https://t.co/LjpdlHa0C7 is getting a good face-lift.
Samples now have variant tables with annotation on their impact to the gene.
There is also an IGV integration. You need IGV installed locally but the Start|Jump links will open up you BAM file in IGV.

Just published 15,000+ words on security keys. 🔐📱💻

With SIM attacks at their highest, now is a great time to take a closer look at your online security.

Removing SMS from your two-factor auth is a start, but authenticator apps have downsides too...

https://t.co/Dk0MPJHL2V

Just look at these headlines from recent SIM swap and port attacks.

It's all too established for attackers to find ways to socially engineer control of your phone number and start gaining control of your accounts.

I first talk about some general security tips.

Unfortunately not all websites let you remove your phone number from accounts.

You may consider migrating your phone carrier to @googlefi , which requires email account access to do anything (and can be locked down with security keys and even Advanced Protection)

Beyond SMS, I talk about issues that TOTP authenticator apps (the code generators) have as a form of two-factor auth. They're so, so much better than relying on SMS for your second factor but they still have issues like utilizing shared secrets and lacking phishing prevention.

Enter security keys!

Utilizing public key cryptography they don't have any shared secret between the client and the server. They prevent phishing by taking the website domain into account.

Even if you get tricked by a clone phishing website, your key won't.

The 2018 State of JavaScript survey is out. They got 20,000 responses and have some delicious, delicious data. I'mma thread in some highlights:

First up: JavaScript flavors. There's TypeScript at 47% adoption, a tad higher than npm's own survey results (which said 46%). npm's survey is coming up again soon and will ask about TypeScript in a lot more detail.

I really, *really* like SoJ's "would not use again" question, which lets people who've abandoned a tech self-identify. This is noticeable in the graph above with Flow users -- 41% of people who've used Flow say they wouldn't use it again.

Now JavaScript frameworks. It's been a full year since npm's survey, so these numbers differ from ours in the directions I expected:
React 65% (vs. 60%)
Vue 29% (vs. 24%)
Ember 5% (vs 4%, I was expecting a bigger rise)

But there's a shocker in here: Angular.

npm's survey had Angular at 40% last year and SoJ has it at either:
- 58% (if you include those who don't want to use it again)
- 24% (if you count only those who like it)
Since npm's question didn't ask if they intend to *continue* using it I think that might explain this.

Java was first released in mid-1995, just 6 months before JS.

By 98, when I went to college, Java was already used for all the first level courses in the CS program.

How did it catch on so quickly (just 3 years) to shift university curriculum, which is usually so slow/behind?

I wonder why Java was so respected and JS was not? Why/how was Java already seen as such a stable and mature language?

Not just Java, other languages (like python) were also released around/near 95, and also seemed to get to "mature" respect status. much quicker.

I bring all this up because my impression of Java in 98 was that it had been around "forever" (as had C++ first developed in 79, but not standardized until 98!), but that's not. true at all. These were all new languages around the same time.

I'm sure the language designs had different merits, and the target applications meant a different perception and reception, but...

it sure seems like the industry (and academics) just decided Java and C++ were the stable mature ones and langs like JS were toys.

BTW, before you assume JS was nascent/immature b/c the web wasn't much of a thing yet, remember that JS was actually released as LiveScript on the server before it was released in a browser. So "server-side JS" was always part of the story, not just Node 15 years later in 2009.

A long time ago I coded up a feature for SocialCoder which converts a link - any link - to a short URL. I use it all the time for sharing links to volunteer profiles and to volunteer opportunity listings.

The feature doesn't care what the link contains, it just hashes the URL, including any query params, and returns a shortened code.

More recently, around Christmas time, I added another feature where I can click a button to send a template notification to a charity that their new listing has been reviewed and published. I call it a next-steps email.

For the past few weeks, its all been working well. Its nice to keep automating things that previously were done by hand.

Fast forward to today.

A new opportunity listing is posted by a charity.

I review and publish it, tweet about it, then click a button to send the charity an emailed notification of next steps.