BC GOVERNMENT
Saved by @CodyyyGardner

THREAD
There’s much debate around the UK's recommended use of the AZ vaccine with a two-dose schedule and flexible timing of second dose. Some thoughts on the AZ recommendation (not Pfizer) based on available data with refs to some excellent threads.

 UK’s MHRA and JCVI are highly-experienced in vaccine assessments and recommendations, and they've surely weighed the benefits & risks of this recommendation carefully. That said, it would be good to see all the data underpinning their recommendation. 2/
https://t.co/NRcHbYxRIw
In general, vaccines should be taken on a schedule tested in an efficacy trial. But it wasn’t possible to conduct the typical dose and schedule optimization prior to these Ph3 trials, and those trials provided valuable data to inform these recommendations. 3/
The UK recommends a two-dose schedule, with the second dose between 4-12 weeks. This *is not* a single dose schedule. Given the data provided, and in the setting of limited supply, overstretched hospitals, and emergence of a more transmissible variant, this seems justifiable. 4/
The UK has important data on the AZ Vx that wasn’t available for Pfizer & Moderna at FDA's VRBPAC, including:
* single-dose efficacy through 4+ months; and
* single-dose immunogenicity (12+ weeks). 5/
https://t.co/vtbviE9VEx
The data shows the AZ vaccine maintains efficacy in the setting of a delayed second dose, although it’s not clear how fast this wanes over time. Delay of the second dose provides a better booster effect as measured by antibody levels, which is seen with other vaccines. 6/
The second dose is important because it can drive a more robust and higher quality antibody response through a process called affinity maturation. It's well-understood that longer intervals can provide a better boost. 7/ https://t.co/cqKIpomUHg
In my view, the immediate priority is prevention of severe disease that drives deaths and the strain on health systems. Efficacy against severe disease is likely better than overall vaccine efficacy. Data after the first dose is promising although the numbers are small. 8/
There’s nothing magic about the (short) 28d interval between doses, which was presumably chosen to ensure rapid onset of protection in Ph3. Vaccine efficacy won't disappear overnight with a delayed 2nd dose - it will wane over time, if at all. Ph3 data supports that concept. 9/
Yes there are risks of waning immunity, non-compliance with the second dose, confusion among the public, etc. Many are implementation considerations that can be addressed with planning and strong communication. 10/
It will be critically important to collect efficacy data around this “flexible second dose” schedule, esp in older adults & against severe disease, to inform licensure and recommendations in countries around the world that are counting on the introduction of this vaccine. 11/
Yes the AZ/Oxford studies had a number of issues, but we must remember that this highly-complex development program was executed in less than a year. And that Pfizer & Moderna's Ph3 execution & vaccine efficacy created very high expectations for all subsequent programs. 12/
The bottom line is that every country needs to make difficult policy decisions with the data they have, not what they'd like to have. There's no perfect answer here, but now that a decision has been taken, the UK can focus on maximizing the benefit and mitigating any risks. 13/

More from Government

@amuse
@amuse
@amuse
CAPITOL RIOT QUESTIONS FOR SPEAKER PELOSI: There is no group in America more interested in the safety and security of the Capitol than members of Congress. To that end, members have asked @SpeakerPelosi to answer these basic questions:

1/ What was your role in authorizing or denying National Guard support before and after Jan. 6?

2/ Reps. Rodney Davis, R-Ill., Jim Jordan, R-Ohio, and James Comer R-Ky., on Feb. 15 asked you five pointed questions about your role in Jan. 6 and your preservation and compliance with document requests. Will you answer them?

3/ After the 2011 shooting of now-former Rep. Gabby Giffords, D-Ariz., what changed with regard to security?

4/ After the shooting of Republican House Whip Steve Scalise, R-La., were any changes made to security?
GOVERNMENT
\U0001f1fa\U0001f1f8I Support Our Military & Law Enforcement\U0001f1fa\U0001f1f8
🇺🇸I Support Our Milita...
@TheWiseOwl_AZ
1. Sun. 24 Jan. Juan O Savin, Kat: "Juan O’Savin, Monkey Werx, and Ghost Ezra, You’re Watching a Movie!"

President Trump officially put us in NESARA with an EO on Nov. 2, 2020 & it will be NESARA elections that will be held on March 2, 120 days after NESARA was made official.
GOVERNMENT
Advertisement
\U0001f1fa\U0001f1f8I Support Our Military & Law Enforcement\U0001f1fa\U0001f1f8
🇺🇸I Support Our Milita...
@TheWiseOwl_AZ
1. Military Intelligence Contact: . He is confirming X’s sources, Bruce's sources, and other sources reporting that the bond redemption processing finished today Christmas Eve Thu 24 Dec and as of about 1 pm EST all banks in this country and globally started moving fully onto...

