Thread on F Tender by CM's Highways Dept: 2 events happened over d last month. A Contractor calls me & says not to proceed on Corruption in Rs 494 Cr Tender. A day b4 opening of Rs 494 Cr tender, 2 ppl come to our office in d guise of inviting me to a rotary event.

So, I want to talk about how sexual harassment and fair pay are linked at Google (and beyond), because I think that's an angle that isn't being highlighted enough in the coverage of these walk-outs. I'm going to frame it largely around my personal experience there. Thread.

When I was sexually harassed by the director of the area I was working in, I was afraid to report it because I was worried that "getting him in trouble" would result in the subtle retaliation of missed leadership opportunities.

I wanted to continue working on the team I was on, because I'd gained a lot of very deep knowledge and expertise in that area, as well as reputation and camaraderie with the other folks working in that area. I didn't want to make the situation more "difficult."

To get promoted at Google, several need to happen: 1. you need opportunities for ownership and leadership above your current level (basically, opportunities to show you're working at the next level you're trying to get promoted to). The work you're "assigned" has a big impact.

2. You need glowing reviews from peers, *at or particularly above the level you're hoping to get promoted to.* Basically, you need people a lot more senior than you to say you're doing awesome work.

We are all products of our own environments. Our environments shape our character, our personality, our habits, our identity.

The environment that Ousmane Dembélé grew up in and the environment that FC Barcelona seeks to engulf its youngsters with could not be more different.

The Great Gatsby starts with a life lesson.

"Whenever you feel like criticizing any one, just remember that all the people in this world haven't had the advantages that you've had."

Ousmane hasn’t had the advantages that La Masia youngsters have had. That’s why he’s Ousmane.

Like every La Masia youngster, Ousmane grew up with a dream: playing for Barça.

Like every youngster, he fought to stand out amid a talented group of players, the majority of which would fail to go pro.

However, his football education was the polar opposite to that of La Masia.

Ousmane did not reside in one of the most expensive academies in Europe: he lived in a low-cost public housing unit in Normandy. He did not play in the well-trimmed pitches of La Masia, he played in the concrete jungles of Évreux. These disadvantages made him the man he is today.

While street soccer encourages individuality & creative freedom, academy-based training like La Masia encourages unselfishness & teamwork.

That’s why Barça produce certain types of 20-year-olds like a factory line. It’s also why Barça spent €145m on a 20-year-old Ousmane.

My dad’s first memory is hiding under a table 80 years ago tonight, when Nazis took his dad to Dachau on #Kristallnacht.

His parents, my Omi and Opi, always considered themselves more German than Jewish, so they didn’t think they’d get swept up in the madness.

Opi was taken to city hall with other Jews and lined up against a wall. He thought he was going to be shot.

He always remembered when they got to Dachau there were pajamas with Jewish stars waiting on their cots. Obviously not a spontaneous thing.

He was very lucky. His family got him a fake Uruguayan visa and he was out of Dachau six weeks later. “Before Christmas,” my dad recalls.

@avacta's AVA6000 approved by MHRA. Superb news. First dosing 'around mid-year'; first data to come within 3-4 months after that.

A summary thread on the significance of AVA6000 - and #AVCT's pre CISION platform as a whole - to both the oncology industry and to AVCT itself. 1/10

In very basic terms, #AVCT's pre CISION chemotherapies are essentially reformulated versions of existing, approved chemotherapies that have been used on cancer patients for many years - decades, even.

The pre CISION tech is simply an attempt to improve the safety profile... 2/10

...of the chemo.

Most therapeutics going through clinical trials look for an improvement of at least 20% over the existing industry-standard drug. A 50% increase in efficacy would usually be considered an astonishing result.

In pre-clinical mouse models for #AVCT's AVA6000 3/10

...18 times more pro-doxorubicin was found in the tumour than in the heart. Compare that to the 1:1 ratio of the standard doxorubicin.

What this means is that the pre CISION tech could be used to enable the giving of doses to patients that are multiple times more potent... 4/10

...than standard chemotherapy drugs - either in the form of greater number of cycles of chemo, or in the potency of the individual dose.

For example, in #AVCT's pre-clinical trials, pro-dox (AVA6000) doses were 6x more potent than the standard dox doses.

The results? The...5/10