BC CATEGORY C19
Saved by @vliscony

BAYES' THEOREM: The basic reason we get so many false positives to COVID19. The disease is so rare that the number of false positives greatly outnumbers the people who truly have the disease: THE MATHS:
https://t.co/oLHyxYJW9H

 "Suppose that you are worried that you might have a rare disease. You decide to get tested, and suppose that the testing methods for this disease are correct 99 percent of the time"
"Suppose this disease is actually quite rare, occurring randomly in the general population in only one of every 10,000 people. If your test results come back POSITIVE, what are your chances that you actually have the disease? LESS THAN 1% chance that you have the disease!"
"The basic reason we get such a surprising result is because the disease is so rare that the number of false positives greatly outnumbers the people who truly have the disease"
Say mass testing of the contagious virus was done to 1 million people. In that million, 100 will really have the disease, 99 will be correctly diagnosed as having it. 999,900 of the million will not have the disease, but of those about 9,999 will be false positives! #BayesTheorem
1 in 2,000 INCLUDING FALSE POSITIVES classifies Covid19 as a rare disease in winter 20-21
https://t.co/29FNwq0Qw2
Stefano Scoglio, Nobel prize candidate 2018, has calculated a real false positive rate of 95% from official Italian Health Service numbers. This is in line with #BayersTheorem. Calculation in links in thread:
https://t.co/rthjPRJWeB
If we apply the 95% false positive (Scoglio) back to England positive test % incl. false positive: 0.05% (ONS), we get a real % of positives in England of 0.0025% of the population, or 1 in 40,000 people. This would confirm Covid19 as a rare disease as per #BayersTheorem.
Try this calculator for up to 100 tests. https://t.co/5TKEYpjd80
Severe Covid19 is a rare disease in England, if tests are 100% accurate, acc. to hospitalization numbers, it's 0.02% or 1 in 5,000 people.
https://t.co/kFnQVoCspb
#BayesTheorem applied to LF tests: https://t.co/3OrdS7ZFUJ
A simple example of #BayesTheorem with a prevalence of 0.1% (much higher than Covid19) an error range of 1% (RT-PCR Charité range est. 0.8-4%) and only 1,000 people tested: 91% false positives.
#BayesTheorem in simple terms: when medical mass testing includes asymptomatics & the disease affects a minority of the population, a very small margin of error in the testing process will mathematically result in the false positives being many times more than the real positives.
"Covid19"[😞] mass testing graph from The Economist. Y axis being % of test results either true or false. As share of population with active infection (X axis) is well under 1%, most positive tests are false, & most negative results are true. This is called #BAYESTHEOREM.
Latest England estimates:
https://t.co/8hsZ1hNjD7
How to increase the prevalence of a rare disease from 0.01% to 1%? Test the asymptomatics. What prevalence do we estimate Covid19 at including asymptomatic tested? Less than 1%. What could the true prevalence be if we exclude asymptomatic testing? 0.01%. It's called #BayesTheorem
Proof that Matt Hancock is aware of #BayesTheorem, he mentions Bayesian mathematics: https://t.co/hpZYDzD5Pe
As Matt Hancock is clearly aware of #BayesTheorem, if he wanted to avoid the false positives being many more than the true positives, he would not say ONS is applying rigorous Bayesian mathematics, he would instead not implement testing of any asymptomatics not linked to a case.
Matt Hancock is pre-empting the #BayesTheorem false positive trap by mentioning Bayesian mathematics himself in reply. A Freudian slip, a lapsus which reveals what he is really thinking: how do I increase false positives to make Covid19 prevalence appear worse than it really is?
So how does he do it? He implements mass testing of asymptomatics in Universities, then schools. He uses the hierarchical power structures in these institutions to convince healthy students they need to be tested. The schools get closed on false positives, false fear is created.
#BAYESTHEOREM @ Cambridge University. 0.4% of 262 students came back as positive after the first "test". All came back as negative after the second. Government only tests once. ONS would say there is 0.4% prevalence instead it's 0%.
#BAYESTHEOREM @ Cambridge University. 0.5% of 1,937 students came back as positive after the first "test". All came back as negative after the second. Government only tests once. ONS would say there is 0.5% prevalence instead it's 0%.
Sorry this should say 0.4% of 263 students https://t.co/eSNnhyOI4n
See what happens in #BayesTheorem? Number of asymptomatic testing increases & the estimated prevalence of the disease increases!! This can be addressed by requiring confirmatory tests of those who test positive when numbers are small, otherwise DON'T test asymptomatics.
Cambridge Pooled Testing Report #BayesTheorem
https://t.co/BYIzoTl64c
To have the same number of false negatives as false positives you need a disease that is present in 30% of the population. Covid19 affects less than 1%. This means the false positives VASTLY outnumber both the real positives & the false negatives. It's called #BayesTheorem.
Matt Hancock claim: "the ONS report..address directly the question how the ONS adjusts for potential false positives, due to the high but not perfect specificity of the PCR test. I am very happy for one of my academics to take him through the rigorous Bayesian mathematics"
"I am very happy for one of my academics to take him through the rigorous Bayesian mathematics, which I am sure will help to elucidate the debate on this matter still further." @MattHancock to @DesmondSwayne
https://t.co/pZcFlMBKEZ
I am waiting for one of @MattHancock's academics to take us through this as I have seen no evidence of @ONS adjusting for false positives according to #BayesTheorem https://t.co/ykB67TJORe
Professor Emeritus in Public Health, University of Arizona:
https://t.co/aidVGWOVqH
WHO wakes up to #BayesTheorem https://t.co/nDKklwMhQe

