@Iplaywithgerms This paper gives documentation on software (with causal reasoning, assumptions reviewed in appendix) for a parametric approach to estimating either "total effects" or "controlled direct effects" with competing events and time-varying

@JuliaLMarcus @Iplaywithgerms Total effects capture paths by which treatment affects competing event (e.g. protective total effect of lifesaving treatment on dementia may be wholly/partially due to effect on survival). Controlled direct effects do not capture these paths
@JuliaLMarcus @Iplaywithgerms More detailed reasoning on the difference and tradeoffs between total and controlled direct effects and causal reasoning in the point treatment context provided here along with description of some estimators and code.
https://t.co/uRQcU1NqJd
@JuliaLMarcus @Iplaywithgerms If you are familiar with more robust approaches like IPW or even better TMLE for time-varying treatment, these are trivially adapted to go after the controlled direct effect by simply treating competing events like loss to follow-up (censoring). e.g. see
https://t.co/kew3HltAev
@JuliaLMarcus @Iplaywithgerms Examples of IPW estimation of the total effect of a time-varying treatment described in Appendix D of this paper:
https://t.co/RNhcgTBMkb
And here
https://t.co/rMWmwFBWwV
Others in reference lists of above papers.
@JuliaLMarcus @Iplaywithgerms As discussed here
https://t.co/uRQcU1NqJd
even when treatment is time-fixed, hazard ratios (whether cause-specific or subdistribution) do not quantify causal effects (even when counterfactual contrasts) except in special circumstances that will not hold in most studies
@JuliaLMarcus @Iplaywithgerms These circumstances can fail even when the study is a perfectly executed trial (no loss to follow-up, perfect adherence to the treatment assignment) and even when the treatment does not affect the competing event.
@JuliaLMarcus @Iplaywithgerms More recent work on the separable effects provides notions of mechanism in this setting that, unlike controlled direct effects (effects under eliminating competing events), have real-world, clinical relevance. This does not accommodate t-v treatments (yet, in the works).
@JuliaLMarcus @Iplaywithgerms Here are some papers on the separable effects for point treatments (Epidemiology commentary forthcoming focused on fertility trials that is less technical):
https://t.co/35OJDe8dD6
https://t.co/O08FNqPWWb
https://t.co/wKCrItvNhT

More from Software

forgive my indulgence but 2020's been a big year for @shmuplations, so here's a look back at everything that went up over the last twelve months—there's a lot of stuff I'm sure you all read & other things you'd be forgiven for missing, so let's recap (thread)

the year kicked off with shmuplations' first big video project: a subtitled translation of a 2016 NHK documentary on the 30th anniversary of Dragon Quest which features interviews with Yuji Horii, Koichi Nakamura, Akira Toriyama, and Koichi Sugiyama
https://t.co/JCWA15RTlx


following DQ30 was one of the most popular articles of the year: an assortment of interviews with composers Yuzo Koshiro and Motohiro Kawashima concerning the music of Streets of Rage 1, 2 & 3 https://t.co/QUtyC9W12Z their comments on SoR3 in particular were full of gems


Game Designers: The Next Generation profiled six potential successors to the likes of Shigeru Miyamoto & Hironobu Sakaguchi, some of who you may recognise: Kazuma Kaneko, Takeshi Miyaji (1966-2011), Noboru Harada, Kan Naitou, Takashi Tokita & Ryoji Amano https://t.co/lWZU3PLvwX


from the 2010 Akumajou Dracula Best Music Collections Box, a subbed video feature on long-time Castlevania composer Michiru Yamane https://t.co/NMJe4ROozR sadly, Chiruru has since passed; Yamane wrote these albums in his honor

https://t.co/orlgPTDsKK

https://t.co/QnQl8KI9IX

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