my adhd coping mechanism is I talk to tens of thousands of people so they'll follow me back, then I livetweet my daily activities and get that lil dopamine hit or whatever when they click the heart when I type "ok just sent that email I been procrastinating on"

when I was a teenager, the dominant criticism my closest friends had of me was that I was too arrogant, and they were right. I was too caustic, abrasive, eager to nitpick, quick to criticize, and I was way too certain of myself. I spent my entire 20s trying to correct for this

the social niceties stuff were relatively trivial for me to address. learning to be gracious, patient, I could manage all of that. But "too certain of oneself" goes order of magnitudes deeper. It goes into philosophical territory about risk, certainty, the nature of knowledge

I very seriously experimented with beliefs like "almost everything I know is wrong to a degree I do not understand", "my mental models are contaminated beyond repair", "I have been indoctrinated and need to be deradicalized", I subjected myself and my mind to radical rewrites

Over 8+ years I wrote over 800,000 words of introspective journaling, investigating my own mind, investigating the investigator. I read & talked to thousands of people from around the world to seek out different ways of thinking, seeing, being, believing, knowing, understanding

I tried to think of myself as a robot that needed debugging. I actually made substantial progress with that

I tried to think of myself as a garden that needed tending. I made substantial progress with that

I tried not to think of myself at all, and I transcended progress itself

The courage to be disliked, Ichiro Kishimi and Fumitake Koga. Heard good things, let’s dig in

Youth tells philosopher, life is hard and complicated and full of struggle. Philosopher says life is simple. Debate ensues

They discuss the subjectivity of water temperature - 18deg is cool when weather is hot, warm when weather is cold. No escape from your own subjectivity

P: Instead of lamenting about the world’s darkness, you could just remove the dark glasses.

Y: people cannot change. I am suffering because of my inability to change

Narrator: why is Y like this, so determined to refute P? Feelings of inferiority, self-pity, self-consciousness

Y: people want to change precisely because they can’t

P: why are you so adamant about this

Y: I have an incel friend

P: why do you think he can’t go out?

Y: background?

P: so cause and effect? determinism?

Y: ya

P: if determinism were true, wouldn’t everyone be incel

🤔

Y: so u saying past doesn’t matter

P: aye

Y: so there’s no explanation why my friend can’t go out?

P: your friend is insecure so he can’t go out. Flip it: he doesn’t want to go out, so he’s creating the anxiety.

Y: ridiculous. You’re saying he’s pretending to be sick

P: no

Nearly a year ago, the Tablighi Jamaat controversy took over India’s media. Around 3,500 foreign nationals had visited India to attend the Tablighi Jamaat event at the Nizamuddin Markaz Mosque in Delhi.

With the lockdown being announced on March 24, 2020, several attendees had moved to different parts of the country to attend smaller gatherings in local mosques.

Around 960 foreign nationals were held at quarantine and in states like UP, Jharkhand, Maharashtra, Karnataka, etc. were sent straight to prison.

There was an outpour of Anti-Muslim bigotry in much of Indian news media with this event where it ramped up its demonisation of the community.

For weeks, the attendees of the Tablighi Jamaat event were named the “super-spreaders” of COVID and in several cases, Maulana Mohammad Saad was called a terrorist and “the maulana of death”.

For those traveling to DC on Jan. 6th, I'm a native to the area and I would like to share with you what I will be doing this time and what I have done for the last two rallies...1/

Overall I think Labour will be a bit disappointed with how the ‘relaunch’ has started. Labour have given themselves a mountain to climb anyway through a year of inaction but the speech today lacked coherence, purpose and distinction from the government.

Starmer is (funnily enough) making a lot of the same mistakes Corbyn made in 2019. He is listing a ‘bold’ set of policy proposals that come across as disjointed and lacking connection to Britain’s priorities.

The policies themselves were basically good, I wouldn’t argue against them. But I would cringe whenever Labour came out with spending proposal after spending proposal in 2019 without any rationale or connection to a larger economic strategy. That’s what Starmer did today.

The questions that voters will have about Starmer’s speech are the same ones that voters will have had about Corbyn’s 2019 manifesto: why are these policies your priority, how can we afford them and why aren’t we doing these already?

The first one needs to be answered by diagnosing Britain’s problems and their causes. He doesn’t have to diagnose all of them. For the purpose of today he could have picked three that feed off each other: inequality, stagnant income growth and stagnant productivity.

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10