https://t.co/NEf9HK6ReB
"ONLY place where this thing could emerge, naturally or Artificially, is by passage in HUMANIZED MICE"
1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!
2 papers:
Human–viral molecular mimicry
https://t.co/irfH0Zgrve
Molecular Mimicry
https://t.co/yLQoUtfS6s
https://t.co/NEf9HK6ReB
"ONLY place where this thing could emerge, naturally or Artificially, is by passage in HUMANIZED MICE"
The PEPTIDES again!
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) October 21, 2020
"Such a peptide commonality is unexpected and highly improbable from a mathematical point of view"
Molecular mimicry between SARS-CoV-2 spike glycoprotein and mammalian proteomes: implications for the vaccinehttps://t.co/yLQoUtxtv2
via @gerdosi https://t.co/lsCv2j4gf9 pic.twitter.com/hdgM5KZd39
"Such a peptide commonality is unexpected and highly improbable from a mathematical point of view"
https://t.co/NEf9HK6ReB
@flavinkins
Check every link, take your time.
Biovacc-19: A Candidate Vaccine for SARS-CoV-2 Developed from Analysis of its General Method of Action for Infectivity
https://t.co/lwnZSnmyVA
Image: Nonhuman-like (NHL) sequences found in SARS-CoV-2 spike protein S1.
Benchmarking evolutionary tinkering underlying human–viral molecular mimicry shows multiple host pulmonary–arterial peptides mimicked by SARS-CoV-2
https://t.co/irfH0Zgrve
Human Immune System Mice for Study of HIV-1 Infection of CNS
https://t.co/QwrCbNtUBc
"Immunodeficient mice transplanted with human cell populations or tissues, also known as human immune system mice, have become important & versatile tools for in vivo study"
https://t.co/MjVKVb7MTx
confirmation of peptide findings + autoimmune factors
showing different kinds of transgenic mouse experiments
@RandFanshier asks:
"was it given human umbilical cord stem cells as an embryo, or did it get human epithelial tissue implanted as a SCID mouse?
once when it is picked up!
once when it is dipped in sauce.!
once when it is eaten..!
https://t.co/6hQREvU6RG
@BBCWorld @CNN @shujamtaro @SolomonYue @HawleyMO @BorisJohnson @lukedepulford @DanGarrett97 @SenRickScott @swsjoerdsma @aaronMCN @tommycheungsy I can't believe these pictures. In this civilized society, we eat newborn mouse Scared me intolerable. #chinazi #WuhanCoronavirus \U0001f92e\U0001f92e pic.twitter.com/89Gc3fJafP
— Aura\u4e9e\u6a02 (@sauwingso) January 22, 2020
newly born mice (still hairless and barely able to open their eyes). It is typically served with some type of cold soy based sauce. The first squeak is when the mouse/rat is picked up with the chopsticks.
https://t.co/jPE10AK32N
Newborn mice (San Zhi Er) are eaten alive with chopsticks & served in a spicy sauce.
They are called “3 squeaks babies” because they scream 3 times.
Chinese Baike Baidu scrubbed the page
https://t.co/3IiIHOqtBp
Google Search shows it "item/三叫菜/3857789"
1. https://t.co/0XPEMIN5Oo (https://t.co/xs9pDkG2kE)
2. https://t.co/I2DbfJUChq (https://t.co/X7tR3Md491)
3. so-called dark dish "San Zhier". Is this dish really available? Or is it just a rumor?
https://t.co/OtXZOujPnd (https://t.co/0XPMxdLfmU)
https://t.co/7qbmZ02Ojc
and
https://t.co/oL8oUqQPqv
and
https://t.co/lfnCiDl5V5
and
https://t.co/68vEE8GYw8
Dr. Anony Mouse kindly provides some useful insights:
"Perhaps a glance at the ACE2 transgenic mouse paper would be nice:
https://t.co/VSSciCGeAl
Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2
Paper submitted for publication on March 12th
At the time of these experiments, a viral pandemic was raging in Wuhan during the 2 months from “discovery” of virus to this publication & all interactions with the outside world were completely closed off
The HfH-ACE2 transgenic mouse was developed in this paper in 2016 from the Baric lab, which people have pointed to back in May, when questions started to arise about what was going on. https://t.co/YuhcLfTBLZ. SARS-like WIV1-CoV poised for human emergence
Remember, no reference to the Mojang miners was made in this 2016 paper.
Looking at the Methods section of the 2020 transgenic ACE2 mouse paper, it states that this mouse was from “Ralph S Baric lab.”
This mouse had to have been at the WIV prior to the pandemic, since everything in Wuhan was closed from January to March. Also, how did any research get done at the WIV at that time, during total lockdown?
Those of us who do science for a living understand the sheer implausibility of performing these experiments, writing them up, and submitting for publication in a 7-8 week period from viral isolation to publication.
Especially during a viral pandemic where the entire city was completely shut down and movement restricted.
Possible? Yes. Probable?
