Webinar on tools for assessing national #climate pledges (NDCs) by @WRIClimate. @davidwaskow reminds: #ParisAgreement is meant to work thru an iterative process of increasing ambition (faster emission reductions), leading to #netzero emissions by 2050. (Thread 1/n)
2 are on track (e.g., crop yields)
13 right direction but too slow (e.g., need electric vehicle sales to be 22x faster than now)
2 in wrong direction: forests, ag emissions
@davidwaskow from @climateactiontr, @WRIClimate et al 3/n
100s of credible datasets,
100,000s of data points
to assess #climate trends, targets, bring transparency to inform + drive #ClimateAction.
For govts, biz, researchers, NGOs
Run by @JohannesFried.
(See also other forest, energy, ... tools) 5/n
Only 20 countries have long-term #climate strategies
Only 20 have submitted updated, more ambitious pledges (NDCs)
26 have net zero targets
62 have economy wide #climate policy
@MengpinGe (7/n)
Coming soon: #NetZero tracker (see report:https://t.co/Kb5JB2VgMu).
@MengpinGe (9/n)
OECD 2018 found $78.9 bn/yr (78% public $), of $100 bn/yr promised in Paris, per @davidwaskow (12/12)
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Keep dwelling on this:
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs
Further Examination of the Motif near PRRA Reveals Close Structural Similarity to the SEB Superantigen as well as Sequence Similarities to Neurotoxins and a Viral SAg.
The insertion PRRA together with 7 sequentially preceding residues & succeeding R685 (conserved in β-CoVs) form a motif, Y674QTQTNSPRRAR685, homologous to those of neurotoxins from Ophiophagus (cobra) and Bungarus genera, as well as neurotoxin-like regions from three RABV strains
(20) (Fig. 2D). We further noticed that the same segment bears close similarity to the HIV-1 glycoprotein gp120 SAg motif F164 to V174.
https://t.co/EwwJOSa8RK
In (B), the segment S680PPRAR685 including the PRRA insert and highly conserved cleavage site *R685* is shown in van der Waals representation (black labels) and nearby CDR residues of the TCRVβ domain are labeled in blue/white
https://t.co/BsY8BAIzDa
Sequence Identity %
https://t.co/BsY8BAIzDa
Y674 - QTQTNSPRRA - R685
Similar to neurotoxins from Ophiophagus (cobra) & Bungarus genera & neurotoxin-like regions from three RABV strains
T678 - NSPRRA- R685
Superantigenic core, consistently aligned against bacterial or viral SAgs