Wiley buys Hindawi -- a $298 million acquisition for GBP 25 million in annual APC revenues -- in bid to expand open-access platforms @pbasken
Does publishing platform Phenom get rolled into Atypon at some stage? > \u201cThe US-based academic publisher Wiley has agreed to acquire London-based Hindawi in what it described as a push to improve its delivery of open-access options.\u201d https://t.co/J3TQpgu809 pic.twitter.com/ZoLydLjMYj— lorcan dempsey (@lorcanD) January 5, 2021
This is a perfect example of the "ecosystem shrink" that I'm concerned about during and post-Plan S. Obvs there are loads of business reasons beyond eliminating another pure-OA stand-alone publisher but the risk remains: How many will there be in 2 years? #AnotherOneBitesTheDust https://t.co/DaLpe3AY8F— Sara Rouhi (@RouhiRoo) January 5, 2021
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As a foster parent I have a few words about the experience.
Content and trigger warning, there will be talk of severe child abuse.
First, I want to talk about motivation for fostering.
Different people are motivated differently, so I can only speak for my family.
We originally wanted to adopt children because we can't have our own.
While researching adoption, we learned about fostering.
We felt we had room in our lives to take in kids who needed a place to go. So we shifted our focus.
Since then we have had several children come and go. Each situation was different, and I will get to that.
Regarding the "salary" we get: there is no salary.
We do receive money to cover some of the costs we incur, like paying for medical care, buying them clothes, etc.
It is not anywhere near the quoted $39K.
All told, we generally end up going out of pocket to cover all expenses.
We take kids under 3, and as any parent can tell you, diapers, clothes, food, formula, various medical costs... It all adds up really fast.
Here’s what "financial wellness" means to me
Humans are programmed to think short-term
Evolutionary, thinking short-term makes sense. It helps with survival.
Financial wellness is all about training yourself to develop a long-term mindset
Not easy -- it takes practice
If you join the right tribes, you can’t help but improve
Twitter / Podcasts / Blogs / YouTube -- when used correctly -- are amazing
1/ YouTube is an AMAZING resource when used properly (Thread)— Brian Feroldi (@BrianFeroldi) November 7, 2020
Here are my favorite YouTube channels:
Mark Rober - @MarkRober
Smarter Every Day - @smartereveryday
Stuff Made Here - @stuffmadehere
Wintegartan - @wintergatan
Educate yourself - constantly!
These 3 categories have an outsized influence on all areas of your life
1/ Book recommendations (thread)— Brian Feroldi (@BrianFeroldi) November 20, 2020
Richest Man in Babylon
Millionaire Next Door
Rich Dad, Poor Dad
The Wealthy Barber
In the beginning, focus on growing your income
Do more than what is expected
Become a lynchpin
Find a career that you ENJOY (<- important!) that also has high-income potential
Start a side hustle (<- important!)
Build your talent
What is it & the difference between the 2.
Tax evasion = Illegal 🚫 Criminal
Tax avoidance = legal ✅ allowed
Tax evasion is an illegal & unlawful practice of not paying tax. A person or business structures their affairs in a way that they don't pay taxes due to SARS. This happens by not reporting their income, deducting frivolous expenses, inflating expenses, underpaying or understating
Tax avoidance on the other hand is a legal & allowed way of minimizing your tax liability. Our tax legislations allow us to structure our affairs in order to minimize your tax liability
E.g. in personal taxes, medical aid, out of pocket, RA deductions, TFSA etc. In VAT, output & input tax provisions allows for payment of lesser taxes. Business are also allowed to deduct allowable expenses, ring fence losses etc in order to minimize their tax liability
Q3fy21/20 in crs
Rev 1288/730 ,up 76%
PAT 273/73 ,up 274%
Generic API growth 103% yoy
ARVs up 175% yoy
Generic FDF up 47%
Custom synthesis up 63% yoy
Onco API growth 36%
Commercialized 60+ products
61 DMFs filed
Filed 26 ANDAs with USFDA
9 final & 8 tentative approvals
Filed 12 dossiers in Canada, 9 in EU ,8 with WHO,2 in https://t.co/Q35cgK2hvy, 2 in India
CDMO services for Global pharma
Speciality ingredients in Nutraceuticals,dietary,cosmetics
Commercial scale mfg,clinical phase supplies,Analytics & research
API validation plannd in Unit 5
LSPL-API validatn planned
Revenue breakup in crs
Generic API 731/360
Generic FDF 430/292
Generic FDF 430/292
Entered in longterm partnership with leading generic player in EU for contract mfg
Synthesis CDMO 127/78 crs
Revenue from custom synthesis, strong growth 63% yoy
Total active projects in CDMO stood at 49 in Q3
Partnered Large global pharma & mid ,small biotech companies
Commercial supplies ongoing for 4 products
1/ Official short interest is only posted twice per month. Daily estimates by data firms (e.g. S3 Partners) can be inaccurate, especially if there is high intraday volume and volatility
2/ De-grossing suggests that hedge funds facing existential loss likely to have already covered.
Short positions opened in last 3 days was ~35M shares all above $300 suggesting that the cost basis has been reset. The original shorters have likely covered already.
