90OOCJg7o
@EricTopol @NBA @StephenKissler @yhgrad Protein-coding mutations in SARS-CoV-2 B.1.1.7 virus variant.
A) open reading frames (dark purple arrows) and proteins resulting from cleavage of ORF1ab polypeptide into non-structural proteins (light purple). 17 protein-coding mutations are annotated (top)
@EricTopol @NBA @StephenKissler @yhgrad which includes 14 non-synonymous mutations and 3 deletions spanning 5 viral proteins. B) Expansion of the genomic region from spike to N protein for visualization purposes.
@EricTopol @NBA @StephenKissler @yhgrad "N501Y mutation in SARS-CoV-2 spike leads to morbidity in obese and aged mice"
https://t.co/FOfZg8SiQU
@EricTopol @NBA @StephenKissler @yhgrad Differential efficiencies to neutralize the novel mutants B.1.1.7 and 501Y.V2 by collected sera from convalescent COVID-19 patients and RBD nanoparticle-vaccinated rhesus macaques
https://t.co/fBHaTllKvJ
@EricTopol @NBA @StephenKissler @yhgrad Just to annoy people
Virology: the problem with ‘leaky’ vaccines
Fresh evidence supports the theory that some vaccines lead to the evolution of more virulent viral strains
https://t.co/ttyM9J2idI

More from Billy Bostickson 🏴👁&👁 🆓

Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
!. Simple Sabotage Tips
Unhappy with Everyday Life?
Frothing at the Mouth against oppressive bureaucracy?
Sick of petty tyrants and tin pot dictators?
Tormented by intrusive modern technology?
Feel like "sticking it to the man"?


2. The following is taken from sections 11,12 of the OSS's Simple Sabotage Field Manual, a 1944 document that has been declassified. The OSS became the CIA after WWII. The full document is

3. (a) Organizations and Conferences
Insist on doing everything through "channels." Never permit short-cuts to be taken in order to, expedite decisions.

4. Make "speeches." Talk as frequently as possible and at great length. Illustrate your "points" by long anecdotes and accounts of personal experiences.
Never hesitate to make a few appropriate "patriotic" comments.

5. When possible, refer all matters to committees, for "further study & consideration"
make the committees as large as possible - never less than 5
- Bring up irrelevant issues as frequently as possible
- Haggle over precise wordings of communications, minutes, resolutions
LIFE
Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
An "Aquarium" needs cleaning in my opinion, but who am I, a mere monkey, to give advice?
Astonished at what @bellingcat discovered about GRU & FSB operations
Skripal https://t.co/PzH3a7JZvy
Navalny https://t.co/eZi63UhWw1
FSB https://t.co/sViYk9RwmB
GRU https://t.co/MY5d5gw2OG


A great post by Ilya Yahin on

Every time Putin talks about “our special services,” his signature smirk appears on his face, and in his words there is poorly concealed bragging
"Of course, we knew everything in advance"
"Yes, we are looking"
"Mercader has already been sent"
“World-class professionals”

Putin clearly loves all these spy games. He is very proud of the special services and therefore endlessly increases budget funding for them.
This is his top priority.
The elderly dictator cannot understand one thing:

there are no effective special services in a state that is completely corroded by corruption. You won't have honest professionals at your fingertips if your son-in-law buys shares of a state company for $ 100, the real value of which exceeds $ 380 million.
ALL , BUSINESS
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Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
@jimmy_wales Thanks for replying!
1/. I will make a thread here with some details so you can see for yourself how a small clique of pro Chinese gatekeeping editors and admins have bullied editors, throttled dissent and gamed the system to impose their POV.

2/. I am a supporter of


3/. This is what I ended up feeling about WP after


4/. Some disturbing


5./ Some members of the gatekeeping
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Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
1. Omicron Thread - A Compilation of Opinions

"finally, the time has slip and slid its slimy course through to us - and we're the vicious bastards of the new generation. we do not relent, and we should not be held to account for our ancestral faults"

https://t.co/mhJO6yOQRE


2. The Letter Chosen by the WHO

"It's amazing that the Xi variant seems to have somehow managed to evade detection..."

via @readomain

Why 'Omicron', Not 'Nu' or 'Xi'?

WHO Says Two Letters in Greek Alphabet Jumped to 'Avoid Stigma'

https://t.co/xnGR9XK2tF


3. The Omicron variant has been found in nearly every province of South Africa, as well as Botswana, Belgium, Israel, UK and Hong Kong.

This month, Israel held an exercise, The “Omega Exercise”, meant to prepare for a hypothetical, new COVID-19

4. Omicron Infographic

(appeared in Germany and Italy now)

https://t.co/oNFYBH1F1o


5. Overview of Omicron (B.1.1.529) from @nicd_sa

https://t.co/HN9csJqK0z
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Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193
Billy Bostickson 🏴👁&👁 ...
@BillyBostickson
Tactics & Direct Action are necessary against Tyrants

"Guerrilla tactics used against the military include assassinations of its officials, bombing military property and sabotaging infrastructure such as telecom towers and

Dr Sasa, spokesperson for the exiled opposition National Unity Government (NUG), said the public had no choice but to defend itself:

"The military are not only destroying our democracy and freedom, but they are destroying every day our dignity as human beings"

It’s do or die”

The residence of coup leader Min Aung Hlaing is a testament to his ambition—and his fear of the people he seeks to rule

https://t.co/yInq583gI5


Apart from Mansion 1, which serves as his official residence, Min Aung Hlaing is known to have several other homes. One is the Yarzathingaha residence in Naypyitaw’s Ottarathiri Township & another is at No.14 Inya Road in Yangon, also properties in Pyin Oo Lwin.


