Over the past few days I’ve been speaking to several frontline NHS staff working in hospitals in London and surrounding areas and it seems that the situation is incredibly dire

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One doctor in a London hospital tells me that following a huge spike in cases their hospital is struggling to cope and they now have no choice but to ration Oxygen: “No beds, no space, minimal Oxygen supplies. We’re having to ration Oxygen.”
A senior doctor at one of the biggest London hospitals tells me that all elective surgery has now been cancelled and that roughly 80-85% of beds are currently being used for COVID patients.
At one hospital in London a specific team has been set purely to aid with the patient discharge process. Why? Simply to free up as much bed space as possible because demand is higher than it has ever been.
One medic tells me that the number ITU beds has increased at their hospital as they try and deal with extra demand but they only have staff to cover half of them: “Yes we have extra beds but what is the point if we don’t have any staff to actually work on them?”
Another tells me that so many members of staff are off because they are isolating: “The hospital has no idea what to do with deployment or staffing we’ve all been asked to cancel annual leave and any days off we had because there are so many people who can't come to work”.
I’ve also been told by several members of staff across multiple hospitals that many of their colleagues have signed off due to stress or mental health issues after working flat out this year. Many are saying that they are being drastically overworked and need extra support.
One tells me they have already been working flat out to cover surgeries that had been cancelled “some of us stay after our shifts, we work extra weekends, there’s a huge backlog, so we haven't stopped working.”

Now the latest spike means there will be more to deal with.
Another healthcare professional tells me the different departments at their hospital are being turned into a critical care overflow units and those who have no intensive care training are being asked to help to try and make up the numbers.
If you're a frontline healthcare professional working in hospitals in the UK at the moment, my DMs are open and I really want to hear from you.

Anything you tell me will be dealt with with the strictest of confidence.

More from Health

1/15
Why can cefepime cause neurological toxicity?

And why is renal failure the main risk factor for this complication?

The answer requires us to learn about cefepime's structure and why it unexpectedly binds to a certain CNS receptor.

#MedTwitter #Tweetorial


2/
Let's establish a few facts about cefepime:

🔺4th generation cephalosporin antibiotic
🔺Excretion = exclusively in the urine (mostly as unchanged drug)
🔺Readily crosses the blood-brain barrier (so it easily accesses the brain)

https://t.co/rjYG1BfGPR


3/
The first report of cefepime neurotoxicity was in 1999.

A patient w/ renal failure received high doses of cefepime and then developed encephalopathy, tremors, myoclonic jerks, and tonic-clonic seizures.

✅All symptoms resolved after hemodialysis.

https://t.co/u7JLVitQpp


4/
Cefepime neurotoxicity is surprisingly common, occurring in up to 15% of treated critically ill patients (w/ symptoms varying from encephalopathy to seizures).

💡The main risk factors = renal failure and lack of dose adjustment for renal function.

https://t.co/nxbnzSq8AR


5/
What about cefepime induces neurotoxicity?

One clue is that it's not the only antibiotic that causes neurotoxicity, particularly seizures.

This actually is a class effect w/ other beta-lactam antibiotics (including penicillins and carbapenems).

https://t.co/Lf4BhON9IY

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🌿𝑻𝒉𝒆 𝒔𝒕𝒐𝒓𝒚 𝒐𝒇 𝒂 𝑺𝒕𝒂𝒓 : 𝑫𝒉𝒓𝒖𝒗𝒂 & 𝑽𝒊𝒔𝒉𝒏𝒖

Once upon a time there was a Raja named Uttānapāda born of Svayambhuva Manu,1st man on earth.He had 2 beautiful wives - Suniti & Suruchi & two sons were born of them Dhruva & Uttama respectively.
#talesofkrishna https://t.co/E85MTPkF9W


Now Suniti was the daughter of a tribal chief while Suruchi was the daughter of a rich king. Hence Suruchi was always favored the most by Raja while Suniti was ignored. But while Suniti was gentle & kind hearted by nature Suruchi was venomous inside.
#KrishnaLeela


The story is of a time when ideally the eldest son of the king becomes the heir to the throne. Hence the sinhasan of the Raja belonged to Dhruva.This is why Suruchi who was the 2nd wife nourished poison in her heart for Dhruva as she knew her son will never get the throne.


One day when Dhruva was just 5 years old he went on to sit on his father's lap. Suruchi, the jealous queen, got enraged and shoved him away from Raja as she never wanted Raja to shower Dhruva with his fatherly affection.


Dhruva protested questioning his step mother "why can't i sit on my own father's lap?" A furious Suruchi berated him saying "only God can allow him that privilege. Go ask him"