BC SOFTWARE
Saved by @CodyyyGardner

@Iplaywithgerms This paper gives documentation on software (with causal reasoning, assumptions reviewed in appendix) for a parametric approach to estimating either "total effects" or "controlled direct effects" with competing events and time-varying

 @JuliaLMarcus @Iplaywithgerms Total effects capture paths by which treatment affects competing event (e.g. protective total effect of lifesaving treatment on dementia may be wholly/partially due to effect on survival). Controlled direct effects do not capture these paths
@JuliaLMarcus @Iplaywithgerms More detailed reasoning on the difference and tradeoffs between total and controlled direct effects and causal reasoning in the point treatment context provided here along with description of some estimators and code.
https://t.co/uRQcU1NqJd
@JuliaLMarcus @Iplaywithgerms If you are familiar with more robust approaches like IPW or even better TMLE for time-varying treatment, these are trivially adapted to go after the controlled direct effect by simply treating competing events like loss to follow-up (censoring). e.g. see
https://t.co/kew3HltAev
@JuliaLMarcus @Iplaywithgerms Examples of IPW estimation of the total effect of a time-varying treatment described in Appendix D of this paper:
https://t.co/RNhcgTBMkb
And here
https://t.co/rMWmwFBWwV
Others in reference lists of above papers.
@JuliaLMarcus @Iplaywithgerms As discussed here
https://t.co/uRQcU1NqJd
even when treatment is time-fixed, hazard ratios (whether cause-specific or subdistribution) do not quantify causal effects (even when counterfactual contrasts) except in special circumstances that will not hold in most studies
@JuliaLMarcus @Iplaywithgerms These circumstances can fail even when the study is a perfectly executed trial (no loss to follow-up, perfect adherence to the treatment assignment) and even when the treatment does not affect the competing event.
@JuliaLMarcus @Iplaywithgerms More recent work on the separable effects provides notions of mechanism in this setting that, unlike controlled direct effects (effects under eliminating competing events), have real-world, clinical relevance. This does not accommodate t-v treatments (yet, in the works).
@JuliaLMarcus @Iplaywithgerms Here are some papers on the separable effects for point treatments (Epidemiology commentary forthcoming focused on fertility trials that is less technical):
https://t.co/35OJDe8dD6
https://t.co/O08FNqPWWb
https://t.co/wKCrItvNhT

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Abhiram Reddy
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@nrabhiram
It’s been a minute since I’ve written code. So, I figured that now might be a good time to start learning how to use the Blueprint system in #UnrealEngine. I felt that it’d be interesting to share my progress and mistakes. So here goes!
🧵

1.
Firstly, I made use of the auto-rigging feature in Mixamo to give my character a skeleton. This allows you to use the Mixamo animations for the character in Unreal Engine.


2.
In the Animation Blueprint, I tried to add a punching state to the character. The problem I faced initially was that the character glides while punching. This occurs because multiple states of the animation are active (as their transition conditions are satisfied).


3.
There are a couple of solutions for this:

👉Blending the punch and idle states (character can punch while running) by using the Layered Blend Per Bone node.

👉Disabling input while the punch occurs.


4.
I didn’t like the outcome when I blended the animations. as the hip rotates more than we’d like it to. This leads to the character punching upwards and to the left. This isn’t favorable as the enemy is usually straight ahead. Disabling the input worked way better!
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Eric Seufert
Eric Seufert
@eric_seufert
Facebook -- having taken out full-page ads in the NYT, Washington Post, and WSJ -- is generally seen as the primary victim of the new app privacy controls coming in iOS14. But Google is perhaps even more vulnerable to ATT. Why has Google remained silent? (1/X)

2/ First, background: here's a high-level overview of how ATT / IDFA deprecation impacts advertisers and ad networks, and why this whole ordeal has put advertisers and ad networks into a state of panic:

3/ Google is equally as susceptible to harm from ATT as Facebook. Google's UAC product -- esp its tROAS and tCPA campaign objectives -- relies as much on IDFA-indexed monetization and engagement data as FB's mobile product does. But Google has one big weakness wrt ATT: YouTube

4/ Broadly, view-through attribution accounts for a disproportionate % of conversions from YouTube app install impressions. This means: user sees the YT ad, doesnt click, downloads app later, & Google is able to claim it by reconciling IDFA seen at impression to IDFA seen in app

5/ View-through attribution is nonexistent in the ATT paradigm as it relies on the IDFA; some significant portion of YT's attributed conversions will evaporate. So why isnt Google vocally opposing ATT? Two reasons: consumer optics and its duality as ad network / mobile platform
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John Fetterman
John Fetterman
@JohnFetterman
buffalo uses dominion scoreboard software so not really


DEAD PEOPLE SCORED FOR BUFFALO!

A truck delivered off a suitcase full of points at halftime from Canada for Buffalo.

#StopTheSteel !!!!

