1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 30, 2021
"we generated a mouse model expressing hACE2 by using CRISPR/Cas9 knockin technology. In comparison with wild-type C57BL/6 mice, both young & aged hACE2 mice sustained high viral loads... pic.twitter.com/j94XtSkscj
@NBA @StephenKissler @yhgrad B.1.1.7 reveals clearly that SARS-CoV-2 is reverting to its original pre-outbreak condition, i.e. adapted to transgenic hACE2 mice (either Baric's BALB/c ones or others used at WIV labs during chimeric bat coronavirus experiments aimed at developing a pan betacoronavirus vaccine)
1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 2, 2021
2 papers:
Human\u2013viral molecular mimicryhttps://t.co/irfH0Zgrve
Molecular Mimicryhttps://t.co/yLQoUtfS6s https://t.co/lsCv2iMEQz
https://t.co/9Z4oJmkcKj
https://t.co/I90OOCJg7o
A mink-associated variant carrying Δ(69-70)-Y453F-F486L-N501T-M1229I mutations was also able to utilize mouse Ace2. In addition, all variants carrying an N501Y mutation, a shared feature of UK, South Africa, & Brazil VOC strains, efficiently use mouse Ace2 orthologs.
"Moreover, the K417N-E484K-N501Y mutations found in the South Africa variant 501Y.V2 even enable the virus to utilize rat Ace2 more efficiently than using human ACE2. These data suggest that rats and mice may (have) be(en) able to harbor and spread these variants"?
Circulating SARS-CoV-2 variants B.1.1.7, 501Y.V2, and P.1 have gained ability to utilize rat and mouse Ace2 and altered in vitro sensitivity to neutralizing antibodies and ACE2-Ig
https://t.co/j9qEcUz4ea
Well worth a read!
MASCp6 genome contains 5 mutations compared to its parental strain IME-BJ05, resulting in four amino acid residue changes in the ORF1ab, S, and N genes, respectively (Fig. 3A)
Adaptation of SARS-CoV-2 in BALB/c mice
https://t.co/I90OOCJg7o
A) open reading frames (dark purple arrows) and proteins resulting from cleavage of ORF1ab polypeptide into non-structural proteins (light purple). 17 protein-coding mutations are annotated (top)
https://t.co/FOfZg8SiQU
https://t.co/fBHaTllKvJ
Virology: the problem with ‘leaky’ vaccines
Fresh evidence supports the theory that some vaccines lead to the evolution of more virulent viral strains
https://t.co/ttyM9J2idI
More from Billy Bostickson 🏴👁&👁 🆓
1/X Bellagio Rockefeller Initiative (Global Virome Project)
Another look at some key people in the GVP & their media statements since January 2020 about "natural origin" and impossibility of a "lab leak"
Full List of 18 scientists in photograph is here:
https://t.co/yHoAjwQjI8
2/X
We have already looked closely at Dennis Carroll, Peter Daszak, George Gao, W. Ian Lipkin & seen their public statements supporting "natural origin" & hysterical attacks on "lab leak" theories.
This thread focuses on:
Michael Kurilla
Jonna Mazet
Edward Rubin (Metabiota)
3/X
If we look at the leadership team of GVP, you will see some familiar faces:
https://t.co/WdT8sNnfmy
Most familiar is probably Peter Daszak, the wealthy Treasurer, also with the key role of Secretary.
Note: USAID PREDICT Project - EcoHealthAlliance
4/X
The "Chair" is Dr. Dennis Carroll
We will have a look at his media statements on the coronavirus pandemic by inputting his name in Twitter search box (very easy!)
Note: Previously was Director of USAID Emerging Pandemic Threats Program
5/X Dennis Carroll's video media statements (1):
CNN
(note Qinghai Thangka positioned in background which Daszak also shows off in his videos obtained during EcoHealth virus hunt with
Another look at some key people in the GVP & their media statements since January 2020 about "natural origin" and impossibility of a "lab leak"
Full List of 18 scientists in photograph is here:
https://t.co/yHoAjwQjI8
2/X
We have already looked closely at Dennis Carroll, Peter Daszak, George Gao, W. Ian Lipkin & seen their public statements supporting "natural origin" & hysterical attacks on "lab leak" theories.