I’ll leave that determination to the scientific community...
So what was really going on?
What likely happened is that they took the ACE2 transgenic mouse from the Baric lab and gave it a human immune system. This could be done by crossing the ACE2 transgenic mice with a mouse model (rag-/rag-) without a functioning immune system.
These animal crosses are all the rage in immunology.
By crossing various “knock out” and “knock in” mice, you get all sorts of interesting immune things to study.
It’s big in cancer immunology right now.
What the researchers at WIV didn’t plan for, I guess, is that SARS-CoV Urbani MA15 mouse adapted viral strain they were using continued to mutate in the animal model during passage.....
Even in the ACE2 transgenic experiments in the 2020 Cell paper, two mutations were found in S and nsp13 that led to brain tropism and death in a few of the mice, even with only one passage.
https://t.co/w4hhjzqW6K
Serial passaging in the chimeric mice selected for an even better human adapted strain.
This became more & more important to the scientists, since the better human adapted the strain became, the more like a real human infection it became in the mice.
I am sure the “dual use” potential of this sort of experiment did not escape the notice of the CCP, though it would have been true insanity to develop it in that direction.
But then again, they did very similar experiments in a Peking military laboratory back in September, where they developed the infamous N501 mutation (6 passages in mice)
Similar to one currently plaguing GB
https://t.co/su4MYQpM9I
&
https://t.co/I90OOCJg7o
Thailand medical news sticking the boot in again & raising suspicions about Chinese military research in above tweet which mutated Asn501 to Tyr (N501Y), within the RBD of the spike protein. https://t.co/I90OOCJg7o
— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) December 16, 2020
to make it deadlier for mice..and Brits?https://t.co/Or6aCkzKlP pic.twitter.com/XkurR21l4c
"Like Icarus flying too close to the sun, they could not stop themselves"
The researchers and the mice ;)
It was only lethal in this very inbred, manipulated mouse strain. At least theoretically. Though a virus with human potential for transmission was being used (mouse adapted SARS Urbani) the possibilities were endless.
The best laid plans of transgenic mice and men...
They could develop drugs to blunt the immune response. They could develop anti-virals.
They could design recombinant live attenuated coronavirus vaccines and rapidly test them in these mice.
The end of coronavirus as a threat to humans was at hand, if the experiments could just be performed correctly.
It’s exactly what some of us would have done
They likely said screw the GOF ethics
The experiments were just too cool, the potential benefit to humanity too great, and the ego boost from the possible accolades too strong.
We scientists totally get it.
But we all know what happened to Icarus, don't we?
There is old Baric looking on in horror as his dear Chinese Icarus plunges......... to our death!
These are the experiments I think they were doing in Wuhan during the past 18-24 months when the darn thing escaped.
Who knows what happened?
I suspect a lab tech handling an infected mouse was infected despite all the precautions.
Maybe animal waste wasn’t handled properly.
(Billy suspects they sold the lab mice)
A human adapted SARS strain, with wider tissue tropism, better ACE2 binding & better ability to shut off interferon production than SARS was produced, and it LEAKED..
Of course this tragic mice story ties in well with DRASTIC research into "vaccines gone wrong" posted a while back on Twitter by @Rossana38510044
https://t.co/sY7A17nASd
1/ Was the pandemic caused by SARS2 the result of vaccine research gone wrong? The following thread is the product of a DRASTIC* investigation: the possibility that SARS2 and RaTG13 might be two different vaccine strategies and that SARS2 leaked from a lab during its development.
— Rossana Segreto (@Rossana38510044) October 3, 2020
More from Billy Bostickson 🏴👁&👁 🆓
1. Thread: RaTG13 Real or Fake?
A Norwegian Scientist @Vehuardo recently claimed RaTG13 is an "authentic virus"
https://t.co/tAXMNTwdhA
This failed to take into account the work of our DRASTIC colleagues & other published analyses.
This thread is a polite attempt to educate.
2. https://t.co/tw606vgHwp
which says RaTG13 doesn't make sense on how it was sequenced, or how the data got so messed up in the lab as to include copy paste mistakes, bat dna, pangolin dna, rice dna, mice dna, & nobody should use it to form conclusions until it's properly vetted
2 (cont)
"sequence is incomplete & provided segment doesn't function. The identified markers suggest partial match basis & actual virus itself as described by the sequence can't functionally exist due to incoherent structures that appear to be the result of sample contamination"
3. RaTG13 integrity is further attacked here:
The Validity of critical pieces of evidence for the natural origin of SARS-CoV-2 is Dubious, and needed to be
4. and here:
Major Concerns on the Identification of Bat Coronavirus Strain RaTG13 and Quality of Related Nature
A Norwegian Scientist @Vehuardo recently claimed RaTG13 is an "authentic virus"
https://t.co/tAXMNTwdhA
This failed to take into account the work of our DRASTIC colleagues & other published analyses.
This thread is a polite attempt to educate.
