rOxXQRllo5 Some peer-reviewed highlights in this thread 👇

More from Science

Super excited to share my very first lead-author paper in @ScienceAdvances

Supported by @HIRN_CC @NIDDKgov @UFBME @UFWertheim @ufdiabetes @UMCoEDean
Lead by @Cherie_Stabler & @ashu83

link: https://t.co/FbqVWQ0n5p

This is a thread 👇

Highlights:
⚪️A Lab-on-a-Chip platform for organoids w/ wide capabilities: long-term culture | controlled & dynamic perifusion | in situ spatio-temporal imaging | serial cell assessment | ease of sample retrieval

⚪️Continuous fluidic flow increased local oxygen supply to islets in hydrogels & reduced cellular hypoxia
⚪️Flow increased cellular viability & reduced apoptosis & cell death

⚪️Human islets in hydrogels were highly functional during the 10 day in situ culture in our chips, while islet function was rapidly lost under static conditions
⚪️Glucolipotoxicity study showed a treatment window as small as 2.5 hours can elevate cell death

What are organoids? – A miniaturized version of an organ that imitate an aspect of human interface. They are commonly developed from stem cells in a lab. Human body also produces organoids naturally particularly within the pancreas.

$Jimmy Bernot PhD \U0001f990\U0001fab1\U0001f3f3\ufe0f\u200d\U0001f308$

Jimmy Bernot PhD 🦐🪱🏳️‍...
@JimmyBernot

Heres the story of how I volunteered to be infected with 50 parasitic worms (hookworm) for a year as part of a research study. Check out this thread & follow me for more #parasite & marine biology content [t]
#ScienceTwitter
imgs: https://t.co/hH5YsfS0ay https://t.co/kVurE6BbTS

1st some background on the parasites I got. Hookworms are blood-feeding nematodes that live in the intestine of mammals including cats, dogs & humans. ~500 million people are infected with hookworm, mostly in tropical and subtropical areas including the southern USA

Infection with many worms (100+) can cause anemia, which is most problematic in kids, pregnant women, and the elderly. This clinical study was launched to try to develop a vaccine against hookworms to prevent infection

People become infected when baby worms living in the soil penetrate their skin. Baby worms hatch from eggs that infected people poop out. Where plumbing is scarce, poor waste disposal is a common source of heavy infections (100s to 1,000s of worms)

I volunteered to be vaccinated with an experimental hookworm vaccine (I was also paid). After vaccination, the vaccine (or placebo idk) was tested by infecting me with 50 hookworms (Necator americanus) that penetrated my skin from a patch of gauze I wore on my wrist for 1 hour

$Nick Hudson \U0001f642$

Nick Hudson 🙂
@NickHudsonCT

Here is another very enjoyable conversation, with @Pandata19’s scientific advisory board member, Dr Jay Bhattacharya. Key ideas in this thread.

We are making world-changing decisions on the basis of evidence that is not very good. Vast scientific evidence tells us that infection fatality rates are much lower than originally expected. A small fraction of people get severe illness. 2/10

The scientific community has been resistant to evidence not supporting the majoritarian view, preferring instead to gin up panic, focusing on the worst case for everything the virus does & the best case for everything lockdowns do, and ignoring the range of uncertainty. 3/10

Academe is a strange place now, with debate stifled. But there's a sense some are opening up to considering opposing views. This is key, since suppression of views stops knowledge from progressing—the end of science. Public health norms of unified messaging complicate this. 4/10

Why did we, from the start, assume we knew nothing about this virus, instead of assuming a reasonable prior? Low susceptibility was evident early on. Assuming any virus is new is hard to square with our deep-time co-evolution with viruses, & their slow evolution. 5/10

Michael Nielsen
@michael_nielsen

What are the classics of the "Science of Science" or "Meta Science"? If you were teaching a class on the subject, what would go in the syllabus?

Here's a (very disorganized and incomplete) handful of suggestions, which I may add to. Suggestions welcome, especially if you've dug into relevant literatures.

1. The already classic "Estimating the reproducibility of
psychological science" from the Open Science Collaboration of @BrianNosek et al. https://t.co/yjGczLZ6Je

(Look at that abstract, wow!)

