- Soren Kierkegaard
- Soren Kierkegaard
- Soren Kierkegaard
- Soren Kierkegaard
The result may be the same, but you won't be. We always grow more through defeats than victories."
- Soren Kierkegaard
- Soren Kierkegaard
- Soren Kierkegaard
- Soren Kierkegaard
But he became more and more quiet until in the end, he realized prayer is listening."
- Soren Kierkegaard
- Soren Kierkegaard
- Soren Kierkegaard
And retweet the first tweet to share with others:
https://t.co/qwSbdnkiZM
15 Deep Philosophy Quotes From \u201cSoren Kierkegaard"
— Andrew Duggan (@ajdduggan) March 7, 2022
| Thread \U0001f9f5 pic.twitter.com/rLXhMgV6PA
More from Andrew Duggan
More from Principles
Shared a lot of wins publicly in 2021, so it feels appropriate to share the losses just as publicly.
Here are my 10 biggest Ls from 2021 (and what I learned from each one):
Dopamine Addiction
Humans were not made for social media—the dopamine hits are dangerous.
I fell victim.
On several occasions, I found myself constantly refreshing my notifications on a viral thread.
It was gross.
I’m learning to physically force separation to avoid it.
Hustle Culture Fail
I spent the better part of the last decade as a hustle culture aficionado.
Then I burned myself out and was totally incapable of thinking creatively.
I made a change. Now I:
• Work like a lion
• Sleep 8 hours
• Take more walks
My life & work have 10Xed.
Solana Fail
I invested in Solana early and was riding high when it hit $30+ in April—10X+ on my investment.
I sold it and thought I was the next Warren Buffett.
Then it hit $100, $200, & $250—as I stubbornly sat on the sidelines refusing to re-enter.
I am not Warren Buffett.
The Hedonic Treadmill
I tweeted this in May—and then failed to practice what I preached.
Every win felt a bit less exciting. It’s part of our biology, but it was no way to live.
Measure internally, not externally.
Here are my 10 biggest Ls from 2021 (and what I learned from each one):
Dopamine Addiction
Humans were not made for social media—the dopamine hits are dangerous.
I fell victim.
On several occasions, I found myself constantly refreshing my notifications on a viral thread.
It was gross.
I’m learning to physically force separation to avoid it.
Hustle Culture Fail
I spent the better part of the last decade as a hustle culture aficionado.
Then I burned myself out and was totally incapable of thinking creatively.
I made a change. Now I:
• Work like a lion
• Sleep 8 hours
• Take more walks
My life & work have 10Xed.
Solana Fail
I invested in Solana early and was riding high when it hit $30+ in April—10X+ on my investment.
I sold it and thought I was the next Warren Buffett.
Then it hit $100, $200, & $250—as I stubbornly sat on the sidelines refusing to re-enter.
I am not Warren Buffett.
The Hedonic Treadmill
I tweeted this in May—and then failed to practice what I preached.
Every win felt a bit less exciting. It’s part of our biology, but it was no way to live.
Measure internally, not externally.
The Hedonic Treadmill is real.
— Sahil Bloom (@SahilBloom) May 21, 2021
Humans have a tendency to quickly return to a baseline level of happiness after positive events.
Step off the treadmill.
Focus on increasing your happiness baseline, not on the height or frequency of the spikes above it.
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK

In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa

Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs

MDZS is laden with buddhist references. As a South Asian person, and history buff, it is so interesting to see how Buddhism, which originated from India, migrated, flourished & changed in the context of China. Here's some research (🙏🏼 @starkjeon for CN insight + citations)
1. LWJ’s sword Bichen ‘is likely an abbreviation for the term 躲避红尘 (duǒ bì hóng chén), which can be translated as such: 躲避: shunning or hiding away from 红尘 (worldly affairs; which is a buddhist teaching.) (https://t.co/zF65W3roJe) (abbrev. TWX)
2. Sandu (三 毒), Jiang Cheng’s sword, refers to the three poisons (triviṣa) in Buddhism; desire (kāma-taṇhā), delusion (bhava-taṇhā) and hatred (vibhava-taṇhā).
These 3 poisons represent the roots of craving (tanha) and are the cause of Dukkha (suffering, pain) and thus result in rebirth.
Interesting that MXTX used this name for one of the characters who suffers, arguably, the worst of these three emotions.
3. The Qian kun purse “乾坤袋 (qián kūn dài) – can be called “Heaven and Earth” Pouch. In Buddhism, Maitreya (मैत्रेय) owns this to store items. It was believed that there was a mythical space inside the bag that could absorb the world.” (TWX)
1. LWJ’s sword Bichen ‘is likely an abbreviation for the term 躲避红尘 (duǒ bì hóng chén), which can be translated as such: 躲避: shunning or hiding away from 红尘 (worldly affairs; which is a buddhist teaching.) (https://t.co/zF65W3roJe) (abbrev. TWX)
2. Sandu (三 毒), Jiang Cheng’s sword, refers to the three poisons (triviṣa) in Buddhism; desire (kāma-taṇhā), delusion (bhava-taṇhā) and hatred (vibhava-taṇhā).
These 3 poisons represent the roots of craving (tanha) and are the cause of Dukkha (suffering, pain) and thus result in rebirth.
Interesting that MXTX used this name for one of the characters who suffers, arguably, the worst of these three emotions.
3. The Qian kun purse “乾坤袋 (qián kūn dài) – can be called “Heaven and Earth” Pouch. In Buddhism, Maitreya (मैत्रेय) owns this to store items. It was believed that there was a mythical space inside the bag that could absorb the world.” (TWX)