2. https://t.co/tw606vgHwp
which says RaTG13 doesn't make sense on how it was sequenced, or how the data got so messed up in the lab as to include copy paste mistakes, bat dna, pangolin dna, rice dna, mice dna, & nobody should use it to form conclusions until it's properly vetted
2 (cont)
"sequence is incomplete & provided segment doesn't function. The identified markers suggest partial match basis & actual virus itself as described by the sequence can't functionally exist due to incoherent structures that appear to be the result of sample contamination"
3. RaTG13 integrity is further attacked here:
The Validity of critical pieces of evidence for the natural origin of SARS-CoV-2 is Dubious, and needed to be
4. and here:
Major Concerns on the Identification of Bat Coronavirus Strain RaTG13 and Quality of Related Nature
PCR Drosten Fail Compilation
1. Ten Fatal Errors: Scientists Attack Paper That Established Global PCR Driven Lockdown
https://t.co/25p88F2xu6
2. Review report Corman-Drosten et al.
https://t.co/8rlT4MWoyI
3. Consequences of false
PCR Drosten Fail Compilation
4. Files for download
https://t.co/SqDrZjB9em
5. Addendum
https://t.co/IygCWvnAsP
6. False positives in reverse transcription PCR testing for SARS-CoV-2
https://t.co/HxpSZkzZ7Q
7. Discussion on Retraction
PCR Drosten Fail Compilation
8. 124 Tweet Thread by Bobby Rajesh Malhotra
@Bobby_Network
https://t.co/cdot5yIeuf
9. Another shorter thread by @Bobby_Network
https://t.co/kqFW9GsSeD
10. Thread by Abir Ballan
PCR Drosten Fail Compilation
11. Mini Thread by @Kevin_McKernan
https://t.co/pntydnd80L
12. Another longer thread by @Kevin_McKernan
https://t.co/5hBYIlXFnQ
13.
1. Ten Fatal Errors: Scientists Attack Paper That Established Global PCR Driven Lockdown
https://t.co/25p88F2xu6
2. Review report Corman-Drosten et al.
https://t.co/8rlT4MWoyI
3. Consequences of false
PCR Drosten Fail Compilation
4. Files for download
https://t.co/SqDrZjB9em
5. Addendum
https://t.co/IygCWvnAsP
6. False positives in reverse transcription PCR testing for SARS-CoV-2
https://t.co/HxpSZkzZ7Q
7. Discussion on Retraction
PCR Drosten Fail Compilation
8. 124 Tweet Thread by Bobby Rajesh Malhotra
@Bobby_Network
https://t.co/cdot5yIeuf
9. Another shorter thread by @Bobby_Network
https://t.co/kqFW9GsSeD
10. Thread by Abir Ballan
PCR Drosten Fail Compilation
11. Mini Thread by @Kevin_McKernan
https://t.co/pntydnd80L
12. Another longer thread by @Kevin_McKernan
https://t.co/5hBYIlXFnQ
13.
Tactics & Direct Action are necessary against Tyrants
"Guerrilla tactics used against the military include assassinations of its officials, bombing military property and sabotaging infrastructure such as telecom towers and
Dr Sasa, spokesperson for the exiled opposition National Unity Government (NUG), said the public had no choice but to defend itself:
"The military are not only destroying our democracy and freedom, but they are destroying every day our dignity as human beings"
It’s do or die”
The residence of coup leader Min Aung Hlaing is a testament to his ambition—and his fear of the people he seeks to rule
https://t.co/yInq583gI5
Apart from Mansion 1, which serves as his official residence, Min Aung Hlaing is known to have several other homes. One is the Yarzathingaha residence in Naypyitaw’s Ottarathiri Township & another is at No.14 Inya Road in Yangon, also properties in Pyin Oo Lwin.
As Myanmar’s most powerful family accumulates vast wealth through military-linked companies like Mytel, the country’s poverty rate will double by next year due to the combined impact of Covid-19 pandemic & the coup.
Nearly half of Myanmar will be living in absolute poverty
"Guerrilla tactics used against the military include assassinations of its officials, bombing military property and sabotaging infrastructure such as telecom towers and
Dr Sasa, spokesperson for the exiled opposition National Unity Government (NUG), said the public had no choice but to defend itself:
"The military are not only destroying our democracy and freedom, but they are destroying every day our dignity as human beings"
It’s do or die”
The residence of coup leader Min Aung Hlaing is a testament to his ambition—and his fear of the people he seeks to rule
https://t.co/yInq583gI5
Apart from Mansion 1, which serves as his official residence, Min Aung Hlaing is known to have several other homes. One is the Yarzathingaha residence in Naypyitaw’s Ottarathiri Township & another is at No.14 Inya Road in Yangon, also properties in Pyin Oo Lwin.
As Myanmar’s most powerful family accumulates vast wealth through military-linked companies like Mytel, the country’s poverty rate will double by next year due to the combined impact of Covid-19 pandemic & the coup.
Nearly half of Myanmar will be living in absolute poverty
