What are the classics of the "Science of Science" or "Meta Science"? If you were teaching a class on the subject, what would go in the syllabus?
psychological science" from the Open Science Collaboration of @BrianNosek et al. https://t.co/yjGczLZ6Je
(Look at that abstract, wow!)
https://t.co/xduj2A8c8q
A few observations from "The Science of Science", a useful review article appearing in this week's Science: https://t.co/D6DENKF4rS
— Michael Nielsen (@michael_nielsen) March 9, 2018
The book has been in my queue for some time, and is almost certainly a good overview of a huge chunk of economic thinking about science.
Great thread. I\u2019d add Paula Stephan\u2019s book: https://t.co/QdIPBchdym
— David Lang (@davidtlang) January 14, 2021
Twitter threading makes it a little hard to skim the thread. Expandable tree version here, thanks to @paulgb's great treeverse Chrome extension: https://t.co/vF4JF0Gf4J
More from Science
Look like that they got a classical case of PCR Cross-Contamination.
They had 2 fabricated samples (SRX9714436 and SRX9714921) on the same PCR run. Alongside with Lung07. They did not perform metagenomic sequencing on the “feces” and they did not get
A positive oral or anal swab from anywhere in their sampling. Feces came from anus and if these were positive the anal swabs must also be positive. Clearly it got there after the NA have been extracted and were from the very low-level degraded RNA which were mutagenized from
The Taq. https://t.co/yKXCgiT29w to see SRX9714921 and SRX9714436.
Human+Mouse in the positive SRA, human in both of them. Seeing human+mouse in identical proportions across 3 different sequencers (PRJNA573298, A22, SEX9714436) are pretty straight indication that the originals
Were already contaminated with Human and mouse from the very beginning, and that this contamination is due to dishonesty in the sample handling process which prescribe a spiking of samples in ACE2-HEK293T/A549, VERO E6 and Human lung xenograft mouse.
The “lineages” they claimed to have found aren’t mutational lineages at all—all the mutations they see on these sequences were unique to that specific sequence, and are the result of RNA degradation and from the Taq polymerase errors accumulated from the nested PCR process
2) The leading hypothesis is that the new variant evolved within just one person, chronically infected with the virus for so long it was able to evolve into a new, more infectious form.
same thing happened in Boston in another immunocompromised person that was sick for 155 days.
3) What happened in Boston with one 45 year old man who was highly infectious for 155 days straight before he died... is exactly what scientists think happened in Kent, England that gave rise to #B117.
Immunocompromised 45 year old suffered from #COVID19 for 155 days before he died. The virus was changing very quickly inside the man's body\u2014it acquired a big cluster of >20 mutations\u2014resembled the same ones seen in #B117 & #B1351. (NPR audio Part 1 of 2)\U0001f9f5https://t.co/7kWiBZ1xGk pic.twitter.com/ZJ7AExB78Y
— Eric Feigl-Ding (@DrEricDing) February 8, 2021
4) Doctors were shocked to find virus has evolved many different forms inside of this one immunocompromised man. 20 new mutations in one virus, akin to the #B117. This is possibly how #B1351 in South Africa 🇿🇦 and #P1 in Brazil 🇧🇷 also evolved.
2) NPR report audio part 2 of 2:
— Eric Feigl-Ding (@DrEricDing) February 8, 2021
Dr. Li couldn't believe what they found. "I was shocked," he says. "When I saw the virus sequences, I knew that we were dealing with something completely different and potentially very important." pic.twitter.com/HT3Yt6djFd
5) “On its own, the appearance of a new variant in genomic databases doesn’t tell us much. “That’s just one genome amongst thousands every week. It wouldn’t necessarily stick out,” says Oliver Pybus, a professor of evolution and infectious disease at Oxford.
1.
https://t.co/d5NKtNlxxa
Sounds as if its connected to Bill Gates "LUCIFERASE" Vaccine?
2.
https://t.co/k0w1mjaPg0
"HILLARY RODHAM CLINTON SCHOOL OF LAW"
- AT SWANSEA UNIVERSITY!!!
3.
https://t.co/jifuWq6cGq
Remember all those FIRES, over the Summer!!!
4.
https://t.co/H3lstFyYx8
WUHAN PARTNERSHIP
"Links between Swansea & Wuhan date back to 1855 when Swansea missionary Griffith John founded the Wuhan Union Hospital.
This relationship was strengthened when representatives of the two cities signed an agreement".
5.
https://t.co/5b1JqiEQzi
Swansea University Strengthens Links with China