More from Robin Monotti FRSA MA BSc

Robin Monotti
Robin Monotti
@robinmonotti
Can any MP ask the government why early treatment kits to stop viral replication & infection are not made available cheaply & prescription free in pharmacies as they are in India? Is it lives we want to save or is it Big Pharma profits? Because the two are mutually exclusive.


There could even be competing kits, & the decision which to take could be left to doctors & patients, as happens with most medicines. The problem is that there is not one of these kits available cheaply & prescription free anywhere in the West.

Doxycycline, Ivermectin, Azithromycin, Hydroxychloroquine, Zinc, Vitamin D, Vitamin C, omega-3s, all approved as safe drugs decades ago. This is clearly not an issue of safety. It should be left to a doctor's experience & judgement whether they are effective or not, not academia.

A GP could simply state on his website: of all the kits I recommend Kit Z, then Kit Y etc. No need to wait hours for consultations, as soon as the symptoms are clear the self administered treatment begins, and thousands of lives are saved, as well as hospitals remain underwhelmed

There is no need to go to ER or ICU if people can buy early treatment kits from pharmacies. There is no need for any hospital to be overwhelmed. This problem could be resolved in days. There is simply no political will to save lives as it means to go against Big Pharma profits.
HEALTH
Robin Monotti
Robin Monotti
@robinmonotti
I have now re-examined this document:


It clearly does indicate both the risks of bacterial infection & to prescribe broad spectrum antibiotics as part of treatment:
"Collect blood cultures for bacteria that cause pneumonia and sepsis, ideally before antimicrobial therapy. DO NOT
delay antimicrobial therapy"

"6. Management of severe COVID-19: treatment of co-infections
Give empiric antimicrobials [broad spectrum antibiotics] to treat all likely pathogens causing SARI and sepsis as soon as possible, within 1 hour
of initial assessment for patients with sepsis."

"Empiric antibiotic treatment should be based on the clinical diagnosis (community-acquired
pneumonia, health care-associated pneumonia [if infection was acquired in health care setting] or sepsis), local epidemiology &
susceptibility data, and national treatment guidelines"

"When there is ongoing local circulation of seasonal influenza, empiric therapy with a neuraminidase inhibitor [anti-viral influenza drugs] should
be considered for the treatment for patients with influenza or at risk for severe disease."
HEALTH
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Robin Monotti MA FRSA\u2b50
Robin Monotti MA FRSA⭐...
@robinmonotti
"COVID-19 vaccines designed to elicit neutralising antibodies may sensitise vaccine recipients to more severe disease than if they were not vaccinated. Vaccines for SARS, MERS and RSV have never been

"data generated in the development & testing of these vaccines suggest a serious mechanistic concern: that vaccines designed empirically using the traditional approach (consisting of the unmodified or minimally modified coronavirus viral spike to elicit neutralising antibodies)"

"be they composed of protein, viral vector, DNA or RNA and irrespective of delivery method, may worsen COVID-19 disease via antibody-dependent enhancement (ADE)."

