BC SCIENCE
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They think legit scientists are stupid, too.

Highlight reel-

REAL scientists examine the (non-)science behind the "Official", Corman-Drosten et al Report-

External peer review of the RTPCR test to detect SARS-CoV-2 reveals 10 major scientific

 ...at the molecular and methodological level: consequences for false positive results.

1) all components of the presented test design were cross checked, 2) the RT-qPCR protocol-recommendations were assessed w.r.t. good laboratory practice, and 3) parameters examined against...
...relevant scientific literature covering the field.

The published RT-qPCR protocol for detection and diagnostics of 2019-nCoV and the manuscript suffer from numerous technical and scientific errors, including insufficient primer design, a problematic and insufficient...
...RT-qPCR protocol, and the absence of an accurate test validation.

Neither the presented test nor the manuscript itself fulfills the requirements for an acceptable scientific publication. Further, serious conflicts of interest of the authors are not mentioned. Finally,...
...the very short timescale between submission and acceptance of the publication (24 hours) signifies that a systematic peer review process was either not performed here, or of problematic poor quality. We provide compelling evidence of several scientific inadequacies,...
...errors and flaws.

Considering the scientific and methodological blemishes presented here, we are confident that the editorial board of Eurosurveillance has no other choice but to retract the publication.

There are ten fatal problems with the Corman-Drosten paper which...
... we will outline and explain in greater detail in the following sections.

The first and major issue is that the novel Coronavirus SARS-CoV-2...is based on in silico (theoretical) sequences, supplied by a laboratory in China [1], because at the time neither control material...
...of infectious (“live”) or inactivated SARS-CoV-2 nor isolated genomic RNA of the virus was available to the authors. To date no validation has been performed by the authorship based on isolated SARS-CoV-2 viruses or full length RNA thereof. According to Corman et al.:
...“We aimed to develop and deploy robust diagnostic methodology for use in public health laboratory settings without having virus material available.”

The focus here should be...a) development and b) deployment of a diagnostic test for use in public health laboratory...
...settings. These aims are not achievable without having any actual virus material available (e.g. for determining the infectious viral load).

...only a protocol with maximal accuracy can be the mandatory and primary goal in any scenario-outcome...Critical viral load...
...determination is mandatory information, and it is in Christian Drosten’s group responsibility to perform these experiments and provide the crucial data.

...these in silico sequences were used to develop a RT-PCR test methodology to identify the aforesaid virus. This model...
...was based on the assumption that the novel virus is very similar to SARS-CoV from 2003 as both are beta-coronaviruses.

The PCR test was therefore designed using the genomic sequence of SARS-CoV as a control material for the Sarbeco component; we know this from our...
...personal email-communication with [2] one of the co-authors of the Corman-Drosten paper. This method to model SARS-CoV-2 was described in the Corman-Drosten paper as follows:

“the establishment and validation of a diagnostic workflow for 2019-nCoV screening and specific...
...confirmation, designed in absence of available virus isolates or original patient specimens. Design and validation were enabled by the close genetic relatedness to the 2003 SARS-CoV, and aided by the use of synthetic nucleic acid technology.”
I'll leave the rest 4 U presumably, as outraged as I am readers, to make your own discovery of the shoddy workmanship of this "report", that's being used around the world to justify the horrendously extreme measures of 2020, & beyond, unless we resist w/ every fiber of our being.
@threadreaderapp unroll

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same thing happened in Boston in another immunocompromised person that was sick for 155 days.

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4) Doctors were shocked to find virus has evolved many different forms inside of this one immunocompromised man. 20 new mutations in one virus, akin to the #B117. This is possibly how #B1351 in South Africa 🇿🇦 and #P1 in Brazil 🇧🇷 also evolved.


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Quite a surprise. Ferguson isn’t qualified to comment on such things. He lacks understanding of basic biological concepts, partly explaining why his predictions are often so extreme.


That said, I’ll take him as an ally. It’s clear we’re already at herd immunity. How can I be sure? London had a huge peak of excess deaths in spring. The timing of peak deaths showed clearly that the pandemic was self-limiting. Recall much debate about whether the interval...

...between lockdown & peak deaths was long enough for lockdown to have been the cause of reducing deaths? The answer was “no”. But it was close & I can understand people thinking “well, it’s close, so perhaps it was lockdown that did it?”, thereby establishing a foundational...

...myth favoured by those who genuinely believe lockdown saves lives (it clearly doesn’t).
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In blue are the 30 trusts with the earliest date of peak deaths in spring. In red, the 30 with the latest peak deaths. For me, this is proof that national lockdown, which began Mar 23, played no role whatsoever in turning the pandemic. You’ll see some areas had peak daily...
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Solara Active Pharma Science con call was today at 3:30 PM.

@Gautam__Baid @unseenvalue @drprashantmish6 @rdkriplani

Here are the key takeaways of the call. 👇🧵

Business Updates:

• Speed of filing products has been increased. Filed 5 new DMFs – 3 in US and 2 in EU
• Currently ramping up the facility in VIZAG with strong customer attraction, and will be commercialized as planned in Q3
• VIZAG EBIDTA growth guidance changed to 40%+ YoY

• Growth Driver: Broad based growth in other products and Vizag.

• PLI: Company has filed Mysore for PLI scheme for 1 molecule.

• Technology: Company is about to complete its 2 out of 3 technology, which will enhance efficiency for Solara.

Demand in some of sectors is moderated:
• Mgmt expected moderation in demand, hence company has taken necessary steps for those products.

Gross Margins:
• It was down a bit due to product mix however.

Fiscal 2022:
• Solara has grown in regulated market space.
• Vizag will kick in. CRAMS will support tailwind.
• Most of the CRAMS is commercial API.

• Most of the product is expected to be stable both in term of demand and price in the coming few quarter
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Heres the story of how I volunteered to be infected with 50 parasitic worms (hookworm) for a year as part of a research study. Check out this thread & follow me for more #parasite & marine biology content [t]
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1st some background on the parasites I got. Hookworms are blood-feeding nematodes that live in the intestine of mammals including cats, dogs & humans. ~500 million people are infected with hookworm, mostly in tropical and subtropical areas including the southern USA

Infection with many worms (100+) can cause anemia, which is most problematic in kids, pregnant women, and the elderly. This clinical study was launched to try to develop a vaccine against hookworms to prevent infection

People become infected when baby worms living in the soil penetrate their skin. Baby worms hatch from eggs that infected people poop out. Where plumbing is scarce, poor waste disposal is a common source of heavy infections (100s to 1,000s of worms)

I volunteered to be vaccinated with an experimental hookworm vaccine (I was also paid). After vaccination, the vaccine (or placebo idk) was tested by infecting me with 50 hookworms (Necator americanus) that penetrated my skin from a patch of gauze I wore on my wrist for 1 hour
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