THREAD

1. Dear Primary, Secondary, Further ed and Higher ed colleagues,

Many of you may have experienced working with our youngest children- but as the "foundation stage" the work that happens in these early years will be of great importance to you....

My dad’s first memory is hiding under a table 80 years ago tonight, when Nazis took his dad to Dachau on #Kristallnacht.

His parents, my Omi and Opi, always considered themselves more German than Jewish, so they didn’t think they’d get swept up in the madness.

Opi was taken to city hall with other Jews and lined up against a wall. He thought he was going to be shot.

He always remembered when they got to Dachau there were pajamas with Jewish stars waiting on their cots. Obviously not a spontaneous thing.

He was very lucky. His family got him a fake Uruguayan visa and he was out of Dachau six weeks later. “Before Christmas,” my dad recalls.

r u abbreving less rn?

Since the switch to 280 characters a year ago, we've seen an increase in people writing out full words and phrases.

All about the please and thank you.

With 280 characters, people are saying 'please' (+54%) and ‘thank you’ (+22%) more.

THANKS!!!!

💬💬💬

280 characters later, there are more ? and replies to Tweets. More room, more conversations!

As a mom of 4 I have spent a significant amount of my time discussing the virtues of truth telling and the consequences of telling a lie, at this moment one of the kids is writing me an essay on using self-control to ensure her words are true.

On Monday @TuckerCarlson said, “The Green New Deal has come, believe it or not, to the state of Texas. How’s it working out so far?”

First GND is a resolution, second it hasn’t even been past, 3rd, we’re talking about TX. This is objectively false.

He went on to say, “Not a single major American city is prettier or more functional than it was in 1950. The parks that previous generations so lovingly built are filled with vagrants and junkies."

"The monuments they constructed are covered with spray paint. Public transportation is a disgrace. It’s filthy, the streets are dangerous. Are you really surprised that Cory Booker was once the mayor of Newark, New Jersey? You shouldn’t be.”

Wow, that’s a lot to unpack and has little to do with the lack of power in TX. For myself I believe the best is yet to come. I see the dog whistles there, and it’s an excellent example of racist demagoguery and a sure path towards the destruction of our democracy.

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10