"This risk is sufficiently obscured in clinical trial protocols and consent forms for ongoing COVID-19 vaccine trials that adequate patient comprehension of this risk is unlikely to occur, obviating truly informed consent by subjects in these trials."

"Covid-19: vaccination roll-out correlates with worse mortality trends"
CATEGORY C19
Robin Monotti
Robin Monotti
@robinmonotti
The evidence based science shows that medical face masks for the healthy do not alter rates of community transmission of SARSCoV2 while they contribute to the plastic pollution of planet. Cloth & masks of other materials increase rates of infection through nebulization spread.

"Speaking through some masks dispersed largest droplets into a multitude of smaller droplets..smaller particles are airborne longer than large droplets (larger droplets sink faster), a mask might be counterproductive."
https://t.co/jBQlWRxcEL


Influenza like illness rates 3 times higher with cloth masks when compared to control group:
https://t.co/djT0mfutv9
Prof. Carl Heneghan, Oxford University: "The high quality trial evidence for cloth masks suggest they increase your rate of reinfection."


Please note, droplets smaller than 120 microns can't be measured. SARSCoV2 is 0.14 microns. This means that the nebulization effect of medical masks could not be measured, not that it does not happen. ⬇️


The really small aerosols <1 μm [the ones that pass through ALL surgical masks] can penetrate all the way to the alveoli - the basic units for gas exchange
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Robin Monotti
Robin Monotti
@robinmonotti
WHY MASKS DON'T WORK:
Coughing is NOT the issue.
Large droplets are NOT the issue. Breathing exhales MUCH MORE virus in fine aerosols than coughing. Finer aerosols bypass masks/nose & reach the lungs. Masks NEBULIZE. Solution is VENTILATION not face masks.
https://t.co/FMqYszHKVt


"Once direct measurement of particles containing viruses in exhaled breath was technically feasible, most particles (87%) with influenza viral RNA were found to be smaller than 1 μm."

"Influenza viral RNA was detected in the exhaled breath of 92% of adults. The fine particles contained 8·8-times more viral copies than did the coarse ones. Respiratory viruses have been found in both coughs (82% of participants) and exhaled breath (81% of participants)"

👉 "Human rhinovirus was collected more frequently in exhaled breath than in cough aerosols using a filter method." 👈

"The Middle East Respiratory Syndrome (MERS) coronavirus was isolated from seven room air samples from dedicated MERS units in two South Korean hospitals. All seven were positive by PCR and four of seven were positive on viral culture."
SOCIETY

More from Category c19

Alex Berenson
Alex Berenson
@AlexBerenson
1/ An excellent new paper from Denmark that tracks every vaccination given to nursing home residents there shows an 40% RISE in infections immediately after the first @pfizer dose and no efficacy at any point. Protection in this population after “full” vaccination is 64%...


2/ The researchers also tracked health-care workers, the other group in Denmark to receive the vaccine first. They actually had an even LARGER rise in infections immediately following dose 1, but overall higher protection at “full” vaccination (a week after dose 2) - 90%...

3/ This paper is the best yet (because it’s the least political). It is also in line with the Israeli and English data show once you wade through their spin. The takeaways are: The vaccine is much less effective in the people who need it most and DON’T DELAY THE SECOND SHOT...

4/ By the way, i#depending on how long the vaccine provides protection, its OVERALL effectiveness will be below whatever the peak figure is, maybe well below - you need a lot of good weeks to make up for that bolus at the beginning - but I don’t even want to go there.

