1/ Today @Cruise announced over $2 billion of new funding from Microsoft, GM, Honda, and some great institutional investors.

The vanity metric: $30 billion post-money valuation
The real metric: 0 million customers

Wait… what?

2/ Food. Energy. Real Estate. Transportation. The handful of true multi-trillion dollar markets and the building blocks of human life. Substantial change here requires - at minimum - the proverbial “10x better” product. That is a hard thing to build.
3/ Cars are driven by humans. Humans improved safety by ~2x in ~50x years. We suck. Robots are likely to improve this by 100x or more in 3-5 years. That is a big deal. Car accidents are the #1 killer of teenagers in the US, a very uncomfortable fact.
4/ But safety ain’t enough (sadly). Self-driving cars also give you *time* back, one of the most precious resources. They’ll also cost less than using rideshare, which is still priced as a luxury. And soon much less than owning a car. Ours also feel like riding in a spaceship.
5/ AVs will be a major lifestyle upgrade for billions of people, and one that requires almost zero effort to unlock.
6/ Tech to do this is hard. It’s not just AI, but realtime, safety-critical AI. There's also manufacturing, industrializing new tech, and rollout of fleets. Few companies can acquire or already possess the critical mass of talent, capital, tech, and expertise to pull this off.
7/ Even fewer co’s will achieve escape velocity; most will end up being worth nothing. There will be little incentive to use any product that’s not one of the best.
8/ A handful of front-runner AV companies that look most likely to win are attracting substantially all of the best human capital and a huge chunk of the financial capital.
9/ That is how a company without millions of customers can be valued at $30 billion. We've made some incredible progress towards this vision, but there is much left to do. Back to work!

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https://t.co/6cRR2B3jBE
Viruses and other pathogens are often studied as stand-alone entities, despite that, in nature, they mostly live in multispecies associations called biofilms—both externally and within the host.

https://t.co/FBfXhUrH5d


Microorganisms in biofilms are enclosed by an extracellular matrix that confers protection and improves survival. Previous studies have shown that viruses can secondarily colonize preexisting biofilms, and viral biofilms have also been described.


...we raise the perspective that CoVs can persistently infect bats due to their association with biofilm structures. This phenomenon potentially provides an optimal environment for nonpathogenic & well-adapted viruses to interact with the host, as well as for viral recombination.


Biofilms can also enhance virion viability in extracellular environments, such as on fomites and in aquatic sediments, allowing viral persistence and dissemination.

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