This thread focuses on:
Michael Kurilla
Jonna Mazet
Edward Rubin (Metabiota)
3/X
If we look at the leadership team of GVP, you will see some familiar faces:
https://t.co/WdT8sNnfmy
Most familiar is probably Peter Daszak, the wealthy Treasurer, also with the key role of Secretary.
Note: USAID PREDICT Project - EcoHealthAlliance
4/X
The "Chair" is Dr. Dennis Carroll
We will have a look at his media statements on the coronavirus pandemic by inputting his name in Twitter search box (very easy!)
Note: Previously was Director of USAID Emerging Pandemic Threats Program
5/X Dennis Carroll's video media statements (1):
CNN
(note Qinghai Thangka positioned in background which Daszak also shows off in his videos obtained during EcoHealth virus hunt with
Warnings ignored, and the stunning fact that the wealthiest country in the world is short of masks and gowns and ventilators - and possibly, hospital beds. Dr Dennis Carroll says it's time to rip off the bandaid on harsh #coronavirus\xa0measures. #COVID19 pic.twitter.com/ZNZnhZnmPs
— Michael Holmes (@holmescnn) March 21, 2020
1. Omicron Thread - A Compilation of Opinions
"finally, the time has slip and slid its slimy course through to us - and we're the vicious bastards of the new generation. we do not relent, and we should not be held to account for our ancestral faults"
https://t.co/mhJO6yOQRE
2. The Letter Chosen by the WHO
"It's amazing that the Xi variant seems to have somehow managed to evade detection..."
via @readomain
Why 'Omicron', Not 'Nu' or 'Xi'?
WHO Says Two Letters in Greek Alphabet Jumped to 'Avoid Stigma'
https://t.co/xnGR9XK2tF
3. The Omicron variant has been found in nearly every province of South Africa, as well as Botswana, Belgium, Israel, UK and Hong Kong.
This month, Israel held an exercise, The “Omega Exercise”, meant to prepare for a hypothetical, new COVID-19
4. Omicron Infographic
(appeared in Germany and Italy now)
https://t.co/oNFYBH1F1o
5. Overview of Omicron (B.1.1.529) from @nicd_sa
https://t.co/HN9csJqK0z
"finally, the time has slip and slid its slimy course through to us - and we're the vicious bastards of the new generation. we do not relent, and we should not be held to account for our ancestral faults"
https://t.co/mhJO6yOQRE
Here is how B.1.1.529 (#Omicron #B11529) compares to Alpha, Beta, Gamma, Delta variants.
— nference (@_nference) November 27, 2021
Omicron has highest novel Spike mutations including striking cluster on the "crown" suggesting significant selection pressure & antigenic distinction from prior strains
(Credits: nference) pic.twitter.com/4oZQbjhbG8
2. The Letter Chosen by the WHO
"It's amazing that the Xi variant seems to have somehow managed to evade detection..."
via @readomain
Why 'Omicron', Not 'Nu' or 'Xi'?
WHO Says Two Letters in Greek Alphabet Jumped to 'Avoid Stigma'
https://t.co/xnGR9XK2tF
3. The Omicron variant has been found in nearly every province of South Africa, as well as Botswana, Belgium, Israel, UK and Hong Kong.