5/ This paper also shows why the raw Israeli numbers are trash - if infections are declining overall (as they were in Israel and Denmark in February) looking at infections in the vaccinated population without adjusting for that trend markedly overestimates the vaccine effect.
CATEGORY C19
David Thunder
David Thunder
@davidjthunder
—TAKEAWAY LESSONS FROM PANDEMIC 2020-21: A THREAD—

Below, a few basic lessons I have drawn, as a political philosopher and informed citizen who has made it my business to closely follow political, social, economic, clinical, & epidemiological aspects of the pandemic:

1/ Most mainstream journalists cannot be relied upon to critically uncover, & impartially convey, the facts surrounding a complex & unfolding crisis. If you watch RTE, BBC, or CNN, you are fed naively one-sided stories laced with fear-mongering, misleading use of statistics, etc.

2/ If you wish to inform yourself about a public crisis like this pandemic, you must find commentators who have limited access to mainstream media, good credentials, & arguments that consider a wide range of available evidence. You need to be pro-active about diversifying sources

3/ Reliance by govts upon advisory committees with a clearly one-sided take on the pandemic (eg suppression at all cost) has led to catastrophic outcomes. Govts must diversify their scientific sources & encourage ROBUST scientific debate among their advisors.

4/ Hyper-centralised management of public health is ineffective. Decision-making power must be decentralised so that it can adapt quickly to local conditions. Care homes were badly hurt by top-down mandates that were sluggishly responsive to evolving conditions on the ground.
CATEGORY C19
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Abir Ballan \U0001f60a
Abir Ballan 😊
@abirballan
All you need to know about COVID19
FACTS NOT FEAR

Covid 19 is a disease caused by the SARS-CoV-2 virus. SARS-CoV-2 is one of 7 coronaviruses known to man. 1/n

The pandemic is real. Excess deaths were observed in many countries. Not all countries were affected in the same way due to pre-existing immunity, the health status of the population and demographics (the proportion of elderly in the population) 2/n
https://t.co/65elPq3gp5


COVID 19 presents a high risk for the very few and negligible risk for the many.

The infection fatality rate in different age groups:
<19 y, IFR= 0.003%
20-49 y: IFR= 0.02%
50-69 y: 0.5%
>70y, IFR=

Not everybody is susceptible to the virus. If reinfected, pre-existing immunity from related viruses gives protection from developing the disease or from developing serious symptoms.
4/n

“The evidence that a subset of people has a cross-reactive T cell repertoire through exposure to related coronaviruses is
COVID19 , CATEGORY C19
Bobby Rajesh Malhotra \u30c4
Bobby Rajesh Malhotra ...
@Bobby_Network
@welt published an article today on the “panic paper”-scandal in Germany.

Title is "Maximum collaboration”, showing @BMI_Bund / Horst Seehofer had a secret paper drafted in the 1st COVID-19 wave that dramatically depicted the threat.

A scandal of gigantic proportions. Thread⬇️


2/: @welt released 2 versions: long version as print, short-edit, online.

This thread focuses on the long version. It's of crucial importance-people around the globe understand this earthshaking scandal. Share.

English: https://t.co/qAbU6D8c0P

German: https://t.co/W2i1FtVrCg


3/: Mid-March 2020: Federal Minister of the Interior-Horst Seehofer (@BMI_Bund, @cducsubt) was on the edge: Christian Drosten (@c_drosten) & Lothar Wieler (@RKI) urgently warned: Germany was threatened w/ dramatic consequences if the country returned to everyday life too quickly.


4/: Horst Seehofer sent his Secretary of State Markus Kerber into the lane. The plan was to bring together leading scientists: they should produce a paper that would then serve as legitimation for further tough political measures, beyond Easter - now known as the “panic paper”.


