BC GOVERNMENT
Saved by @CodyyyGardner

THREAD
There’s much debate around the UK's recommended use of the AZ vaccine with a two-dose schedule and flexible timing of second dose. Some thoughts on the AZ recommendation (not Pfizer) based on available data with refs to some excellent threads.

 UK’s MHRA and JCVI are highly-experienced in vaccine assessments and recommendations, and they've surely weighed the benefits & risks of this recommendation carefully. That said, it would be good to see all the data underpinning their recommendation. 2/
https://t.co/NRcHbYxRIw
In general, vaccines should be taken on a schedule tested in an efficacy trial. But it wasn’t possible to conduct the typical dose and schedule optimization prior to these Ph3 trials, and those trials provided valuable data to inform these recommendations. 3/
The UK recommends a two-dose schedule, with the second dose between 4-12 weeks. This *is not* a single dose schedule. Given the data provided, and in the setting of limited supply, overstretched hospitals, and emergence of a more transmissible variant, this seems justifiable. 4/
The UK has important data on the AZ Vx that wasn’t available for Pfizer & Moderna at FDA's VRBPAC, including:
* single-dose efficacy through 4+ months; and
* single-dose immunogenicity (12+ weeks). 5/
https://t.co/vtbviE9VEx
The data shows the AZ vaccine maintains efficacy in the setting of a delayed second dose, although it’s not clear how fast this wanes over time. Delay of the second dose provides a better booster effect as measured by antibody levels, which is seen with other vaccines. 6/
The second dose is important because it can drive a more robust and higher quality antibody response through a process called affinity maturation. It's well-understood that longer intervals can provide a better boost. 7/ https://t.co/cqKIpomUHg
In my view, the immediate priority is prevention of severe disease that drives deaths and the strain on health systems. Efficacy against severe disease is likely better than overall vaccine efficacy. Data after the first dose is promising although the numbers are small. 8/
There’s nothing magic about the (short) 28d interval between doses, which was presumably chosen to ensure rapid onset of protection in Ph3. Vaccine efficacy won't disappear overnight with a delayed 2nd dose - it will wane over time, if at all. Ph3 data supports that concept. 9/
Yes there are risks of waning immunity, non-compliance with the second dose, confusion among the public, etc. Many are implementation considerations that can be addressed with planning and strong communication. 10/
It will be critically important to collect efficacy data around this “flexible second dose” schedule, esp in older adults & against severe disease, to inform licensure and recommendations in countries around the world that are counting on the introduction of this vaccine. 11/
Yes the AZ/Oxford studies had a number of issues, but we must remember that this highly-complex development program was executed in less than a year. And that Pfizer & Moderna's Ph3 execution & vaccine efficacy created very high expectations for all subsequent programs. 12/
The bottom line is that every country needs to make difficult policy decisions with the data they have, not what they'd like to have. There's no perfect answer here, but now that a decision has been taken, the UK can focus on maximizing the benefit and mitigating any risks. 13/

More from Government

Christian Christensen
Christian Christensen
@ChrChristensen
1) This pic published in the Daily Mail showing debris left after terrorist attack on US Capitol seems relatively unremarkable. But a man in Sweden noticed something: the red scarf at the top with the name of the northern Swedish city of Skellefteå. Then it got interesting.


2) The man contacted his local paper, pointing out the fact that there was a scarf from a northern Swedish city of just 70,000 in the debris of the attack. The paper published the story, with the headline: "What's a Skellefteå scarf doing inside of Congress?"


3) It turns out that, in 2017, the scarf had been offered as a Christmas gift from the city of Skellefteå to people who had moved away from the area. They were told go to a website and order one. A total of 934 people did so, and had received the scarf.


4) Now, natl Swedish media picked up story, wondering if a Swede had participated in the terrorist attack in Washington. Doing a search, the paper Dagens Nyheter found pictures of the man who was wearing the scarf. The first showed him trying to force his way into the Capitol.


