A quick thread on the new variant, pulling together information from news sources, twitter, genomic databases, and word from well-placed peers.

The new variant in the UK consists of several mutations in the spike protein, including ΔH69/ΔV70 deletions & other receptor binding domain mutations such as N501Y.

The variant is described here in this pre-print from @GuptaR_lab.

https://t.co/ui2U1r1ANA
The ΔH69/ΔV70 variant continues to increase quite rapidly as a proportion of overall positives (roughly doubling in the last 2 to three days), and is apparently now the dominant strain in test positives in some regions.
Extensive efforts have gone into enhanced surveillance for the ΔH69/ΔV70 deletion with and without RBD mutations, and it is good that we are aware of this.

There is a need for calm and rational thinking, and more evidence is needed.

But the early data is certainly concerning

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Could it be the MSM played a hoax on us? What if the inauguration was prior filmed and aired as “live TV”? Why was sun shining in some while snow/non sun shining falling in some shots? Why bright lights in front of WH? What if CGI was used? Would our media do that? Why?


The “stage” is still there last night👇🏻👀


Why was BiDEn sworn in before noon? The Constitution(Supreme Law of the Land) says noon is time of swearing in.... why did BiDEn sign “17” Executive Orders” which were only blank pieces of paper?

Can a new POTUS be sworn in during time of war? NO! We are at war! Remember Emergency Act in Spring of 2020 signed due to China Bioweapon? Then, EO signed and China election interference. THESE are ACTS of WAR!

Did POTUS Trump sign the Insurrection Act allowing Military to take the reigns of Government control? By law, POTUS does not have to announce it...but if HE does, then he has to physically SHOW the document signed. Could this be why we hear he signed it but have not seen it?
@CarmineSabia Here, let us help @mjs_DC with this thread of Democrats and their propaganda wing who endorsed violence what they dishonestly called "peaceful


@mjs_DC 2)


@mjs_DC


@mjs_DC


@mjs_DC 5)

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The entire discussion around Facebook’s disclosures of what happened in 2016 is very frustrating. No exec stopped any investigations, but there were a lot of heated discussions about what to publish and when.


In the spring and summer of 2016, as reported by the Times, activity we traced to GRU was reported to the FBI. This was the standard model of interaction companies used for nation-state attacks against likely US targeted.

In the Spring of 2017, after a deep dive into the Fake News phenomena, the security team wanted to publish an update that covered what we had learned. At this point, we didn’t have any advertising content or the big IRA cluster, but we did know about the GRU model.

This report when through dozens of edits as different equities were represented. I did not have any meetings with Sheryl on the paper, but I can’t speak to whether she was in the loop with my higher-ups.

In the end, the difficult question of attribution was settled by us pointing to the DNI report instead of saying Russia or GRU directly. In my pre-briefs with members of Congress, I made it clear that we believed this action was GRU.
1/ Some initial thoughts on personal moats:

Like company moats, your personal moat should be a competitive advantage that is not only durable—it should also compound over time.

Characteristics of a personal moat below:


2/ Like a company moat, you want to build career capital while you sleep.

As Andrew Chen noted:


3/ You don’t want to build a competitive advantage that is fleeting or that will get commoditized

Things that might get commoditized over time (some longer than


4/ Before the arrival of recorded music, what used to be scarce was the actual music itself — required an in-person artist.

After recorded music, the music itself became abundant and what became scarce was curation, distribution, and self space.

5/ Similarly, in careers, what used to be (more) scarce were things like ideas, money, and exclusive relationships.

In the internet economy, what has become scarce are things like specific knowledge, rare & valuable skills, and great reputations.