Craig, M. C., et al (2007). Gonadotropin hormone releasing hormone agonists alter prefrontal function during verbal encoding in young women. Psychoneuroendocrinology, 32(8-10), 1116–1127.

I will link this back to the original thread, but it is better for Clarity and to stop any gaming of Twitter and the creation of any labyrinth where details get lost to be avoided.

This 2007 paper identifies issues with GnRHa usage and Executive Function.
As memory is affected, especially the formation of NEW memories for new information, and the implications that subjects are not able to grasp and utilise new information needed for "Informed Consent", impacts upon Executive Function are evident.
Using Google Scholar as a quick and dirty source, we find that the paper and evidence is cited in at least 51 other papers since 2007.

https://t.co/conx3aVm3N
The breadth of concerns raised is interesting.

The implications of the Contraceptive Pill on brain function and reduced executive function get raised. - A Sexed issue.
The issues raised in working memory and executive function for women undergoing treatment for Breast cancer with hormone-altering Drugs is featured.
Alterations in Emotional memory, Cognitive memory, short term memory and related executive functions due to menstrual cycle are featured.

Some will scream Reproducibility.... and miss that the same findings have been reproduced by many routes.
Changes in cognition, memory and executive function in premenopausal women and menopausal women feature.

It seems that to see the Executive Function issues one has to study the fluctuations identifiable in the Female Body but not the Male Body.
However, having found an issue of alterations to the hypothalamic–pituitary–adrenal axis in females, and how it is linked to GnRHas one can go and see if it has the same effects or different effects in males.

Is the Spike in Gender Dysporic females real or monthly?
Indicators are that the same loss of memory and executive function is present in Trans males but less pronounced.

My concern is that if someone like me can read and grasp the patterns, why did GIDS, the experts, not see the issues?
@threadreaderapp unroll

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Let's talk honestly about "informed consent."
Someone with decades of training gives someone with none advice usually packed into 1-3 mins. Huge amount is based on trust. Huge potential for bias built in. But also there is no obligation to provide real alternative options.


I am classified as 'gifted' (obnoxious and ableist term). I mention because of what I am about to say. You all know that I was an ambulatory wheelchair user previously - could stand - but contractures have ended that. When I pleaded for physio, turned down. But did you know...

I recently was chatting with a doctor I know and explaining what happened and the day the physiatrist told me it was too late and nothing could be done. The doctor asked if I'd like one of her friends/colleagues to give second opinion. I said yes please! So...

She said can you send me MRI and other imaging they did to determine it wasn't possible to address your contractures.

Me: What?
Dr.: They did a MRI first before deciding right?
Me: No
Dr: What did they do??!
Me: Examined me for 2 minutes.
Dr: I am very angry rn. Can't talk.

My point is you don't even know if you are making "informed" decisions because the only source of information you have is the person who has already decided what they think you should do. And may I remind you of a word called 'compliance.'

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A brief analysis and comparison of the CSS for Twitter's PWA vs Twitter's legacy desktop website. The difference is dramatic and I'll touch on some reasons why.

Legacy site *downloads* ~630 KB CSS per theme and writing direction.

6,769 rules
9,252 selectors
16.7k declarations
3,370 unique declarations
44 media queries
36 unique colors
50 unique background colors
46 unique font sizes
39 unique z-indices

https://t.co/qyl4Bt1i5x


PWA *incrementally generates* ~30 KB CSS that handles all themes and writing directions.

735 rules
740 selectors
757 declarations
730 unique declarations
0 media queries
11 unique colors
32 unique background colors
15 unique font sizes
7 unique z-indices

https://t.co/w7oNG5KUkJ


The legacy site's CSS is what happens when hundreds of people directly write CSS over many years. Specificity wars, redundancy, a house of cards that can't be fixed. The result is extremely inefficient and error-prone styling that punishes users and developers.

The PWA's CSS is generated on-demand by a JS framework that manages styles and outputs "atomic CSS". The framework can enforce strict constraints and perform optimisations, which is why the CSS is so much smaller and safer. Style conflicts and unbounded CSS growth are avoided.
1/“What would need to be true for you to….X”

Why is this the most powerful question you can ask when attempting to reach an agreement with another human being or organization?

A thread, co-written by @deanmbrody:


2/ First, “X” could be lots of things. Examples: What would need to be true for you to

- “Feel it's in our best interest for me to be CMO"
- “Feel that we’re in a good place as a company”
- “Feel that we’re on the same page”
- “Feel that we both got what we wanted from this deal

3/ Normally, we aren’t that direct. Example from startup/VC land:

Founders leave VC meetings thinking that every VC will invest, but they rarely do.

Worse over, the founders don’t know what they need to do in order to be fundable.

4/ So why should you ask the magic Q?

To get clarity.

You want to know where you stand, and what it takes to get what you want in a way that also gets them what they want.

It also holds them (mentally) accountable once the thing they need becomes true.

5/ Staying in the context of soliciting investors, the question is “what would need to be true for you to want to invest (or partner with us on this journey, etc)?”

Multiple responses to this question are likely to deliver a positive result.