Did you know that all the nuclear bombs we exploded in the '40s-50s-60s have permanently contaminated all the steel the world has produced since then? All steel in the world is divided into two categories: pre-1945 non-contaminated steel, and post-1945 contaminated steel.

How?

1/ #LBBB generates often a classical pattern on #EchoFirst. The pattern is very distinctive in Tissue Doppler of the septum.

The classical pattern arises from the time lapse of the activation and relaxation of the two walls, creating a pattern of interaction due to a sequence temporal imbalances of the tension between the two walls.

2/ As the septum is activated first, it contracts (shortening - septal flash) without activation of the lateral wall, which stretches. This generates slower pressure build up than a normal IVC, which then is prolonged.

3/ During ejection, the LV volume decreases, so both walls shorten. Tension, however, declines first in the septum, as this was activated first. This leads to a tension imbalance, so the lateral wall continues to shorten, the more relaxed septum stretches.

4/ The stretching of the septum builds up an elastic tension in the septum, which is released as recoil, when tension declines in the lateral wall, showing a post systolic shortening in the septum which is due to elasticity.

The distinction of measuring the time in a scientific manner is achieved only by Bhāratīyas. Time has been measured from the smallest dimension to infiniteness. Even Time is envisioned as God and venerated. Paramēśvara was extolled as ‘Mahākāla’, the very embodiment of Time.

Nārāyaṇa Upaniṣad envisages Nārāyaṇa as ‘Kālaśca Nārāyaṇa:’, the very embodiment of Time, ages ago. The measurement of Time by Bhāratīyas is as ancient as the very God Himself. Count of many future ages has also been done even from very ancient times.

Since these calculations aren't dependent upon the birth & death of any individual, but are done based on astronomical science, they are thoroughly scientific. Unfortunately, during the British rule, the Bhāratīya way of Time measurement was casted as an illusion...

...with an evil intention to establish their command. Though it is 70+ years since independence, blindly time is still measured as BC & AD or CE in this religion-less land without even making any attempt to comprehend the magnanimity of Bhāratīya Time measurement methods.

Time measurement based on inhalation and exhalation : (image)

With @franklowery our new study on attributes of T cells that contribute to successful cell therapy in cancer patients in @ScienceMagazine today w/ colleagues @slgoff_SB, @NCI_CCR_SB @theNCI a TL;DR thread on key findings with caveats :) 1/10

has a long history of using tumor infiltrating T cells (TILs) to treat cancers since well.. before I was even born. We analyzed our most successful melanoma ACT trial for cell surface phenotypes in TIL infusion products of patients (aPD1/immunotherapy naive) /2

Surprisingly we found a CD39- TIL subset (CD39-CD69-, DN) associated with ACT-response. TBH we were expecting the opposite (CD39+). We only included CD39 bcz multiple groups (e.g. Simoni et al, 2018) had reported CD39+ as enriching for anti-tumor/neoantigen reactive T cells. /3

CD39- DN TILs RNA/epigenetics resemble stem-like memory progenitors, and in vitro were able to self-renew, and give rise to other CD39+ subsets. OTOH the most dominant subset of patient infusion products were CD39+ CD69+ (DP) and these guys were terminally differentiated.. /4

So, to clarify we specifically analyzed tumor-specific mutation-reactive Tcells. Turns out, ACT-responders had pool of neoantigen-reactive TILs in the CD39- phenotype, while non-responders did not (despite other irrelevant CD39- Tcells) -> not all CD39- T cells are bystanders /5

1/This is a rant I had with someone while texting, and I thought it would make an interesting thread:

2/ Jim, If you come across any information, I still desire to hear any information on the state of our beleaguered union.

EXPLANATION OF THE EXISTENCE OF DARK MATTER AND DARK ENERGY !

What Is Dark Energy ?

More is unknown than is known. We know how much dark energy there is because we know how it affects the universe's expansion. Other than that, it is a complete mystery.

But it is an important mystery. It turns out that roughly 68% of the universe is dark energy. Dark matter makes up about 27%. The rest - everything on Earth, everything ever observed with all of our instruments, all normal matter - adds up to less than 5% of the universe.

This diagram reveals changes in the rate of expansion since the universe's birth 15 billion years ago. The more shallow the curve, the faster the rate of expansion. The curve changes noticeably about 7.5 billion years ago, when objects in the universe began flying apart as

a faster rate. Astronomers theorize that the faster expansion rate is due to a mysterious, dark force that is pulling galaxies apart.

WHAT OUR SANATAN DHARMA SAYS IN THIS CONTEXT LET’S TAKE A LOOK

The verses of Taittiriya Aranyaka say that only one pada of the Lord

is this manifested universe and the remaining three padas are outside it.

According to the observations and realizations of ancient seers, nearly eighty percent of this universe is yet of unknown nature which remains inactive during the process of creation (rather, evolution).