5) After breaking through the barriers, the scarf man was later seen toward the front of the mob, waiving an American flag, and no longer wearing his baseball hat...but an official police helmet and visor. Skellefteå scarf still on.
GOVERNMENT , CAPITOL ATTACK
\U0001f525Donald Trumpet\U0001f525
🔥Donald Trumpet🔥...
@FROGTrumpet
Declassified:
SELECT COMMITTEE re:ASSASSINATION OF PRESIDENT
JOHN F. KENNEDY
DALLAS, TX., NOVEMBER 22, 1963

John Fitzgerald Kennedy was the fourth victim of Presidential
assassination, preceded by Abraham Lincoln in 1865, James A. Garfield in 1881, and William McKinley in 1901


1. President Kennedy was struck by two rifle shots fired from
behind him.

2.The shots that struck President Kennedy from behind him
were fired
GOVERNMENT
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Larry Schweikart
Larry Schweikart
@LarrySchweikart
1) Where we are: This is much, much bigger than a fraudulent election (it was) or rampant gubment tyrannical China Virus abuse (it is).

2) What we are facing has been building for a good 30 years.

3) I date it back to the GOP failure to defeat Clinton in the gubment shutdown.

4) If you went to public school, that would be the 1995 budget battle.

5) The brand new GOP Congress, with plenty of public support, failed to rein in a Clinton bloated budget.

6) It wasn't the numbers. Compared to today's deficits & debts, this was pocket change. Rather, this was the first time since the Cold War, which was a legit excuse for constant deficit spending, that Congress failed to do its MAIN constitutional duty--oversee spending.

7) No, this isn't a thread about deficits or debt. At present, I don't think those pose the biggest challenge to us, or even probably one of the top five.

8) Rather, this is about a deadly disease that hit DC & the patient refused to take any medicine for it.

9) The disease was the failure to address the major problems of the day, whether it was deficits, Islamic terrorism, the banking crisis, or trade.

10) Vote fraud & this frankenstein of an election is only the latest SYMPTOM of this much larger disease.
POLITICS , GOVERNMENT
Yet Another Columnist
Yet Another Columnist
@Sime0nStylites
Typically excellent piece from @dsquareddigest The exponential insight is especially neat. Think of it a little like fishing...today you can’t export oysters to the EU (because you simply aren’t allowed to), tomorrow you don’t have a fish exporting business (to the EU).


The extremely small minority of people who known anything about this who think that Brexit will be good for the City make a number of arguments which I shall address in turn...

1. They need us more than we need them. This is a variant of the German carmakers argument. And we know how that went...Business will follow the profit opportunity and if that has moved then so will the business...

And what do we mean by us / we. We’re not talking about massed ranks of Euro investing / trading etc blue blooded British institutions.

Au contraire. We’re talking about the London based subs of US, Asian and indeed European capital markets players...As soon as they think the profit opportunity has moved then so will they...it’s a market innit...
GOVERNMENT
Mafevema #CommonGround
Mafevema #CommonGround
@mafevema
Why is Johnson's speech at the Munich conference hailed in some quarters, even by some journalists that should know better, as "a major policy speech" with "substance"? I went to read it expecting for once to be pleasantly surprised. Alas! Thread

It is full of the usual misplaced optimism not backed by any serious analysis, jingoism & digs at other EU leaders with transparent, nearly servile efforts to regain favour with the new US administration. A few examples:

The speech starts with the trademark rethorical device beloved of the UK right (whether to attack "woke' culture or pro-EU sentiments): A wildly exaggerated overblown simplistic statement that you then go on to "disprove"


So a dig aimed at Macron for saying NATO needs to adapt to changing circumstances and flattery towards America : "As you’ve seen and heard earlier, America is unreservedly back as leader of the free world and that is a fantastic thing."