As Myanmar’s most powerful family accumulates vast wealth through military-linked companies like Mytel, the country’s poverty rate will double by next year due to the combined impact of Covid-19 pandemic & the coup.

Nearly half of Myanmar will be living in absolute poverty
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More from All

Devdutta
Devdutta
@Devdutta96
Please please please take your cyber security seriously even if you don’t consider yourself a high risk person. Here are a few easy things to start with. 1/n

Switch from WhatsApp to Signal and enable disappearing messages. Most of us cannot stop using WhatsApp entirely but at least turn off back ups to Google Drive or iCloud. 2/n

Do not have private conversations using the messaging service on any social media platform like Facebook, Instagram or Twitter. 3/n

Switch from Gmail to ProtonMail or any other secure email service provider. 4/n


Switch from Google Docs to CryptPad or RiseUp Pad.
CYBER SECURITY , IT PRIVACY , CYBER SECURITY STEPS
Mitesh Patel
Mitesh Patel
@Mitesh_Engr
Again sharing bank nifty intraday weekly straddle. How to play by selling straddle.
Mostly will work on Monday to Wednesday. Sometimes on Friday.
Why to pay your money to learn this if u can get it here.
U need only practice.
Let’s go.

Say bank nifty future is at 32000.
Sell both 32000 call and put.
Considering current volatile market lest say premium on Monday morning is 350 on both sides.
Sold with 700 points combine premium.
If bank nifty will trade in narrow range say +\- 100 hold it.
If moving 200 points

then exit previous sold straddle. Sell new one. Let’s say BN moved +200
Now sell 32200. If bank nifty will move here within range then u will get profit through theta decay. Follow same procedure for next 150-200 pts move.

This is only for single straddle sell position.

Now in second case sell three straddle. 31900/32000/32100
In case of 100 points move no need to change.
If 200 + then future is 32200.
Exit 31900 and sell 31200 straddle.
If moving another 100 then exit 32000 and sell 32300. Continue same with 100 points move.
If no move then

it will consolidate between 32000-32200 or 32100 to 32300 and u will get theta decay.

This is for normal move. Sudden big move may come anytime. So keep SL in system.
If u r selling at 350-350 then keep SL in system 475 for both legs.
Practice it. No need to attend webinar.
BNF , MPATELOPTIONSLEARNINGS , OPTIONSLEARNING
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Jaya_Upadhyaya
Jaya_Upadhyaya
@Jayalko1
WEAPONS OF MAHADEV

Sarvaripati Shiva is one of the most fearsome manifestations of Mahadev. Assigned with destroying all of the universes at the end of time, Shiva is one of the most fearsome warriors. He is the Mrityunjaya.
Here are some weapons associated with him:


TRISHULA: the 3 pointed blades denote creation, maintenance, and destruction or the 3 Kalas – Past, Present and Future. They also represent 3 Gunas – Sattva, Rajas and Tamas).
Shiva’s trishul can only be stopped by Shiva himself.
@onlyonenetra @DetheEsha


Trishul is also said to represent Ida, Pingala, and Sushumna. These are the three basic nadis – the left, the right and the central – in the pranamaya kosha, or the energy body of the human system.
@iamkamyabuch @unever_followme


PARASHU: axe with 4 cutting edges which Shiva gave to Parashurama. In his anger, Parashurama used the parashu to get rid of the all the Earth’s tyrannical kshatriya caste twenty-one times over.
@harshasherni


CHANDRAHASA SWORD: The divine sword Chandrahasa literally means ‘the laughter of the moon’. Ravana gave this sword to Indrajit on different occasions especially to fight against Devas.
GIRISH: A special sword of Shiva with unique characteristics.
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Sachin Ramje
Sachin Ramje
@SachinRamje
10 must-read books to transform your workday and boost productivity:


1. Atomic Habits


2. The Power of Habit


3. Deep Work


4. Essentialism
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Angela Jamison
Angela Jamison
@AnJamison
@SethAbramson @buzz\_chronicles @buzz\\\_chronicles @buzz_chronicles save as category @pdfmakerapp grab @pdfmakerapp grab this @readwiseio save @readwiseio save thread @threader compile summarize @Threadreaderapp unroll please @ttttreads unroll @unrollthread.com @SaveToBookmarks
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Conviction | Patience
Conviction | Patience
@unseenvalue
H was always unseen in S2NL :)

Those who exited at 1500 needed money. They can always come back near 969. Those who exited at 230 also needed money. They can come back near 95.

