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Current science clear #bced plan unsafe for employees.

What is fiduciary duty? Trustees? #bcpoli @sd5sek00tenay

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 Current science clear #bced plan unsafe for employees.

What is fiduciary duty? Trustees? #bcpoli @RMSD6

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Current science clear #bced plan unsafe for employees. Current science says masks, distancing, ventilation needed. Children transmit & are asymptomatic.

What is fiduciary duty? Trustees? #bcpoli @SD8KootenayLk

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Current science clear #bced plan unsafe for employees. Current science says masks, distancing, ventilation needed. Children transmit & are asymptomatic.

What is fiduciary duty? Trustees? Supers? #bcpoli
@terrytaylorsd10
Current science clear #bced plan unsafe for employees. Current science says masks, distancing, ventilation needed. Children transmit & are asymptomatic.

What is fiduciary duty? Trustees? Supers? #bcpoli

@SD20kc
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Current science clear #bced plan unsafe for employees. Current science says masks, distancing, ventilation needed. Children transmit & are asymptomatic.

What is fiduciary duty? #bcpoli
@RichmondSD38
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Current science clear #bced plan unsafe for employees. Current science says masks, distancing, ventilation needed. Children transmit & are asymptomatic.

What is fiduciary duty? Trustees? Supers? #bcpoli
@ChilliwackSD33

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Current science clear #bced plan unsafe for employees. Current science says masks, distancing, ventilation needed. Children transmit & are asymptomatic.

What is fiduciary duty? Trustees? Supers? #bcpoli
@AbbotsfordSD
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Current science clear #bced plan unsafe for employees. Current science says masks, distancing, ventilation needed. Children transmit & are asymptomatic.

What is fiduciary duty? Trustees? Supers? #bcpoli

@LangleySchools
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Current science clear #bced plan unsafe for employees. Current science says masks, distancing, ventilation needed. Children transmit & are asymptomatic.

What is fiduciary duty? Trustees? Supers? #bcpoli
@Surrey_Schools

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Current science clear #bced plan unsafe for employees. Current science says masks, distancing, ventilation needed. Children transmit & are asymptomatic.

What is fiduciary duty? Trustees? Supers? #bcpoli
@newwestschools
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Current science clear #bced plan unsafe for employees. Current science says masks, distancing, ventilation needed. Children transmit & are asymptomatic.

What is fiduciary duty? Trustees? Supers? #bcpoli
@burnabyschools
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Current science clear #bced plan unsafe for employees. Current science says masks, distancing, ventilation needed. Children transmit & are asymptomatic.

What is fiduciary duty? Trustees? Supers? #bcpoli
@sd43bc
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Current science clear #bced plan unsafe for employees. Current science says masks, distancing, ventilation needed. Children transmit & are asymptomatic.

What is fiduciary duty? Trustees? Supers? #bcpoli
@deltasd37

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Current science clear #bced plan unsafe for employees. Current science says masks, distancing, ventilation needed. Children transmit & are asymptomatic.

What is fiduciary duty? Trustees? Supers? #bcpoli
@VSB39
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Current science clear #bced plan unsafe for employees. Current science says masks, distancing, ventilation needed. Children transmit & are asymptomatic.

What is fiduciary duty? Trustees? Supers? #bcpoli
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Extremely excited today to reveal the first of two great works (magnus opera?), just posted on bioarxiv, applying regulatory network analysis techniques to PDAC expression data to dissect the underlying biology of the disease. Tweetorial time! 1/

Eight years ago I launched an enduring collaboration with Andrea Califano @ColumbiaCancer to apply his regulatory network analysis techniques to #pancreaticcancer. So many amazing scientists have contributed to this work: @paslaise @hc_maurer @AlvaroCurielGa1 @ElyadaEla 2/

What is “regulatory network analysis”? At it's heart, it's a way of extracting more useful information from expression profiles. A fundamental flaw of differential gene expression (DGE) analysis is the assumption that each gene is independent. Biologist KNOW this is not true! 3/


DGE treats all ~25K detectable genes as SEPARATE variables, performs 25K T-tests, and then slaps on a multiple hypothesis correction to make the statisticians less dyspeptic. There is no consideration of the relationships between genes! 4/

