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https://t.co/6cRR2B3jBE
Viruses and other pathogens are often studied as stand-alone entities, despite that, in nature, they mostly live in multispecies associations called biofilmsтАФboth externally and within the host.
https://t.co/FBfXhUrH5d
Microorganisms in biofilms are enclosed by an extracellular matrix that confers protection and improves survival. Previous studies have shown that viruses can secondarily colonize preexisting biofilms, and viral biofilms have also been described.
...we raise the perspective that CoVs can persistently infect bats due to their association with biofilm structures. This phenomenon potentially provides an optimal environment for nonpathogenic & well-adapted viruses to interact with the host, as well as for viral recombination.
Biofilms can also enhance virion viability in extracellular environments, such as on fomites and in aquatic sediments, allowing viral persistence and dissemination.
Viruses and other pathogens are often studied as stand-alone entities, despite that, in nature, they mostly live in multispecies associations called biofilmsтАФboth externally and within the host.
https://t.co/FBfXhUrH5d
Microorganisms in biofilms are enclosed by an extracellular matrix that confers protection and improves survival. Previous studies have shown that viruses can secondarily colonize preexisting biofilms, and viral biofilms have also been described.
...we raise the perspective that CoVs can persistently infect bats due to their association with biofilm structures. This phenomenon potentially provides an optimal environment for nonpathogenic & well-adapted viruses to interact with the host, as well as for viral recombination.
Biofilms can also enhance virion viability in extracellular environments, such as on fomites and in aquatic sediments, allowing viral persistence and dissemination.
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Week 1 highlights: getting shortlisted for YC W2019ЁЯдЮ, acquiring a premium domainЁЯТ░, meeting Substack's @hamishmckenzie and Stripe CEO @patrickc ЁЯдй
2/ So what is Brew?
brew / bru : / to make (beer, coffee etc.) / verb: begin to develop ЁЯМ▒
A place for you to enjoy premium content while supporting your favorite creators. Sort of like a тАШConsumer-facing PatreonтАЩ cc @jackconte
(weтАЩre still working on the pitch)
3/ So, why be so transparent? Two words: launch strategy.
jk ЁЯШЕ a) I loooove doing something consistently for a long period of time b) limited downside and infinite upside (feedback, accountability, reach).
cc @altimor, @pmarca
4/ https://t.co/GOQJ7LjQ2t domain ЁЯН╗
It started with a cold email. Guess what? He was using BuyMeACoffee on his blog, and was excited to hear about what we're building next. Within 2w, we signed the deal at @Escrowcom's SF office. YouтАЩre a pleasure to work with @MichaelCyger!
5/ @ycombinator's invite for the in-person interview arrived that evening. Quite a day!
Thanks @patio11 for the thoughtful feedback on our YC application, and @gabhubert for your directions on positioning the product тАФ set the tone for our pitch!
Week 1 highlights: getting shortlisted for YC W2019ЁЯдЮ, acquiring a premium domainЁЯТ░, meeting Substack's @hamishmckenzie and Stripe CEO @patrickc ЁЯдй
2/ So what is Brew?
brew / bru : / to make (beer, coffee etc.) / verb: begin to develop ЁЯМ▒
A place for you to enjoy premium content while supporting your favorite creators. Sort of like a тАШConsumer-facing PatreonтАЩ cc @jackconte
(weтАЩre still working on the pitch)
3/ So, why be so transparent? Two words: launch strategy.
jk ЁЯШЕ a) I loooove doing something consistently for a long period of time b) limited downside and infinite upside (feedback, accountability, reach).
cc @altimor, @pmarca
4/ https://t.co/GOQJ7LjQ2t domain ЁЯН╗
It started with a cold email. Guess what? He was using BuyMeACoffee on his blog, and was excited to hear about what we're building next. Within 2w, we signed the deal at @Escrowcom's SF office. YouтАЩre a pleasure to work with @MichaelCyger!
5/ @ycombinator's invite for the in-person interview arrived that evening. Quite a day!
Thanks @patio11 for the thoughtful feedback on our YC application, and @gabhubert for your directions on positioning the product тАФ set the tone for our pitch!