Those who sold L @ 660 can always come back at 360. Those who sold S last week can be back @ 301
UVLEARNINGS
Vibhu Vashisth
Vibhu Vashisth
@VIBHU_Tweet
🌺श्री गरुड़ पुराण - संक्षिप्त वर्णन🌺

हिन्दु धर्म के 18 पुराणों में से एक गरुड़ पुराण का हिन्दु धर्म में बड़ा महत्व है। गरुड़ पुराण में मृत्यु के बाद सद्गती की व्याख्या मिलती है। इस पुराण के अधिष्ठातृ देव भगवान विष्णु हैं, इसलिए ये वैष्णव पुराण है।


गरुड़ पुराण के अनुसार हमारे कर्मों का फल हमें हमारे जीवन-काल में तो मिलता ही है परंतु मृत्यु के बाद भी अच्छे बुरे कार्यों का उनके अनुसार फल मिलता है। इस कारण इस पुराण में निहित ज्ञान को प्राप्त करने के लिए घर के किसी सदस्य की मृत्यु के बाद का समय निर्धारित किया गया है...

..ताकि उस समय हम जीवन-मरण से जुड़े सभी सत्य जान सकें और मृत्यु के कारण बिछडने वाले सदस्य का दुख कम हो सके।
गरुड़ पुराण में विष्णु की भक्ति व अवतारों का विस्तार से उसी प्रकार वर्णन मिलता है जिस प्रकार भगवत पुराण में।आरम्भ में मनु से सृष्टि की उत्पत्ति,ध्रुव चरित्र की कथा मिलती है।


तदुपरांत सुर्य व चंद्र ग्रहों के मंत्र, शिव-पार्वती मंत्र,इन्द्र सम्बंधित मंत्र,सरस्वती मंत्र और नौ शक्तियों के बारे में विस्तार से बताया गया है।
इस पुराण में उन्नीस हज़ार श्लोक बताए जाते हैं और इसे दो भागों में कहा जाता है।
प्रथम भाग में विष्णुभक्ति और पूजा विधियों का उल्लेख है।

मृत्यु के उपरांत गरुड़ पुराण के श्रवण का प्रावधान है ।
पुराण के द्वितीय भाग में 'प्रेतकल्प' का विस्तार से वर्णन और नरकों में जीव के पड़ने का वृत्तांत मिलता है। मरने के बाद मनुष्य की क्या गति होती है, उसका किस प्रकार की योनियों में जन्म होता है, प्रेत योनि से मुक्ति के उपाय...
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Vibhu Vashisth
Vibhu Vashisth
@VIBHU_Tweet
ANCIENT BHARAT WAS CALLED VISHWAGURU, AND IT REALLY DESERVED IT.

India had a well developed education system centuries before the westerners arrived and called us uncivilized. Education was always given a great importance in Indian civilisation since times immemorial.


Ancient India had the Gurukulas and Ashramas as the epicentres of the knowledge and enlightenment. Bigger Gurukulas served as the centres of higher education called universities. Besides these universities, temples also emerged as the major learning centres.

Studying the Holy Scriptures, character building, personality development, responsibilities towards self,family and society,discipline and preservation of the ancient culture and heritage were the key embodiments of education.

This kind of education system made ancient India, a centre of knowledge all over the world. Many foreign students came to India for education and India was called the 'Vishwaguru'.
Takshshila and Nalanda were the two prominent universities of ancient India.


But were these only Universities of ancient India?The answer is 'No'.Let's learn about these gems of our education system that flourished across ancient India & be proud.

NALANDA UNIVERSITY
This was the oldest university of ancient India.Situated in Nalanda distt. of Bihar...
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Noah Smith
Noah Smith
@Noahpinion
Remember: Just because an idea is old doesn't mean it's good.

Knowing whether old ideas are more likely to be good requires understanding whether conditions have changed in important ways.

Horse archery was an amazing method of warfare for over a thousand years...then people invented guns, and suddenly this great idea that had stood the test of time became obsolete.

Then again, when underlying conditions don't change much, tried-and-true approaches are probably better.

"Learning the lessons of history" usually just means assuming ergodicity and stationarity in an informal time-series model...

(end)
SOCIETY
Jaya_Upadhyaya
Jaya_Upadhyaya
@Jayalko1
BANASHANKARI AMMA, NEAR BADAMI (KAR)
#bharatmandir #navratri2021

Originally built by Chalukyas in 7th century. Devi Banashankari was their family deity. This image of Banashankari Amma was installed by Jagadekamalla I in 630 AD.

Later renovations were done by Marathas.


Once, a demon Durgamasur was troubling the people of this area. Answering the prayers of Devas, Ma Parvati emerged from the yajna fire as Banashankari and killed Durgamasur.
This area has rich forests of coconut, betel nut and other trees.
@GunduHuDuGa


It is said that during a severe famine, Devi provided vegetables and fruits to the people of this area.
Hence, she is also worshipped here as Shakambhari.
In the annual festival called Banashankari jatre, a Rath yatra takes place and Devi moves around the city in the chariot.
ALL