Yet we KNOW genes are co-regulated in SETS by transcription factors and other REGULATORY FACTORS. Biologist: “p21 is a target of p53”. DGE: “Shhhh”. These relationships are completely ignored by expression analysis. THIS IS A TRAVESTY! 5/
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Jimmy Bernot PhD \U0001f990\U0001fab1\U0001f3f3\ufe0f\u200d\U0001f308
Jimmy Bernot PhD 🦐🪱🏳️‍...
@JimmyBernot
Heres the story of how I volunteered to be infected with 50 parasitic worms (hookworm) for a year as part of a research study. Check out this thread & follow me for more #parasite & marine biology content [t]
#ScienceTwitter
imgs: https://t.co/hH5YsfS0ay https://t.co/kVurE6BbTS


1st some background on the parasites I got. Hookworms are blood-feeding nematodes that live in the intestine of mammals including cats, dogs & humans. ~500 million people are infected with hookworm, mostly in tropical and subtropical areas including the southern USA

Infection with many worms (100+) can cause anemia, which is most problematic in kids, pregnant women, and the elderly. This clinical study was launched to try to develop a vaccine against hookworms to prevent infection

People become infected when baby worms living in the soil penetrate their skin. Baby worms hatch from eggs that infected people poop out. Where plumbing is scarce, poor waste disposal is a common source of heavy infections (100s to 1,000s of worms)

I volunteered to be vaccinated with an experimental hookworm vaccine (I was also paid). After vaccination, the vaccine (or placebo idk) was tested by infecting me with 50 hookworms (Necator americanus) that penetrated my skin from a patch of gauze I wore on my wrist for 1 hour
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Eric Feigl-Ding
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JUST ONE PERSON—UK 🇬🇧 scientists think one immunocompromised person who cleared virus slowly & only partially wiped out an infection, leaving behind genetically-hardier viruses that rebound & learn how to survive better. That’s likely how #B117 started. 🧵 https://t.co/bMMjM8Hiuz


2) The leading hypothesis is that the new variant evolved within just one person, chronically infected with the virus for so long it was able to evolve into a new, more infectious form.

same thing happened in Boston in another immunocompromised person that was sick for 155 days.

3) What happened in Boston with one 45 year old man who was highly infectious for 155 days straight before he died... is exactly what scientists think happened in Kent, England that gave rise to #B117.


4) Doctors were shocked to find virus has evolved many different forms inside of this one immunocompromised man. 20 new mutations in one virus, akin to the #B117. This is possibly how #B1351 in South Africa 🇿🇦 and #P1 in Brazil 🇧🇷 also evolved.


5) “On its own, the appearance of a new variant in genomic databases doesn’t tell us much. “That’s just one genome amongst thousands every week. It wouldn’t necessarily stick out,” says Oliver Pybus, a professor of evolution and infectious disease at Oxford.
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Localized Surface Plasmon Resonance - an overview | ScienceDirect Topics

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In some cases, almost 100% of the light energy can be converted to the second harmonic frequency. These cases typically involve intense pulsed laser beams passing through large crystals, and careful alignment to obtain phase matching.
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It was great to talk about reproducible workflows for @riotscienceclub @riotscience_wlv. You can watch the recording below, but if you don't want to listen to me talk for 40 minutes, I thought I would summarise my talk in a thread:


My inspiration was making open science accessible. I wanted to outline the mistakes I've made along the way so people would feel empowered to give it a go. Increased accountability is seen as a barrier to adopting open science practices as an ECR

It also comes across as all or nothing. You are either fully open science or your research won't get anywhere. However, that can be quite intimidating, so I wanted to emphasise this incremental approach to adapting your workflow

There are two sides to why you should work towards reproducibility. The first is communal. It's going to help the field if you or someone else can reproduce your whole pipeline.


There is also the selfish element of it's just going to help you do your work. If you can't remember what your work means after a lunch break, you're not going to remember months or years down the line
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8 March 1679 - The date on which 300 saffron clad warriors gave their life to protect temples from mugal army. Thread➡️
Aurangzeb's huge army, which was adorned with artillery, elephant and horses, under the leadership of Commander Darab Khan had marched to punish the ruler of/1


Khandela Raja Bahadur Singh, who became a rebel due to the anti-Hindu policies of Aurangzeb, and to destroy the temples of Shekhawati. Bahadur Singh to compete with such a large army, vacated Khandela for the purpose of conducting guerilla warfare and went Kot Sakrai /2

located in the inaccessible hills of Sakrai. People of Khandela also vacated Khandela and hid in nearby villages.

