1/ As I prepare to launch the biggest thing of my career 👀 I've been reflecting on my journey to this point. And the simple truth is - design changed my life.
But not in the way you think as I did not become a designer.
At first, becoming part of the community was not easy.
1. I want to improve my writing this year.
2. I promised @EricFriedman I'd ship something by Monday.
3. This is a good reminder of how choosing an unclear path can sometimes work out.
4. I'm terrible at sharing personal things.
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I've been thinking about the "reframing of powerlessness as righteousness" with regards to design education, and I want to jot down some loose thoughts...
Around 2012, while on summer break from what I felt was a lackluster school year, I was kind of at a breaking point. A prominent designer was peddling this self-help program, a $6000 weeklong workshop that centered around dinner with him and his influential friends.
His response to a fan who was deeply inspired by him and wanted to be a better designer, who asked "what if I can't afford the $6000?" was "You simply don't *want* to afford it." It's not a priority for you. I remember seeing it on Facebook and getting up from my chair.
It was gross, and it felt like the latest incident in what seemed like a long generational road of manipulating impressionable young people into thinking that the only thing stopping them from having the lives of these visible figures was passion
It felt wrong. Absolutely wrong. I thought about my best friend from high school. Someone just as—if not more—talented than me in art. Both of us dreamed of going to the same art school. Only one of us did. His familial socioeconomics as his undocumented status made it impossible
A person who adamantly argues for why you are powerless and takes offense at your self-determination could not be more clear about what role they prefer you in.
— Salom\xe9 Sibonex (@SalomeSibonex) December 30, 2020
Around 2012, while on summer break from what I felt was a lackluster school year, I was kind of at a breaking point. A prominent designer was peddling this self-help program, a $6000 weeklong workshop that centered around dinner with him and his influential friends.
His response to a fan who was deeply inspired by him and wanted to be a better designer, who asked "what if I can't afford the $6000?" was "You simply don't *want* to afford it." It's not a priority for you. I remember seeing it on Facebook and getting up from my chair.
It was gross, and it felt like the latest incident in what seemed like a long generational road of manipulating impressionable young people into thinking that the only thing stopping them from having the lives of these visible figures was passion
It felt wrong. Absolutely wrong. I thought about my best friend from high school. Someone just as—if not more—talented than me in art. Both of us dreamed of going to the same art school. Only one of us did. His familial socioeconomics as his undocumented status made it impossible
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@EricTopol @NBA @StephenKissler @yhgrad B.1.1.7 reveals clearly that SARS-CoV-2 is reverting to its original pre-outbreak condition, i.e. adapted to transgenic hACE2 mice (either Baric's BALB/c ones or others used at WIV labs during chimeric bat coronavirus experiments aimed at developing a pan betacoronavirus vaccine)
@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2
@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj
@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 30, 2021
"we generated a mouse model expressing hACE2 by using CRISPR/Cas9 knockin technology. In comparison with wild-type C57BL/6 mice, both young & aged hACE2 mice sustained high viral loads... pic.twitter.com/j94XtSkscj
@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2
1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 2, 2021
2 papers:
Human\u2013viral molecular mimicryhttps://t.co/irfH0Zgrve
Molecular Mimicryhttps://t.co/yLQoUtfS6s https://t.co/lsCv2iMEQz
@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj

@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
