Starting PhD student pro tips:
- Keep a backlog of “small ideas” that you don’t find the time to work on. Soon enough you will be asked to supervise undergrad students in some capacity, and these ideas will be exactly what they need to get started.
(read: if people consistently don’t buy your idea, consider that they may be correct)
(but probably submit anyway - better to aim high and fail than to aim low)
(P.S.: still working on this one myself - I may get there in retirement)
More from Education
Time for some thoughts on schools given the revised SickKids document and the fact that ON decided to leave most schools closed. ON is not the only jurisdiction to do so, but important to note that many jurisdictions would not have done so -even with higher incidence rates.
As outlined in the tweet by @NishaOttawa yesterday, the situation is complex, and not a simple right or wrong https://t.co/DO0v3j9wzr. And no one needs to list all the potential risks and downsides of prolonged school closures.
On the other hand: while school closures do not directly protect our most vulnerable in long-term care at all, one cannot deny that any factor potentially increasing community transmission may have an indirect effect on the risk to these institutions, and on healthcare.
The question is: to what extend do schools contribute to transmission, and how to balance this against the risk of prolonged school closures. The leaked data from yesterday shows a mixed picture -schools are neither unicorns (ie COVID free) nor infernos.
Assuming this data is largely correct -while waiting for an official publication of the data, it shows first and foremost the known high case numbers at Thorncliff, while other schools had been doing very well -are safe- reiterating the impact of socioeconomics on the COVID risk.
A group of Ontario experts led by SickKids has updated its guidance for school operation during the COVID-19 pandemic. The living document, COVID-19: Updated Guidance for School Operation During the Pandemic, can be read here: https://t.co/rotLqDqkQh pic.twitter.com/q7kVezAPoG
— SickKids_TheHospital (@SickKidsNews) January 21, 2021
As outlined in the tweet by @NishaOttawa yesterday, the situation is complex, and not a simple right or wrong https://t.co/DO0v3j9wzr. And no one needs to list all the potential risks and downsides of prolonged school closures.
1/It's the eve of provincial announcements on schools reopening for in-person instruction.
— Nisha Thampi (@NishaOttawa) January 20, 2021
Households are under stress and experts are divided on whether schools are unicorns or infernos.
Everyone wants to do right by kids, who have borne so much throughout this pandemic.
On the other hand: while school closures do not directly protect our most vulnerable in long-term care at all, one cannot deny that any factor potentially increasing community transmission may have an indirect effect on the risk to these institutions, and on healthcare.
The question is: to what extend do schools contribute to transmission, and how to balance this against the risk of prolonged school closures. The leaked data from yesterday shows a mixed picture -schools are neither unicorns (ie COVID free) nor infernos.
Assuming this data is largely correct -while waiting for an official publication of the data, it shows first and foremost the known high case numbers at Thorncliff, while other schools had been doing very well -are safe- reiterating the impact of socioeconomics on the COVID risk.
Our preprint on the impact of reopening schools on reproduction number in England is now available online: https://t.co/CpfUGzAJ2S. With @Jarvis_Stats @amyg225 @kerrylmwong @KevinvZandvoort @sbfnk + John Edmunds. NOT YET PEER REVIEWED. 1/
We used contact survey data collected by CoMix (https://t.co/ezbCIOgRa1) to quantify differences in contact patterns during November (Schools open) and January (Schools closed) 'Lockdown periods'. NOT YET PEER REVIEWED 2/
We combined this analysis with estimates of susceptibility and infectiousness of children relative to adults from literature. We also inferred relative susceptibility by fitting R estimates from CoMix to EpiForecasts estimates(https://t.co/6lUM2wK0bn). NOT YET PEER REVIEWED 3/
We estimated that reopening all schools would increase R by between 20% to 90% whereas reopening primary or secondary schools alone would increase R by 10% to 40%, depending on the infectiousness/susceptibility profile we used. NOT YET PEER REVIEWED 4/
Assuming a current R of 0.8 (in line with Govt. estimates: https://t.co/ZZhCe79zC4). Reopening all schools would increase R to between 1.0 and 1.5 and reopening either primary or secondary schools would increase R to between 0.9 and 1.2. NOT YET PEER REVIEWED 5/

We used contact survey data collected by CoMix (https://t.co/ezbCIOgRa1) to quantify differences in contact patterns during November (Schools open) and January (Schools closed) 'Lockdown periods'. NOT YET PEER REVIEWED 2/
We combined this analysis with estimates of susceptibility and infectiousness of children relative to adults from literature. We also inferred relative susceptibility by fitting R estimates from CoMix to EpiForecasts estimates(https://t.co/6lUM2wK0bn). NOT YET PEER REVIEWED 3/

We estimated that reopening all schools would increase R by between 20% to 90% whereas reopening primary or secondary schools alone would increase R by 10% to 40%, depending on the infectiousness/susceptibility profile we used. NOT YET PEER REVIEWED 4/

Assuming a current R of 0.8 (in line with Govt. estimates: https://t.co/ZZhCe79zC4). Reopening all schools would increase R to between 1.0 and 1.5 and reopening either primary or secondary schools would increase R to between 0.9 and 1.2. NOT YET PEER REVIEWED 5/

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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK

In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa

Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
