Amazing news. Our team @JennerInstitute are so pleased to see this!
A few quick responses to some pointing out it could be even better (more/cheaper/single-dose) 1/
The first shipment of 1 million doses of the #OxfordAstraZeneca vaccine from the @SerumInstIndia is on the way to @ortambo_int
— South African Government (@GovernmentZA) January 31, 2021
The shipment left the Chhatrapati Shivaji Maharaj International Airport in Mumbai today and will arrive in South Africa on 1 February 2021.#COVID19 pic.twitter.com/lTw1EtGi0d
We & @AstraZeneca worked all year in anticipation of this scarcity & nationalism. We developed a strategy which gives as many countries / regions as possible control over their own supply AND aims to provide vaccine for export. 2/
— Sandy Douglas (@sandyddouglas) January 30, 2021
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1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 30, 2021
"we generated a mouse model expressing hACE2 by using CRISPR/Cas9 knockin technology. In comparison with wild-type C57BL/6 mice, both young & aged hACE2 mice sustained high viral loads... pic.twitter.com/j94XtSkscj
@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2
1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 2, 2021
2 papers:
Human\u2013viral molecular mimicryhttps://t.co/irfH0Zgrve
Molecular Mimicryhttps://t.co/yLQoUtfS6s https://t.co/lsCv2iMEQz
@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
https://t.co/9Z4oJmkcKj
@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
https://t.co/I90OOCJg7o