1/

(I thought I'd answer you here as it will take several posts and that thread is saturated already)

You know I just had to share. . .

Once again, I'm sharing my thoughts based mostly on the work of Dr. Michael Heiser (Theology, Ancient History. . .

With @franklowery our new study on attributes of T cells that contribute to successful cell therapy in cancer patients in @ScienceMagazine today w/ colleagues @slgoff_SB, @NCI_CCR_SB @theNCI a TL;DR thread on key findings with caveats :) 1/10

has a long history of using tumor infiltrating T cells (TILs) to treat cancers since well.. before I was even born. We analyzed our most successful melanoma ACT trial for cell surface phenotypes in TIL infusion products of patients (aPD1/immunotherapy naive) /2

Surprisingly we found a CD39- TIL subset (CD39-CD69-, DN) associated with ACT-response. TBH we were expecting the opposite (CD39+). We only included CD39 bcz multiple groups (e.g. Simoni et al, 2018) had reported CD39+ as enriching for anti-tumor/neoantigen reactive T cells. /3

CD39- DN TILs RNA/epigenetics resemble stem-like memory progenitors, and in vitro were able to self-renew, and give rise to other CD39+ subsets. OTOH the most dominant subset of patient infusion products were CD39+ CD69+ (DP) and these guys were terminally differentiated.. /4

So, to clarify we specifically analyzed tumor-specific mutation-reactive Tcells. Turns out, ACT-responders had pool of neoantigen-reactive TILs in the CD39- phenotype, while non-responders did not (despite other irrelevant CD39- Tcells) -> not all CD39- T cells are bystanders /5

1/ Today is #BlackHoleFriday, an annual science outreach event that, by complete coincidence I’m sure, is done on #BlackFriday. You’ll read lots of cool stuff about black holes on the hashtag. Here’s mine.

2/ Black holes are weird. Duh. People like to think of them as something like incredibly dense nuggets of stuff that sucks other stuff in. But they’re not like that.

3/ If you squeeze enough mass into a small enough volume, the gravity gets so intense that it’s impossible to escape them *if you get too close*. From far away, though, gravitationally they more or less act like anything with that much mass.

4/ So if the Sun turns into a black hole we wouldn’t get drawn in. In fact, we’d orbit it almost exactly the same way as we do now, though we’d freeze to death pretty rapidly, which, in the end, would still kinda suck.

5/ Black holes get weird *when you get close*. Anything with mass warps space — we feel that warp as gravity! — but black holes stretch space to its limit.

https://t.co/odzm9VTdwZ

Thread for today. /0

It is fashionable for people to create sympathy to the unseen / unknown organisms. The poor things that can't stand up and fight for their own existence.

It makes for a brilliant narrative. It melts your hearts. And you get to play saviour of the oppressed by outraging. /1

But, for most part, such things are also false.

Amazon are the lungs of the world. Never mind that most of the world's oxygen production happens in open oceans. But these are harmless ones. Of course, we all love to maintain forests.

However, some things are sheer scare mongering.

For instance - take this: coral reefs will be permanently gone if mean / median temperatures raise by 1°C ..

But, really - how? Then you get a lecture on how CO2 will affect calcification.

Dig a bit deeper from another angle+

+ and you find that the earth was much much warmer during the age of Dinosaurs. So much so, that we had cold blooded lizards growing to sizes of buildings. Surely, there must have been tons of CO2 then!

And the ocean temps were quite high too.