I’ll be submitting sworn affidavits from Steelers fans than they saw the Buffalo rigging the game but I want to emphasize that I’m not under oath.
SOFTWARE
Yan Cui is making the AppSync Masterclass
Yan Cui is making the ...
@theburningmonk
I've gotten a few questions about Aurora Serverless v2 preview, so here's what I've learnt so far. Please feel free to chime in if I've missed anything important or got any of the facts wrong.

Alright, here goes the 🧵...

Q: does it replace the existing Aurora Serverless offering?
A: no, it lives side-by-side with the existing Aurora Serverless, which will still be available to you as "v1".

Q: Aurora Serverless v1 takes a few seconds to scale up, that's too much for our use case where we get a lot of spikes. Is that the same with v2?
A: no, v2 scales up in milliseconds, during preview the max ACU is only 32 though

Q: is the cold start for Aurora Serverless v2 still a few seconds?
A: yes, unfortunately...
Q: so if you want to avoid cold starts, what's the minimum ACU you have to run?
A: minimum ACU with v2 is 0.5

Q: does v2 still scale up in double increments, e.g. 4 ACU -> 8 ACU?
A: no, it scales up in increments of 0.5 ACUs, so it's a much tighter fit for your workload, so you'll waste less money on over-provisioned ACUs
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C\U000100cfrtex Futura
C𐃏rtex Futura
@cortexfutura
[[Knowledge Management]], [[Reproducible [[Social [[Science]]]]]], and [[Academic Workflow]]s – 100 Tweets for @threadapalooza 2020, let's go
#roamcult #𐃏
1/100

Pandoc is a magical piece of software, and if you're not using it for your academic writing you're missing out. Compile (basically) any document format to (basically) any other document format.
2/100

While Pandoc is fantastic, it's a bit like ffmpeg: extremely powerful, but without GUI apps too few people will use it. ffmpeg has a ton of GUI apps that basically just wrap the CLI, Pandoc doesn't have enough of them.
3/100

Citekeys + CSL files + Pandoc can easily cut ~10+ hours from your writing workflow. Citekeys come from LaTeX-Land, you can use them through Pandoc with anything. And CSL files make it super easy to switch citation styles.
4/100

Since many journals have their own version of popular formats, every journal should be required to publish a CSL file, LaTeX and Word Pandoc template ready for submission. I don't want to think about the collective hours wasted formatting stuff for submission.
5/100
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.

The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains

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https://t.co/EwwJOSa8RK


In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa


Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
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1/x Fort Detrick History
Mr. Patrick, one of the chief scientists at the Army Biological Warfare Laboratories at Fort Detrick in Frederick, Md., held five classified US patents for the process of weaponizing anthrax.

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Under Mr. Patrick’s direction, scientists at Fort Detrick developed a tularemia agent that, if disseminated by airplane, could cause casualties & sickness over 1000s mi². In a 10,000 mi² range, it had 90% casualty rate & 50% fatality rate


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https://t.co/sHqSaTSqtB


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Sri Sanjeevi Rayar Temple located in Ayyangar Kulam,near Kanchipuram,TN

#Thread

Ancient but beautiful temple dedicated to Hanuman. This temple is a legendary one. According to the Sthala Puranam of Sanjeevi Rayar temple,it is associated with an episode from Ramayana.


Legend story -Hanuman was flying from Himalayas to Lanka bearing Sanjeevi hill to revive Lakshmana during battle between Rama& Ravana, a piece of the Sanjeevi Parvat fell at this place.Many believe this legendary story & even today that no one here dies of any kind of poisoning.

From historical background of the temple it is known that temple was originally built by a great scholar &administrator Kotikanyadanam Lakshmikumara Tatacharya. Temple itself&village were named following name of great scholar Tatacharya, who was then popularly known as Ayyangar.

He was the royal preceptor of Vijayanagara emperor Venkata Raya who had his capital at Chandragiri in AP.Upon returning from a pilgrimage,robbers tried to attack Tatacharya at this place. Being a great devotee of Hanuman,he instantly composed a poem in Sanskrit praising Hanuman.


The bandits immediately ran away &Tatacharya decided to build a temple dedicated to Anjaneya at that very place.This Sanskrit poem is called Hanumad Vimshati, has been inscribed in Grantha script inside this temple.The huge temple tank called Tatasamudram, in honor of Tatacharya.
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We're basically fucked.

The tech world has gotten so huge, self-reinforcing, and insulated from reality they can no longer even vaguely look at themselves (and their actions) as others do. They just live on a different planet than most people.

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Techies take weird, improbable visions, and make them realities: some BS pitch deck to a VC, mixed with money and people, really does turn into some novel thing.

Most people work inside a legacy industry that's evolved that way over time (usually for good reasons), and they think about the future via some analogy with their present (which is a function of a long-ago past). The interruption that tech will introduce is often hard to grasp.
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