This month, Israel held an exercise, The “Omega Exercise”, meant to prepare for a hypothetical, new COVID-19
4. Omicron Infographic
(appeared in Germany and Italy now)
https://t.co/oNFYBH1F1o
5. Overview of Omicron (B.1.1.529) from @nicd_sa
https://t.co/HN9csJqK0z
Prof @Tuliodna is giving an insightful overview of the #NewVariant #B11529 pic.twitter.com/VnFBrj2pOT
— NICD (@nicd_sa) November 25, 2021
Tactics & Direct Action are necessary against Tyrants
"Guerrilla tactics used against the military include assassinations of its officials, bombing military property and sabotaging infrastructure such as telecom towers and
Dr Sasa, spokesperson for the exiled opposition National Unity Government (NUG), said the public had no choice but to defend itself:
"The military are not only destroying our democracy and freedom, but they are destroying every day our dignity as human beings"
It’s do or die”
The residence of coup leader Min Aung Hlaing is a testament to his ambition—and his fear of the people he seeks to rule
https://t.co/yInq583gI5
Apart from Mansion 1, which serves as his official residence, Min Aung Hlaing is known to have several other homes. One is the Yarzathingaha residence in Naypyitaw’s Ottarathiri Township & another is at No.14 Inya Road in Yangon, also properties in Pyin Oo Lwin.
As Myanmar’s most powerful family accumulates vast wealth through military-linked companies like Mytel, the country’s poverty rate will double by next year due to the combined impact of Covid-19 pandemic & the coup.
Nearly half of Myanmar will be living in absolute poverty
"Guerrilla tactics used against the military include assassinations of its officials, bombing military property and sabotaging infrastructure such as telecom towers and
Dr Sasa, spokesperson for the exiled opposition National Unity Government (NUG), said the public had no choice but to defend itself:
"The military are not only destroying our democracy and freedom, but they are destroying every day our dignity as human beings"
It’s do or die”
The residence of coup leader Min Aung Hlaing is a testament to his ambition—and his fear of the people he seeks to rule
https://t.co/yInq583gI5
Apart from Mansion 1, which serves as his official residence, Min Aung Hlaing is known to have several other homes. One is the Yarzathingaha residence in Naypyitaw’s Ottarathiri Township & another is at No.14 Inya Road in Yangon, also properties in Pyin Oo Lwin.
As Myanmar’s most powerful family accumulates vast wealth through military-linked companies like Mytel, the country’s poverty rate will double by next year due to the combined impact of Covid-19 pandemic & the coup.
Nearly half of Myanmar will be living in absolute poverty
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"I lied about my basic beliefs in order to keep a prestigious job. Now that it will be zero-cost to me, I have a few things to say."
We know that elite institutions like the one Flier was in (partial) charge of rely on irrelevant status markers like private school education, whiteness, legacy, and ability to charm an old white guy at an interview.
Harvard's discriminatory policies are becoming increasingly well known, across the political spectrum (see, e.g., the recent lawsuit on discrimination against East Asian applications.)
It's refreshing to hear a senior administrator admits to personally opposing policies that attempt to remedy these basic flaws. These are flaws that harm his institution's ability to do cutting-edge research and to serve the public.
Harvard is being eclipsed by institutions that have different ideas about how to run a 21st Century institution. Stanford, for one; the UC system; the "public Ivys".
As a dean of a major academic institution, I could not have said this. But I will now. Requiring such statements in applications for appointments and promotions is an affront to academic freedom, and diminishes the true value of diversity, equity of inclusion by trivializing it. https://t.co/NfcI5VLODi
— Jeffrey Flier (@jflier) November 10, 2018
We know that elite institutions like the one Flier was in (partial) charge of rely on irrelevant status markers like private school education, whiteness, legacy, and ability to charm an old white guy at an interview.
Harvard's discriminatory policies are becoming increasingly well known, across the political spectrum (see, e.g., the recent lawsuit on discrimination against East Asian applications.)
It's refreshing to hear a senior administrator admits to personally opposing policies that attempt to remedy these basic flaws. These are flaws that harm his institution's ability to do cutting-edge research and to serve the public.
Harvard is being eclipsed by institutions that have different ideas about how to run a 21st Century institution. Stanford, for one; the UC system; the "public Ivys".