Then the self- agrandissements : notice all the "I" & "Global Britain"
GOVERNMENT

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Vibhu Vashisth
Vibhu Vashisth
@VIBHU_Tweet
Rani Chennamma of Kittur was one of the first women rulers of India who fought against the might of the British Empire in 1824. Rani Chennamma was born in 1778 in a small village of Kakati in Belgaon distt of the State of Karnataka.


She was born into the Lingayat Community to a man named Dhulappa Desai. From a very young age she was trained in horse riding,sword fighting, archery and diplomacy. At a very young age of 15 yrs, she was married to the King of Kittur and became the Queen of Kittur.


It is said that King of Kittur Mallasarja was once moving around in the neighbouring kingdoms to find support to fight Tipu Sultan. It is then, when he came across Chennamma and he immediately got attracted to her sheer confidence and bravery.

Rani Chennamma and King Mallasarja had a son together who died very soon after the death of King Mallasarja in 1816. As the Queen of Kittur, Rani Chennamma immediately adopted Shivalingappa as her son and declared him the heir to the throne of Kittur.

This did not go well with the British East India Company who was enforcing the Doctrine of Lapse those days, according to which the adopted children of the Indian rulers were not allowed to become their heirs and if the native rulers did not have children of their own, their...
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Conviction | Patience
Conviction | Patience
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H was always unseen in S2NL :)

Those who exited at 1500 needed money. They can always come back near 969. Those who exited at 230 also needed money. They can come back near 95.

Those who sold L @ 660 can always come back at 360. Those who sold S last week can be back @ 301
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Jaya_Upadhyaya
Jaya_Upadhyaya
@Jayalko1
NARHARI AND BHAGWAN PANDURANG/VITTHAL

Once a goldsmith by the name of Narhari lived in Pandharpur. He excelled in his craft. He had vowed not to look at Pandurang or visit his mandir ever, as he was a Shiva Bhakt.
One day, a wealthy merchant visited him.


He wanted a gold girdle studded with precious gems, to be made for Prabhu Vitthal. Narhari refused to make it as it was for Vitthal.
After many requests, he agreed to make the girdle but asked the merchant to bring the measurement from the mandir as he himself would not go there


The measurement was given n he made the girdle. When the girdle was put on Vitthal, it was loose. Narhari had to shorten it. Now the girdle became tight. So Narhari was forced to take measurement on his own. He had to go to the mandir but went blindfolded to avoid seeing Vitthal


In the Mandir, when blindfolded Narhari touched Vitthal, he felt as if he was touching Shiva with matted hair, the moon, snake in His neck and Trishul in His hand. Ecstatic with joy, he removed the blindfold to see Shiva but he found the murti of Vitthal with Rukmini there.


He realised the truth that there was no difference between Vitthal and Shiva. Narhari at once fell at the feet of Panduranga. He then took the measurement of the waist of Vitthal and this time the ornament fit the Murti perfectly.

Narayan Hari🙏🏻
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Robin Berjon
Robin Berjon
@robinberjon
Recently, the @CNIL issued a decision regarding the GDPR compliance of an unknown French adtech company named "Vectaury". It may seem like small fry, but the decision has potential wide-ranging impacts for Google, the IAB framework, and today's adtech. It's thread time! 👇

It's all in French, but if you're up for it you can read:
• Their blog post (lacks the most interesting details): https://t.co/PHkDcOT1hy
• Their high-level legal decision: https://t.co/hwpiEvjodt
• The full notification: https://t.co/QQB7rfynha

I've read it so you needn't!

Vectaury was collecting geolocation data in order to create profiles (eg. people who often go to this or that type of shop) so as to power ad targeting. They operate through embedded SDKs and ad bidding, making them invisible to users.

The @CNIL notes that profiling based off of geolocation presents particular risks since it reveals people's movements and habits. As risky, the processing requires consent — this will be the heart of their assessment.

Interesting point: they justify the decision in part because of how many people COULD be targeted in this way (rather than how many have — though they note that too). Because it's on a phone, and many have phones, it is considered large-scale processing no matter what.
TECH