5/: Markus Kerber launched a corresponding call to researchers via e-mail, 4 days later, the request was fulfilled: A classified paper, which presented the danger posed by the virus as dramatically as possible, and which quickly spread through the media.
CATEGORY C19
Dr Naomi Wolf
Dr Naomi Wolf
@naomirwolf
1/MUST-READ. THIS EXPLAINS EVERYTHING. 1995, "CDC Foundation" created. Allows Pharma to $$$ CDC. $28 million in ONE YEAR from Pharma, $13.5 million in ONE YEAR from @BillGates and Melinda Gates Foundation. CDC IS IN PART INVESTED IN PHARMA via

2/ Thus FUNDING what CDC says to US. I am furious:my state, synagogue "await CDC guidance". Also support vaccines. BUT CDC IS PROFITING AND FUNDED BY BILL GATES AND PHARMA. CDC inflates COVID data too, per peer reviewed study.COMPLETE CIRCLE OF CORRUPTION. Needs criminal charges.

3/ BINGO. TOTAL CORRUPTION. CDC Foundation "invested" ONE BILLION in "lifesaving programs" worldwide; millions of its funding from Pharma, Gates. "PARTNERS" WITH FOR PROFITS (as does NHS dashboard). SO CDC IS INVESTED/ALIGNED W FOR PROFIT COMPANIES and its guidance is corrupted.
CATEGORY C19

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Paul M Domenick\U0001f43a
Paul M Domenick🐺...
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10 Signs of Social Intelligence 🧠

1-Smile
2-Good posture
3-Strong eye contact
4-Fluid hand gestures
5-Let’s others talk more
6-Listens & relates
7-Comfortable Touching people
8-Walk with a swagger
9-Speaks at slower pace
10-Keeps calm under criticism

[ QUICK THREAD ]


1-Smile

How do you feel when you see someone that looks angry?

It’s a downer

No one will want to interact with you if you look pissed all of the time, it’s just negative energy

Plus, smiling is a sign of confidence and boosts others moods


2-Good posture

Don’t walk Into any social setting looking like the hunchback

It’s weak and makes you look low energy

Plus, you’re displaying low status with weak posture

Stand up straight with your chin up & chest out like a god

Walk like you’re proud of yourself


3- Strong eye contact

Ever shake someone’s hand & their eyes are either looking down or darting?

It’s weak & you probably won’t trust them

Or in conversation?

Eye contact while talking means you’re listening and paying *Attention*

Strong eye contact displays confidence


4-Fluid hand gestures

Use your hands to talk & express your points

Don’t stand there like a robot

Using the hands can make what you’re talking about exciting

It can also be used to emphasize

Exciting = positive emotion

Remember, making people FEEL is what’s important
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Noah Smith
Noah Smith
@Noahpinion
1/OK, I should really write another thread about university-centric regional development, because I think people often make some (very understandable) mistakes when thinking about this issue.

2/The biggest myth, I think, is that universities help regions by educating locals as undergraduates.

Skeptics of universities say: "But most of the people who graduate end up leaving."

3/In fact, most of what a university does for a regional economy is NOT about educating local kids.

Educating local kids is good for the nation, but doesn't help a region much.

The way a university helps a region is through

4/Undergraduates usually leave town after graduation.

But university RESEARCH pulls in OTHER smart people from other regions, and they stay there.

Here's a paper showing that this is the main way universities increase a region's human capital:

5/Research also pulls in business investment.

Companies want to partner with university labs, so they can commercialize the technologies the labs produce. So they invest in the labs, and sometimes they even put their offices in the town.
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Anu Satheesh \U0001f1ee\U0001f1f3
Anu Satheesh 🇮🇳...
@AnuSatheesh5
Agastya Muni & Kaveri River
#story
This is a story which describes how River Kaveri was brought on earth by Agastya muni. There was a king named Kavera lived in the Brahmagiri hills who prayed to Brahma for a child. He was blessed with a daughter whom he named Kaveri.


Agastya muni married her. A demon, named Shoorapadma, wanted to trouble people so he prevented rain from reaching South India. As a result famine occurred in South India.
Agastya Muni who came that way was very sad seeing this. He started to pray Mahadeva for a solution.


Shiva gave him small amount of Ganga water in his Kamandalu (small pot) and said wherever you spill this water the river will flow from there. Agastya Muni travelled lot of places to find a suitable place to pour water. Feeling tired he kept his Kamandalu and took rest.