2. ... the QFS system in all their operations, as the St Germaine Trust and the Rodriguez Trust start on Christmas Day Fri 25 Dec to pay out very large tranches to the Global Collateral Accounts and UST and other central bank accounts that are free of Deep State control and...

3. ... interference in preparation to release the shotgun liquidity start when T4B is started, his current info matching Bruce's sources, T4B start currently set for approximately next Tue-Wed 29-30 Dec;
. He is confirming Mr. X’s sources saying that 2 separate groups in...

4. ... different geographic locations said that there is expected to be activity on the holiday as well as into the weekend and if so we in T4B will be in great shape soon thereafter next week.
. He is confirming that bond liquidity in bond holder accounts will begin to be...

5. ... released giving account holders 1% to 1.5% access to funds next Mon-Tue 28-29 Dec, & that the bond liquidity release will enable release of trillions in liquidity globally to paymasters to downstream payments to T1-4A as we in T4B get started by some time29-30 Dec;(edited)
GOVERNMENT
K\xe1y\xf2\u0323d\xe9 \xd2g\xfand\xe1mis\xed
Káyọ̀dé Ògúndámisí...
@ogundamisi
Interesting parapo meeting today, anger, lots of 'THEY' vs 'US'. The zoom meeting was well attended. People threatening fire, thunder, tagging those of us calling for calm "Traitors".

Then I asked, how many of your children were involved in the Ibadan killings today? SILENCE!

Then one of my "Comrade" himself and his wife are always jumping from @channelstv to @ARISEtv. I asked him, aside your television rounds, have you ever handled an AK47? Simple question, he called me a bastard.
I asked will your Ibadan radio station host 100 Eso's? SILENCE!

Then another one, he was Afenifere lackeys, during the Ajegunle crisis, the same one who chopped money meant for young Yoruba who were defending their streets, mane died needlessly. I asked when last he visited Eso zones across Yoruba land. SILENCE! He kept ranting Fulani bla bla

Then practical questions to another, do we have a list of our vulnerable settlements? Any attempt to activate our fighting organisations so that all manner of people don't go about attacking innocent non Yoruba. SILENCE!

That one pretended he had poor network. No answer!

Then another one, he said I had 'changed'. I told him, you cant have witnessed a wicked Yoruba ruling elite, hype up sons and daughters of the poor and personally attended the burial of many of those unsung heroes and not call for extreme caution and the need to truly be prepared
GOVERNMENT
NYC Angry Mom - #OpenSchools
NYC Angry Mom - #OpenS...
@angrybklynmom
Parents in cities, please pay attention to the reopening details from the Whitehouse.

Biden says "small classes". What we need to understand is how they plant to accomplish this.

Through "childcare programs in schools". We see this all over states w/ closed schools.


We need to grasp that the AFT, NEA, & local unions are systematically working to decouple education from childcare.

Their vision is your child sitting on a device all day, watched by a childcare worker, being "taught" from a Teacher working from

This isn't a paranoid conspiracy theory - it is already happening in the majority of districts across the US where schools are closed.

"Learning Hubs" open, supervised by childcare workers, sometimes in the same "unsafe" school

There is NO OTHER WAY to get "small classes" without Hybrid + wraparound childcare. Your child will spend 2-3 days per WEEK supervised by low wage workers and sitting on a laptop.

Here's

Fairfax,
GOVERNMENT

You May Also Like

JayneshKasliwal
JayneshKasliwal
@JayneshKasliwal
ULTIMATE GUIDE TO 21 and 200 Moving Average
SUNDAY THREAD 🔖
A trend Following System That will Help You Improve Trading immensely.

RETWEET AND SHARE 🔄
@kuttrapali26 @AmitabhJha3
#stocks #StockMarket
1/n

Moving averages
EMA and SMA
1. Exponential Moving Average (EMA) is similar to Simple Moving Average (SMA), measuring trend direction over a period of time.
2. However, whereas SMA simply calculates an average of price data, EMA applies more weight to data that is more current
2/


21 EMA : SHORT TERM TREND
1. Calculates the Average Price of past 21 days
2. A stock above 21 ema is in strong momentum , which will give pullbacks to 21 ema again and again.
3. Stock above 21 ema should never be shorted so as to stay with the trend
3/n

3. A stock which moves 10-15% above 21 ema will be too extended and hence will generally pullback
Stocks take dynamic support on 21 ema
4. You can Short only if its too extended like 15 to 20% from 21 ema ( Not advised )
#ADANIPOWER:
#pnbhousing
4/n


1. Whenever 21 ema is sloping upwards its called uptrend
2. Whenever 21 ema is sloping downwards its called dowtrend
3. Whenever 21 ema is sideways its called consolidation
⏫Buy in uptrend
⏬Sell in downtrend
Examples:
5/n
MOVINGAVERAGES , MOVING AVERAGE 20021 , ALL
Tej Dosa \U0001f602\U0001f9e0
Tej Dosa 😂🧠...
@ComedicBizman
(A THREAD)

18 Things I Would Do At 18:

I was a dumb 18-year-old. I thought I had the world figured out. I didn't.