Many people had pointed out problems with standard statistical methods, going back decades (what are the best refs?). But this paper was a sledgehammer, making it impossible to ignore the question: what, if anything, were we actually learning from all those statistical studies?

2. Dean Keith Simonton's book "Creativity in Science: Chance, Logic, Genius, and Zeitgeist". If an essentially scientometric book could be described as a fun romp through science & creativity, this would be it

The Tycoon Mindset
@tycoonmindset05

Solara Active Pharma Science con call was today at 3:30 PM.

@Gautam__Baid @unseenvalue @drprashantmish6 @rdkriplani

Here are the key takeaways of the call. 👇🧵

Business Updates:

• Speed of filing products has been increased. Filed 5 new DMFs – 3 in US and 2 in EU
• Currently ramping up the facility in VIZAG with strong customer attraction, and will be commercialized as planned in Q3
• VIZAG EBIDTA growth guidance changed to 40%+ YoY

• Growth Driver: Broad based growth in other products and Vizag.

• PLI: Company has filed Mysore for PLI scheme for 1 molecule.

• Technology: Company is about to complete its 2 out of 3 technology, which will enhance efficiency for Solara.

Demand in some of sectors is moderated:
• Mgmt expected moderation in demand, hence company has taken necessary steps for those products.

Gross Margins:
• It was down a bit due to product mix however.

Fiscal 2022:
• Solara has grown in regulated market space.
• Vizag will kick in. CRAMS will support tailwind.
• Most of the CRAMS is commercial API.

• Most of the product is expected to be stable both in term of demand and price in the coming few quarter

did not explode. It then hit the side of the main gun and then exploded on top of the turret, all in a fraction of a second. Before I knew, it seemed I had received a straight right punch so to say to my chin. I saw some blood appear on my left hand and there was a sharp drop in+

my eyesight.

Lt Colonel (now Lt Gen) Dalbir Singh, then Commanding Officer of 10 Para Commando, who was standing on the engine deck said to me, “Yaar what a close shave.”

He suddenly saw me and the look on his face told me that something was very very wrong with me. In that+

fraction of a second, as if it was a rewind of my entire life, thoughts raced through my life as to how and when I had landed myself in such a situation…

I asked my gunner to pull out a first field dressing (FFD) which is standard equipment in a first aid box carried in each+

$Danielle \U0001f1e7\U0001f1f4$

Danielle 🇧🇴...
@dinkydani21

❤✈️🌎 2 years ago today @JamesIvings and I sold all our belongings and left the UK to travel for a year. We've never been happier and we have no plans to ever return there 🙂

Thread 👇

Since then we've started a remote web dev company @SquarecatWebDev and been lucky enough to have completed several freelance projects 💻 that have kept us on the road.

In the last few months we've become a huge part of this amazing new Maker community and have found so many new friends from @makerskitchen, @women_make_ and several others! 🥰

We love travelling together (even if I'm only a glorified laptop watcher 😒) but we're both much happier being able to share our ideas outside of our own little bubble and our products have benefitted too!

Here's to another year of nomading with my favourite person and to the Maker community continuing to grow with our help! Maybe one day we'll all get to meet each other ✌️ 💛

raina douris
@RahRahRaina

fascinated by this man, mario cortellucci, and his outsized influence on ontario and GTA politics. cortellucci, who lives in vaughan and ran as a far-right candidate for the italian senate back in 2018 - is a major ford donor...

his name might sound familiar because the new cortellucci vaughan hospital at mackenzie health, the one doug ford has been touting lately as a covid-centric facility, is named after him and his family

but his name also pops up in a LOT of other ford projects. for instance - he controls the long term lease on big parts of toronto's portlands... where doug ford once proposed building an nfl stadium and monorail... https://t.co/weOMJ51bVF

cortellucci, who is a developer, also owns a large chunk of the greenbelt. doug ford's desire to develop the greenbelt has been

and late last year he rolled back the mandate of conservation authorities there, prompting the resignations of several members of the greenbelt advisory

$Anu Satheesh \U0001f1ee\U0001f1f3$