At that time Ganesha took a form of crow and perched on the Kamadalu and made a hole that water began to flow as river Kaveri. This place is now called as Talakaveri (Karnataka), located in the Brahmagiri hill.


Tala Kaveri has temple for Agastheeswara, which denotes the story between Kaveri and Agasthya muni. Kaveri is a part of Ganga, thus, also called Dakshina Ganga.
🙏🕉🙏
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Vibhu Vashisth
Vibhu Vashisth
@VIBHU_Tweet
हिमालय पर्वत की एक बड़ी पवित्र गुफा थी।उस गुफा के निकट ही गंगा जी बहती थी।एक बार देवर्षि नारद विचरण करते हुए वहां आ पहुंचे।वह परम पवित्र गुफा नारद जी को अत्यंत सुहावनी लगी।वहां का मनोरम प्राकृतिक दृश्य,पर्वत,नदी और वन देख उनके हृदय में श्रीहरि विष्णु की भक्ति अत्यंत बलवती हो उठी।


और देवर्षि नारद वहीं बैठकर तपस्या में लीन हो गए।इन्द्र नारद की तपस्या से घबरा गए।उन्हें हमेशा की तरह अपना सिंहासन व स्वर्ग खोने का डर सताने लगा।इसलिए इन्द्र ने नारद की तपस्या भंग करने के लिए कामदेव को उनके पास भेज दिया।वहां पहुंच कामदेव ने अपनी माया से वसंतऋतु को उत्पन्न कर दिया।


पेड़ और पौधों पर रंग बिरंगे फूल खिल गए और कोयलें कूकने लगी,पक्षी चहकने लगे।शीतल,मंद,सुगंधित और सुहावनी हवा चलने लगी।रंभा आदि अप्सराएं नाचने लगीं ।किन्तु कामदेव की किसी भी माया का नारद पे कोई प्रभाव नहीं पड़ा।तब कामदेव को डर सताने लगा कि कहीं नारद क्रोध में आकर मुझे श्राप न देदें।

जैसे ही नारद ने अपनी आंखें खोली, उसी क्षण कामदेव ने उनसे क्षमा मांगी।नारद मुनि को तनिक भी क्रोध नहीं आया और उन्होने शीघ्र ही कामदेव को क्षमा कर दिया।कामदेव प्रसन्न होकर वहां से चले गए।कामदेव के चले जाने पर देवर्षि के मन में अहंकार आ गया कि मैने कामदेव को हरा दिया।

नारद फिर कैलाश जा पहुंचे और शिवजी को अपनी विजयगाथा सुनाई।शिव समझ गए कि नारद अहंकारी हो गए हैं और अगर ये बात विष्णु जी जान गए तो नारद के लिए अच्छा नहीं होगा।ये सोचकर शिवजी ने नारद को भगवन विष्णु को ये बात बताने के लीए मना किया। परंतु नारद जी को ये बात उचित नहीं लगी।
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Michael Dearing
Michael Dearing
@mcgd
An irony of facebook's situation.

Sheryl got her MBA at Harvard. One of the most famous cases (Extra Strength Tylenol) in one of the most famous classes (Business History) she took: in 1982, someone put cyanide in Extra Strength Tylenol capsules and killed 7 people in Chicago.

What do you do when someone turns your product into a weapon? When they use the system you built to harm? James Burke, CEO of J&J, was shockingly open with the public, he pulled the product and made significant packaging changes to make product safer (but not tamper-proof).

He over-shared every step along the way re investigation, redesign, stood up as both CEO and human. The reintroduction of new Extra Strength Tylenol succeeded. Burke saved the brand.

But four years later it happened again. A killer put cyanide in the capsules, this time a woman in Yonkers died. Same CEO, Burke, pulled the product again, completely changed the form factor from capsule to caplet and relaunched *again*. It worked *again*. How'd they do that?

Burke (CEO) tapped J&Js goodwill bank account w/ the public. Two big withdrawals from that bank account in four years + 8 dead bodies! But his honesty, openness, humanity (choked up about the deaths more than once), humility kept the goodwill bank balance positive the whole time.
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