Finally watched The Bee Gees doc. I’ve always been a fan but I have new respect for their artistry.

I am *especially* glad that the doc explicitly called out the fact that the “death of disco” was pointedly homophobic and racist.

1/People I know on the Right tend to be obsessed with the idea of "crimethink", taboos, and the (supposedly) oppressive, omnipresent enforcement of liberal cultural norms.

Why?

My new theory: A lot of it is guilt.

2/It's true that in some circles - the media, universities, many big corporations - liberal norms *are* enforced to some degree, and the enforcement has probably gotten stronger in recent years.

But I don't think this explains all of the Right's obsession.

3/The stereotype is that people on the Right tend to be more threat-sensitive. That would help explain the perception that liberal norm-enforcers are lurking everywhere, ready to pounce and anathematize anyone who makes a misstep.

But I don't think that's all of it either.

4/And of course, it's always fun - whether you're on the Right or the Left, or playing a video game, or whatever - to style yourself as the brave iconoclastic rebel fighting against the oppressive forces of blah blah blah.

But I don't think this is all of it, either.

5/The reason I think it's more than these things is that even *in private*, people on the Right express their "crimethink" ideas very gingerly and hesitantly.

I get the sense that they're not just afraid of external censure, but have also internalized liberal norms.

For those traveling to DC on Jan. 6th, I'm a native to the area and I would like to share with you what I will be doing this time and what I have done for the last two rallies...1/

#2020yearinreview
My coverage and commentary of San Francisco homelessness in the past year.

To make it more interesting, I'm interspersing quotes throughout this thread ⬇️

‘The letters or cards that I had… they could never be replaced. It just meant more to me than a zillion dollars.’ -- Derrick, who lost his tent, ID and letters from his mother to sweeps by

'We’re essentially under arrest. On an equally interesting note, I haven’t had any medical examination since my arrival — a bit strange considering what I’m here for.' -- Ken, shelter client who was tested positive for

'The shelter in place has given us permission to be out here, otherwise it was just cat and mouse' -- Toro, whose tent camp in Castro District was temporarily reprieved from police

'It’s scary coming here, especially for people using on the street and with mental health issues, there’s a lot of paranoia. I didn’t know if I was being taken to a black site.' -- Joshua Owens, on his initial trepidation about entering a SIP hotel

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10