Ram Mandir, Donation or Extortion : A thread

These saffron clad people came to my home and my dad being himself asked these extortionists for their details when they stepped inside my house, to which they harshly said they were Karsevaks, while asking my dad his name, gotra etc.

I have been working on pandemic outbreaks for 15 years.

There is a misunderstanding of the difference between the response in much of the West, versus successful countries (including New Zealand and Australia).

Summarizing:

1.Reactive versus proactive and goal oriented.

1/-

2.Mitigation (slowing transmission) versus elimination (stopping transmission)

3.Gradually responding to increasing levels of infection by imposing greater restrictions which enables the infection rate to grow (red zone strategy), …

2/

versus starting with high restrictions to arrest transmission and relaxing restrictions only when the number of new cases is so low that contact tracing or localized short term action can stop community transmission (green zone strategy, including localized "fire fighting").

3/

4.Trying to keep economic activity and travel as open as possible but perpetuating the economic harm and imposing yoyo restrictions, versus making an initial sacrifice of economic activity and travel in order to benefit from the rapid restoration of normal economic activity.

4/

5.Focusing attention on few individuals resistant to social action because of shortsightedness or selfishness, versus recognizing the vast majority do the right thing if given clear guidance and support, which is what matters for success, as elimination is a robust strategy.

5/

I've been wanting to write this thread for a while. It has been inspired by hearing a common thought: why can't people just "listen"? If people just followed the rules, we wouldn't be in this mess. I think this is oversimplification of the problem with COVID: 1/

It is true, there are people who haven't been following guidelines (by definition that happened a LOT at Christmas/NYE in my region), but even before, we know transmission in private gatherings happens. 2/

These private gatherings are pictured to be big raucous parties, but in reality, even before lockdown, this is just people having dinner, watching TV, doing things we did before on a daily basis. These little ripples when added across the country make a big wave.. 3/

...and little can be done about this apart from positive messaging. You can't very well have police patrolling neighbourhoods across the country. 4/

Next thing is we keep hearing over and over and over, stay home. There are diminishing returns with this advice, but also, most people who can stay home ARE. So what's the issue? There are a HUGE # of people who can't stay home because they work in essential jobs 5/

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10

My wonderful @jainfamilyinst colleagues @laura_bmw & @Edi_Nilaj have released their new report "Student Debt and Young America," which pretty comprehensively demolishes many of the myths about who does and doesn't have student debt.
https://t.co/y02KFosRQ3
Highlights to follow
/1

@laura_bmw @Edi_Nilaj First of all, look at this one chart that tells you why the student debt crisis is happening: rising debt; stagnant income, and the gap has opened widest for minority borrowers.
/2

You look at that chart and you see the total failure of the human capital model to explain labor market outcomes, insofar as it even is a falsifiable social science hypothesis.
/3

Second, while it's true that total loan balances are increasing in income, student debt has increased most over time among the lowest-income groups. This tells you that student debt is becoming a marker of the disadvantaged rather than the advantaged.
/4

Third, balances on outstanding loans are rising over time, not declining. As I said in my last report, the student debt crisis is a crisis of non-repayment. This is why it's foolish to think the student debt is ever going to be paid back, whether it's cancelled now or not.
/5