Time to act: thread on why we need to close schools, borders, and ban all household mixing RIGHT AWAY.

To those arguing winter is always like this in the NHS: you are wrong. I faced four serious winter crises as Health Sec and the situation now is off-the-scale worse than any of those.
It’s true that we often had to cancel elective care in Jan to protect emergency care but that too is under severe pressure with record trolley waits for the very sickest patients https://t.co/phEd47ztne
Even more worryingly fewer heart attack patients appear to be presenting in ICUs, perhaps because they are not dialling 999 when they need to
https://t.co/CM1548589N
Full credit to NHS for keeping cancer services open but in Wave 1 there was still a 2/3 drop in cancer appts: people didn’t come forward to GPs or want to go to hospitals, with many potentially avoidable cancer deaths. We hoped to avoid that this time but now looking unlikely.
Excellent analysis by @NeilDotObrien shows the reason for all this pressure: 1/3 more hospital beds now taken up nationally by covid patients than in Wave 1 (50% in SE). Having a new strain in the middle of winter is clearly having a massive impact https://t.co/d3L3suUlxh
No 1 lesson is countries that act early & decisively save lives & get their economies back to normal faster. Wuhan is now free of any restrictions - but Uni of Southampton show if they’d locked down 1 week earlier they would’ve reduced infections by 2/3. https://t.co/1uWplUpIJA.
We therefore cannot afford to wait: all schools should be closed, international travel stopped, household mixing limited and the tier system reviewed so that the highest tier really does bring down infection levels (as with the first lockdown).
Also with vacancy levels at 2-3 times normal because of self-isolation & covid, NHS staff who are risking their lives for us MUST be put at the front of the queue for vaccines. This will stop our hospitals falling over and help keep their patients safe. It is also our moral duty.
The good news is that unlike before these restrictions will be time limited to the 12 weeks or so it will take to get the vaccine out to those most vulnerable to covid - so there is light at the end of the tunnel.
I know all these things will be under consideration with decisions potentially imminent. My point is in the face of exponential growth even waiting an extra day causes many avoidable deaths so these plans must now be urgently accelerated.

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@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice


@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2


@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj


@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o
The chorus of this song uses the shlokas taken from Sundarkand of Ramayana.

It is a series of Sanskrit shlokas recited by Jambavant to Hanuman to remind Him of his true potential.

1. धीवर प्रसार शौर्य भरा: The brave persevering one, your bravery is taking you forward.


2. उतसारा स्थिरा घम्भीरा: The one who is leaping higher and higher, who is firm and stable and seriously determined.

3. ुग्रामा असामा शौर्या भावा: He is strong, and without an equal in the ability/mentality to fight

4. रौद्रमा नवा भीतिर्मा: His anger will cause new fears in his foes.

5.विजिटरीपुरु धीरधारा, कलोथरा शिखरा कठोरा: This is a complex expression seen only in Indic language poetry. The poet is stating that Shivudu is experiencing the intensity of climbing a tough peak, and likening

it to the feeling in a hard battle, when you see your enemy defeated, and blood flowing like a rivulet. This is classical Veera rasa.

6.कुलकु थारथिलीथा गम्भीरा, जाया विराट वीरा: His rough body itself is like a sharp weapon (because he is determined to win). Hail this complete

hero of the world.

7.विलयगागनथाला भिकारा, गरज्जद्धरा गारा: The hero is destructive in the air/sky as well (because he can leap at an enemy from a great height). He can defeat the enemy (simply) with his fearsome roar of war.