3/ There is a staggering 1.38m put options open vs. 233k call options. This 1.15m net put exposure means that MM likely owning ~11m shares short for delta hedging. These shares are unlikely to be squeezed
4/ Short squeeze and gamma squeeze likely to have already occurred. Continued share price increases likely driven by new investors joining WSB/RH. Buying of GME has now expanded beyond US to other countries.
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@NBA @StephenKissler @yhgrad 1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice
1. From Day 1, SARS-COV-2 was very well adapted to humans .....and transgenic hACE2 Mice— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 30, 2021
"we generated a mouse model expressing hACE2 by using CRISPR/Cas9 knockin technology. In comparison with wild-type C57BL/6 mice, both young & aged hACE2 mice sustained high viral loads... pic.twitter.com/j94XtSkscj
@NBA @StephenKissler @yhgrad 2. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2
1. High Probability of serial passaging in Transgenic Mice expressing hACE2 in genesis of SARS-COV-2!— Billy Bostickson \U0001f3f4\U0001f441&\U0001f441 \U0001f193 (@BillyBostickson) January 2, 2021
Human\u2013viral molecular mimicryhttps://t.co/irfH0Zgrve
Molecular Mimicryhttps://t.co/yLQoUtfS6s https://t.co/lsCv2iMEQz
@NBA @StephenKissler @yhgrad B.1.1.7 has an unusually large number of genetic changes, ... found to date in mouse-adapted SARS-CoV2 and is also seen in ferret infections.
@NBA @StephenKissler @yhgrad We adapted a clinical isolate of SARS-CoV-2 by serial passaging in the ... Thus, this mouse-adapted strain and associated challenge model should be ... (B) SARS-CoV-2 genomic RNA loads in mouse lung homogenates at P0 to P6.
"If only someone would tell me how I can get a startup to notice me."
"I guess it's impossible and I'll never break into the industry."
Courtesy of @edbrisson's wonderful thread on breaking into comics – https://t.co/TgNblNSCBj – here is why the same applies to Product Management, too.
"I really want to break into comics"— Ed Brisson (@edbrisson) December 4, 2018
"If only someone would tell me how I can get an editor to notice me."
"I guess it's impossible and I'll never break into the industry."
There is no better way of learning the craft of product, or proving your potential to employers, than just doing it.
You do not need anybody's permission. We don't have diplomas, nor doctorates. We can barely agree on a single standard of what a Product Manager is supposed to do.
But – there is at least one blindingly obvious industry consensus – a Product Manager makes Products.
And they don't need to be kept at the exact right temperature, given endless resource, or carefully protected in order to do this.
They find their own way.
The environment that Ousmane Dembélé grew up in and the environment that FC Barcelona seeks to engulf its youngsters with could not be more different.
The Great Gatsby starts with a life lesson.
"Whenever you feel like criticizing any one, just remember that all the people in this world haven't had the advantages that you've had."
Ousmane hasn’t had the advantages that La Masia youngsters have had. That’s why he’s Ousmane.
Like every La Masia youngster, Ousmane grew up with a dream: playing for Barça.
Like every youngster, he fought to stand out amid a talented group of players, the majority of which would fail to go pro.
However, his football education was the polar opposite to that of La Masia.
Ousmane did not reside in one of the most expensive academies in Europe: he lived in a low-cost public housing unit in Normandy. He did not play in the well-trimmed pitches of La Masia, he played in the concrete jungles of Évreux. These disadvantages made him the man he is today.
While street soccer encourages individuality & creative freedom, academy-based training like La Masia encourages unselfishness & teamwork.
That’s why Barça produce certain types of 20-year-olds like a factory line. It’s also why Barça spent €145m on a 20-year-old Ousmane.
People in a free society are entitled to any point of view no matter how obviously wrong or outlandish or destructive provided they do not impose their views on others.
But suggesting that something ignorant or divorced from reality warrants the same kind of treatment in public debate as something based in fact or at least credible is absurd and when done on behalf of a society in public media or academic settings it is self-destructive.
We would not grant media coverage or much bandwidth at all to a group that argued that unicorns exist or that there was a pot of gold at the end of the rainbow. Yet views like denying climate change or basing policy decisions on sweeping, obvious lies, are just as unsound.
Somewhere, somehow, judgments must be made. Some behaviors are wrong and must be condemned. Someone must challenge lies and demand facts. Coddling people who embrace idiocies does not help them no matter how loudly they demand to be coddled.
A long time ago, I was a talent agent. I worked for a woman named Susan Smith, who had her own small boutique agency. She was known for three things:
1. She had fantastic taste in clients. If there is someone you admire, odds are good that at some point, she was their agent,
2. She could negotiate a deal like few who have ever trod the earth. Casting would give her all the money they had budgeted for that part, plus a little more, plus promising to get her dog Barnaby groomed. She was magnificent to watch.
3. She was insane.
I'm sure you're thinking, "Quinn, it's the entertainment industry, they are all insane." Yes, many are. So consider this; if you told someone you worked for Susan, people who worked for insane people would look and you and whisper, "I hear she's insane."