1/ Recently, I learned about the concept of ‘struggle porn’. This refers to the fetish of sacrificing nearly everything (health, relationships, time) for your startup. I fear that this label is creating more harm than good.
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I shipped all these apps in 2020. Most of them generated $0.
🎬 https://t.co/JAhXqsuu6h $0
🌍 https://t.co/BrNUAhfiIT $0
💡 https://t.co/ZWcLfOH4aI $0
🐞 https://t.co/aghOxYEcPI $1.99
👍 https://t.co/2JhJLe27pW $3,025 in 10 days.
But that's ok, just keep shipping! My stories👇
🎬 https://t.co/wuiBp1XsYD is the first thing I created. It's a community for indie makers. The different thing is we post updates in videos. I created it for fun as I think the world doesn't need one more text-based forum, so I make a video one. No monetization plan so far.
🌍 https://t.co/fiwjgCWho5 is a social app. The idea is from Linktree, an app to share your social links. I thought it would be cool to add more visuals to it, and meanwhile we can explore others around. I also have no monetization plan for it. Make it for fun too.
💡 https://t.co/fZfL45uvVX is a platform to connect influencers with their fans. People says it's like @superpeer. But the only difference is it's all sync. Influencers don't need to commit their time to fixed slot. Fans pay to ask questions, influencers can answer at anytime.
Continuing Influenswer... I think the product has its potential. But for now maybe I didn't find the right niche to serve. Will re-evaluate it in future.
🎬 https://t.co/JAhXqsuu6h $0
🌍 https://t.co/BrNUAhfiIT $0
💡 https://t.co/ZWcLfOH4aI $0
🐞 https://t.co/aghOxYEcPI $1.99
👍 https://t.co/2JhJLe27pW $3,025 in 10 days.
But that's ok, just keep shipping! My stories👇
🎬 https://t.co/wuiBp1XsYD is the first thing I created. It's a community for indie makers. The different thing is we post updates in videos. I created it for fun as I think the world doesn't need one more text-based forum, so I make a video one. No monetization plan so far.
🌍 https://t.co/fiwjgCWho5 is a social app. The idea is from Linktree, an app to share your social links. I thought it would be cool to add more visuals to it, and meanwhile we can explore others around. I also have no monetization plan for it. Make it for fun too.
💡 https://t.co/fZfL45uvVX is a platform to connect influencers with their fans. People says it's like @superpeer. But the only difference is it's all sync. Influencers don't need to commit their time to fixed slot. Fans pay to ask questions, influencers can answer at anytime.
Continuing Influenswer... I think the product has its potential. But for now maybe I didn't find the right niche to serve. Will re-evaluate it in future.
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@EricTopol @NBA @StephenKissler @yhgrad B.1.1.7 reveals clearly that SARS-CoV-2 is reverting to its original pre-outbreak condition, i.e. adapted to transgenic hACE2 mice (either Baric's BALB/c ones or others used at WIV labs during chimeric bat coronavirus experiments aimed at developing a pan betacoronavirus vaccine)
@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2
@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj
@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 30, 2021
"we generated a mouse model expressing hACE2 by using CRISPR/Cas9 knockin technology. In comparison with wild-type C57BL/6 mice, both young & aged hACE2 mice sustained high viral loads... pic.twitter.com/j94XtSkscj
@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2
1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 2, 2021
2 papers:
Human\u2013viral molecular mimicryhttps://t.co/irfH0Zgrve
Molecular Mimicryhttps://t.co/yLQoUtfS6s https://t.co/lsCv2iMEQz
@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj

@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
