A thread about panic buying and stockpiling outrage. Availability (or lack thereof) of products in supermarkets is a complex and multi-layered issue.

Basically, it's not just people being cunts. 1/

Count Giancarlo Cicogna was a member of the Ciga hotels clan. He was with Ghislaine Maxwell for 4 years. He was 'the man who moulded the Ghislaine we now see. He told her where to get her hair cut, and what to wear.'
https://t.co/XorCl9VKW6

There is a very Ghislaine like character named Madam Anais in the movie La Belle De Jour who runs a Brothel. The film was produced by Marina Cicogna.

Private View of 'Once Upon Time' an Exhibition of Photographs by Marina Cicogna Sponsored by Fiat at the Little Black Gallery,

My view Marina Cicogna looks like Dottie in the Disney Channel series WandaVision.

NY Times covered a story of Countess Marina Cicogna, a woman with a very intetesting life. I am sure she knows many secrets and that gives her power over people of influence.

1/OK, I should really write another thread about university-centric regional development, because I think people often make some (very understandable) mistakes when thinking about this issue.

2/The biggest myth, I think, is that universities help regions by educating locals as undergraduates.

Skeptics of universities say: "But most of the people who graduate end up leaving."

3/In fact, most of what a university does for a regional economy is NOT about educating local kids.

Educating local kids is good for the nation, but doesn't help a region much.

The way a university helps a region is through

4/Undergraduates usually leave town after graduation.

But university RESEARCH pulls in OTHER smart people from other regions, and they stay there.

Here's a paper showing that this is the main way universities increase a region's human capital:

5/Research also pulls in business investment.

Companies want to partner with university labs, so they can commercialize the technologies the labs produce. So they invest in the labs, and sometimes they even put their offices in the town.

If you know me, you know I don't like broadcasting details about my personal life on this website, but I have been getting asked why I'm not doing Christmas this year so I just wanna put this whole mess to bed. First of all, I don't agree with gay marriage... (1 of 4,625)

... full of dog food and she said, "I'm pretending this is ice cream! Treat me like a baby!" and proceeded to hump her own arm and I thought, "something tells me this isn't the real Norah Jones"... (117 of 4,625)

...cost me $7,000. I had to put it on two separate credit cards! It wasn't 'til I got to my car that I realized "that's way too expensive for one onion." But I didn't have time. Amanda Seyfried was begging to change my diaper... (1,001 of 4,625)

...another Christmas miracle. Mistletoe, stockings, sleigh bells, snow! All these things I have put up my ass. The taste of coffee... (2,974 of 4,625)

...I felt a *very* cold finger on my cheek and I turned around and I said, "Grandma?" and she goes, "Surprise, I'm alive and I work at Sears!" I said, "okay"... (3,047 of 4,625)

OK winger wonderland story time boys & girls.

1. Sleet stops, it's warming up, neighbor decides get out & drive, probably after seeing some truck drive down our residential road (4-wheel drive). Neighbor has new SUV push button start, 2-wheel drive, which is NOT THE SAME THING.

2. So anyway, they back out of their garage & then pull forward down their driveway. The driveway is flat, but it's also a really really long driveway that goes from the back of the house down the side of the house. This will be important later.

3. They make it down the driveway just fine, so now super confident this will go well.

They pull out on our little residential road and start driving.

Mother nature is laughing her ass off right about now.

4. I should mention the roads through our little subdivision don't have curbs or sewers. We're basically out in the country so they just slope roads so the run-off goes into a ditch at the side of the road.

5. So anyways, their SUV starts to slightly fishtail. They haven't gone far at this point. So, they stop, and the SUV, although stopped, just ever so slowly slides to the side of the road and ends up half way in the ditch & almost tipped over.

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10