But some Shekhawat warriors did not like this as they knew that the royal army would not leave a single temple located in Shekhawati unbroken./3

so soon the teams of self-sacrificing Dharma-protectors Shekhawat heroes started reaching Khandela to protect the Dev temples.

Sujan Singh Shekhawat, the young thakur of Chhapoli, was coming back from his wedding when he heard about the imperial army from Shepherds./4

झिरमीर झिरमिर मेहा बरसे,मोरां छतरी छाई |
कुल में है तो आव सुजाण, फोज देवरे आई ||

if you are born in your glorious clan, then come, the army have come to destroy temple. /5
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AGAMA SHASTRA:THE SCIENCE BEHIND THE MARVELS OF HINDU ARCHITECTURE

Agama Shastra is a Sanskrit word that means the manual for worship, temple building, rituals etc in Hindu Tradition.From Sanskrit,agama means handed down by tradition and Shastra means a commentary or treatise.


Therefore, Agama Shastra is a collection of ideas that drafts the rules for worship, temple construction, spirituality and rituals. It has been a guideline for many Hindus from ancient times. It's a collection of Sanskrit, Tamil and Grantha scriptures that mostly contains...


...methods of temple construction, idol creation, philosophical doctrines and meditative practices. It came into being after years of assimiliation and from a variety of sources. Some parts of it are pre-vedic while some are post-vedic.


Hindu Temples are not just temples, they are the pride and identity of Hindus. They are the symbols of Hindu unity and their religious aspirations. Temples are the places of spiritual healing and are our connection with the creator almighty.


Temples are the priceless treasure of our History, Heritage ,Art & Architecture. Architecture that mesmerises and spell bounds you. And Agama Shastra is that very text which is responsible for such a mesmerising and spell binding quality and beauty of our Hindu Temples.
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Engineer Who
Engineer Who
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A long but must read thread. Udaybhan Rathore and myth making in Maratha history: An analysis. This is the thread on Udaybhan Rathore, who he was and how over the time period, his life was portrayed in maratha chronicles and pseudo history. (1/n)

Udaybhan rathore was the head of Bhinai thikana (84 villages) in Ajmer. He was the direct descendant of the famous Rao Chandrasen, Raja of Marwar (4th generation) who resisted Akbar all his life and never made any alliance with mughals like Maharana Pratap. (2/n)

Later in 1783, Maharaja of Jodhpur gave title of Raja to Bhinai family for their military service. Bhinai family and their direct descendant Raja Sh Mayuraj Singh still lives in Ajmer. Anyway coming to Udaybhan Rathore and story of Tanaji. (3/n)

Jai Singh's march on Shivaji and treaty of Purandar (1665) is a well known episode to repeat here. After getting the hill forts from Shivaji under the treaty, Jai Singh didn't have enough man-power to man every one of the small forts because of his next (4/n)

campaign against Bijapur. Jai Singh personally took over a couple of important forts like Kondhana (Sinhgarh), Purandar etc. Others were given to some mughals or their fortification walls destroyed. Jai Singh died in 1667 near Burhanpur while enroute to the north. (5/n)
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Jaya_Upadhyaya
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ADI SHANKAR AND SRI TOTAKACHARYA

Adi Shankaracharya chose his disciple Totakacharya to be the first head of the Math at Joshimath.
The Narsingh Mandir (Mandir of Sri Narasimha) in Joshimath is one of the 108 Divyadesams and also the home of Badrinath during the winter months.


Totakacharya was earlier a boy named ‘Giri’ and a devout disciple of Adi Shankaracharya. Unlike others, he was not known to be an expert in Shastras but his dedication to his Guru was complete and he used to listen to His discourses with utmost faith and devotion.
@SriRamya21


One morning as Adi Shankara and his disciples were getting ready for the discourse, Giri was delayed. The other disciples urged their Guru to commence the lesson on Bramhsutra Bhashya telling him that Giri would anyway not be able to comprehend its deep meaning.
@RajeAiyer


Adi Shankar responded “नायमात्मा प्रवचनेन लभ्यो न मेधया” – Atman cannot be attained through discourses or mere intellect.
He,then, awakened the supreme knowledge in Giri.
Giri spontaneously composed: श्री शङ्करदेशिकाष्टकम् extolling his Guru’s grace.


Adi Shankaracharya granted sanyasa to Giri and gave him the name Totakacharya.
The story of how Giri became Totakacharya is a great example of the importance of faith and devotion in your Guru and not the mere knowledge of the Shastras.
@DetheEsha
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