I stayed up till the wee hours. Drank every liquor invented.

Partied non-stop. Woke up after noon.

Surfed the web aimlessly.

Read BS self-help.

Repeat.

If I could do it all over again, here's 18 things I would do...

PHASE ONE: GET MY MIND RIGHT

ACTION #1: Break the chains - I wish I made the decision earlier. I didn't. I was scared. Anxious. Nervous. I knew once I made the decision, there was no going back.

Don't be like me.

Make the decision at 18. The decision to pave your own path in life. To go against the herd. To choose your own adventure. To commit to whatever sets your heart on fire.

ACTION #2: Cut off every negative person in your life.

Scroll through the contacts in your phone...

Notice how the names make you feel.

Delete any and all names that fill you with doubt and negativity.

ACTION #3: Condition your mind to embrace the producer mindset instead of the consumer mindset.

Consume 20% of the time. Produce 80% of the time.

Case closed.

ACTION #4: Set an intention to make $10k a month and write it out every MORNING and NIGHT as if you already achieved it (in the past tense).

Visualize yourself already having the money as you write.

Cheesy?

Yes.

Does it work?

Yes.

PHASE TWO: EDUCATION
LIFE
Advertisement
Ranvijay Singh\U0001f1ee\U0001f1f3
Ranvijay Singh🇮🇳...
@ranvijayT90
#Thread The legend of Ekadash Mukhi Hanuman ji...


Mahadev himself narrated the story of Ekadash Mukhi Hanuman ji to Maa Parvati. Once a great monster named Kalkarmukh performed the severe penance of Brahma ji.


Pleased with the austerity of the demon, Brahma ji gave him a boon that the person who will have eleven Heads like you and who was born on the day of your birth, only he/she will be able to kill you. No one else will kill you.


After getting a boon from Brahma ji, Kalkarmukh created a ruckus in all three lok. He invaded Swarg and snatched all the rights of the Devtas and became himself the king of Swarg.


All Devtagan came to Shri Rama and asked him for help. Hearing the agony of the Devtagan, Shri Ram called his supreme devotee Hanuman ji and said, "Pawan Putra, Sankatmochan".
HANUMANBHAKTI
Zena Hitz
Zena Hitz
@zenahitz
I just finished Eric Adler's The Battle of the Classics, and wanted to say something about Joel Christiansen's review linked below. I am not sure what motivates the review (I speculate a bit below), but it gives a very misleading impression of the book. 1/x


The meat of the criticism is that the history Adler gives is insufficiently critical. Adler describes a few figures who had a great influence on how the modern US university was formed. It's certainly critical: it focuses on the social Darwinism of these figures. 2/x

Other insinuations and suggestions in the review seem wildly off the mark, distorted, or inappropriate-- for example, that the book is clickbaity (it is scholarly) or conservative (hardly) or connected to the events at the Capitol (give me a break). 3/x

The core question: in what sense is classics inherently racist? Classics is old. On Adler's account, it begins in ancient Rome and is revived in the Renaissance. Slavery (Christiansen's primary concern) is also very old. Let's say classics is an education for slaveowners. 4/x

It's worth remembering that literacy itself is elite throughout most of this history. Literacy is, then, also the education of slaveowners. We can honor oral and musical traditions without denying that literacy is, generally, good. 5/x
CULTURE
ArmaniTalks \U0001f399\U0001f525
ArmaniTalks 🎙🔥...
@ArmaniTalks
Shy people are either overthinking or highly observant of the social setting.

And in many cases it can be both.

'So what do I do?'

You learn the 75/25 law.

'What is that?'

The law of charisma...👇

Let's address the over thinkers first.

Do you have any idea why you overthink?

'Yea. Because others are judging how shy I am.'

Incorrect.

Others are thinking about themselves, not you.

But the fact that you think they are thinking about you, you fuck up the interaction.

Now you stay in your head too much & avoid the present moment.

A major no no in the social world.

Your tendency to think that others are judging you for being shy, coincidentally makes you more shy.

And that's when you start giving off a strange vibration to the social setting.

This is when you begin attracting comments like 'why are you so quiet?'
LIFE