If you're at all interested in justice, addiction and/or prisons in Singapore, this is happening now—must watch!
We\u2019ve just gone live on our Facebook page for today\u2019s dialogue on understanding drug use, addiction, and policy in #Singapore. Join us: https://t.co/neOQDJjZ3a pic.twitter.com/WPgzjZy6VI
— Transformative Justice Collective (@tjc_singapore) December 13, 2020
Ben: They tell us about prefront cortex & limbic systems but there's no one to guide me in real life when I come out & practice the skills.
Dr W: Training in Oz an eye-opener. Easier as a doctor or therapist treating someone there voluntarily rather than forced into system. There they had support services, make your own decision to get well.
[He's now trying to start slide sharing]
Dr Winslow going through American Society of Addiction Medicine definitions of "addiction" (not confined to substances). In SG predominant addictions used to be opoids, now stimulants/meth/novel substances (?)
Stats—both total & repeat users in SG slowly going up, but hugely better than 90s with per-year 10-15K people.
Difficulty with "drugs are bad & people who take them are bad": seen as "morally weak", "bad behaviour" must be "punished out of them". Caning, jail time, institutions
In SG, recidivism, 50% of total drug abusers made up of repeat offenders. Methamphetamine has taken lead as drug of choice. Treatment for this not as refined right now.
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs