This is a great question, so let's get into this in more detail!
The question here is is essentially, "what did Philip II (father of Alexander) do to the Spartans, and how do we know that?"
A thread! 1/25
Hey I love this and want to send it to someone but I can't find a source for Philip invading them, Wikipedia says he just ignored them?
— Greg Luce (@garglfluz) January 17, 2021
Now we may be skeptical about claims of deliverance, but clearly something happened! 7/25
Plut. Mor. 219F notes Spartan defiance, "When Philip invaded the Peloponnesus" and 218F4 is clear that was a Spartan "war against Philip." 10/25
The Megalopolitans were enemies of Sparta and Plb. is no exception. 13/25
So it seems there was no battle, but just a lot of raiding and then Philip reached some settlement in which significant territory was lost to Sparta. 16/25
17/25
This is an easy passage for the unfamiliar to mess up, because Polybius has more than one Philip to deal with. 18/25
(end/25)
"And he sent a message to Sparta and he said, 'if my army invades Sparta..." and the Spartans responded with just one word, "If."
— Bret Devereaux (@BretDevereaux) January 6, 2021
AND THEN HE DID INVADE THEM, in 338. And they didn't fight, they just gave up and Philip II punked them and took some land.
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Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs